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Items: 1 to 20 of 323

1.

In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo.

Hu X, Majchrzak K, Liu X, Wyatt MM, Spooner CJ, Moisan J, Zou W, Carter LL, Paulos CM.

Cancer Res. 2018 Jul 15;78(14):3888-3898. doi: 10.1158/0008-5472.CAN-17-3973. Epub 2018 May 16.

2.

A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development.

He Z, Ma J, Wang R, Zhang J, Huang Z, Wang F, Sen S, Rothenberg EV, Sun Z.

Nat Immunol. 2017 Oct;18(10):1128-1138. doi: 10.1038/ni.3832. Epub 2017 Aug 28.

3.

RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction.

Enomoto D, Matsumoto K, Yamashita T, Kobayashi A, Maeda M, Nakayama H, Obana M, Fujio Y.

PLoS One. 2017 Aug 21;12(8):e0183584. doi: 10.1371/journal.pone.0183584. eCollection 2017.

4.

RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.

Clin Exp Immunol. 2017 Apr;188(1):63-78. doi: 10.1111/cei.12905. Epub 2017 Jan 5.

5.

RORγt antagonist suppresses M3 muscarinic acetylcholine receptor-induced Sjögren's syndrome-like sialadenitis.

Tahara M, Tsuboi H, Segawa S, Asashima H, Iizuka-Koga M, Hirota T, Takahashi H, Kondo Y, Matsui M, Matsumoto I, Sumida T.

Clin Exp Immunol. 2017 Feb;187(2):213-224. doi: 10.1111/cei.12868. Epub 2016 Oct 11.

6.

Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium.

Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N.

PLoS One. 2016 Jan 19;11(1):e0147064. doi: 10.1371/journal.pone.0147064. eCollection 2016.

7.

Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.

Nadeem A, Al-Harbi NO, Al-Harbi MM, El-Sherbeeny AM, Ahmad SF, Siddiqui N, Ansari MA, Zoheir KM, Attia SM, Al-Hosaini KA, Al-Sharary SD.

Pharmacol Res. 2015 Sep;99:248-57. doi: 10.1016/j.phrs.2015.06.001. Epub 2015 Jul 3.

PMID:
26149470
8.

Involvement of RORγt-overexpressing T cells in the development of autoimmune arthritis in mice.

Kondo Y, Yao Z, Tahara M, Iizuka M, Yokosawa M, Kaneko S, Segawa S, Tsuboi H, Yoh K, Takahashi S, Matsumoto I, Sumida T.

Arthritis Res Ther. 2015 Apr 20;17:105. doi: 10.1186/s13075-015-0606-5.

9.

RORγt(+) hematopoietic cells are necessary for tumor cell proliferation during colitis-associated tumorigenesis in mice.

Martin M, Kesselring RK, Saidou B, Brunner SM, Schiechl G, Mouris VF, Wege AK, Rümmele P, Schlitt HJ, Geissler EK, Fichtner-Feigl S.

Eur J Immunol. 2015 Jun;45(6):1667-79. doi: 10.1002/eji.201444915. Epub 2015 May 15.

10.

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.

Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK.

Immunity. 2014 Apr 17;40(4):477-89. doi: 10.1016/j.immuni.2014.04.004.

11.

Unconventional RORγt+ T cells drive hepatic ischemia reperfusion injury.

Eggenhofer E, Rovira J, Sabet-Baktach M, Groell A, Scherer MN, Dahlke MH, Farkas SA, Loss M, Koehl GE, Lang SA, Melter M, Schlitt HJ, Geissler EK, Kroemer A.

J Immunol. 2013 Jul 1;191(1):480-7. doi: 10.4049/jimmunol.1202975. Epub 2013 Jun 5.

12.

RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury.

Tan Z, Jiang R, Wang X, Wang Y, Lu L, Liu Q, Zheng SG, Sun B, Ryffel B.

J Mol Cell Biol. 2013 Apr;5(2):143-6. doi: 10.1093/jmcb/mjs065. Epub 2013 Jan 28. Review. No abstract available.

13.

T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour.

Nuñez S, Saez JJ, Fernandez D, Flores-Santibañez F, Alvarez K, Tejon G, Ruiz P, Maldonado P, Hidalgo Y, Manriquez V, Bono MR, Rosemblatt M, Sauma D.

Immunology. 2013 May;139(1):61-71. doi: 10.1111/imm.12055.

14.

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner NR, Mulcahy MF, Dennis KL, Scholtens D, Bentrem DJ, Phillips JD, Ham S, Sandall BP, Khan MW, Mahvi DM, Halverson AL, Stryker SJ, Boller AM, Singal A, Sneed RK, Sarraj B, Ansari MJ, Oft M, Iwakura Y, Zhou L, Bonertz A, Beckhove P, Gounari F, Khazaie K.

Sci Transl Med. 2012 Dec 12;4(164):164ra159. doi: 10.1126/scitranslmed.3004566.

15.

Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis.

Kimura K, Kanai T, Hayashi A, Mikami Y, Sujino T, Mizuno S, Handa T, Matsuoka K, Hisamatsu T, Sato T, Hibi T.

Biochem Biophys Res Commun. 2012 Nov 2;427(4):694-700. doi: 10.1016/j.bbrc.2012.09.091. Epub 2012 Sep 26.

PMID:
23022186
16.
17.

The Th17-defining transcription factor RORγt promotes glomerulonephritis.

Steinmetz OM, Summers SA, Gan PY, Semple T, Holdsworth SR, Kitching AR.

J Am Soc Nephrol. 2011 Mar;22(3):472-83. doi: 10.1681/ASN.2010040435. Epub 2010 Dec 23.

18.

ROR gamma t is dispensable for the development of intestinal mucosal T cells.

Naito T, Shiohara T, Hibi T, Suematsu M, Ishikawa H.

Mucosal Immunol. 2008 May;1(3):198-207. doi: 10.1038/mi.2008.4.

PMID:
19079179
19.

Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation.

Michel ML, Mendes-da-Cruz D, Keller AC, Lochner M, Schneider E, Dy M, Eberl G, Leite-de-Moraes MC.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19845-50. doi: 10.1073/pnas.0806472105. Epub 2008 Dec 4.

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