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Items: 1 to 20 of 124

1.

Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice.

Li Z, Liu J, Li J, Kong Y, Sandusky G, Rao X, Liu Y, Wan J, Liu X.

J Biol Chem. 2017 Oct 20;292(42):17461-17472. doi: 10.1074/jbc.M117.810960. Epub 2017 Sep 12.

2.

Delayed APC/C activation extends the first mitosis of mouse embryos.

Ajduk A, Strauss B, Pines J, Zernicka-Goetz M.

Sci Rep. 2017 Aug 29;7(1):9682. doi: 10.1038/s41598-017-09526-1.

3.

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.

de Cárcer G, Wachowicz P, Martínez-Martínez S, Oller J, Méndez-Barbero N, Escobar B, González-Loyola A, Takaki T, El Bakkali A, Cámara JA, Jiménez-Borreguero LJ, Bustelo XR, Cañamero M, Mulero F, de Los Ángeles Sevilla M, Montero MJ, Redondo JM, Malumbres M.

Nat Med. 2017 Aug;23(8):964-974. doi: 10.1038/nm.4364. Epub 2017 Jul 10.

PMID:
28692064
4.

Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies.

Wachowicz P, Fernández-Miranda G, Marugán C, Escobar B, de Cárcer G.

Bioessays. 2016 Jul;38 Suppl 1:S96-S106. doi: 10.1002/bies.201670908.

PMID:
27417127
5.

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.

Trakala M, Partida D, Salazar-Roa M, Maroto M, Wachowicz P, de Cárcer G, Malumbres M.

Blood. 2015 Oct 1;126(14):1707-14. doi: 10.1182/blood-2015-03-634402. Epub 2015 Jul 16.

6.

PLK1 regulates spindle formation kinetics and APC/C activation in mouse zygote.

Baran V, Brzakova A, Rehak P, Kovarikova V, Solc P.

Zygote. 2016 Jun;24(3):338-45. doi: 10.1017/S0967199415000246. Epub 2015 Jul 15.

PMID:
26174739
7.

Multiple requirements of PLK1 during mouse oocyte maturation.

Solc P, Kitajima TS, Yoshida S, Brzakova A, Kaido M, Baran V, Mayer A, Samalova P, Motlik J, Ellenberg J.

PLoS One. 2015 Feb 6;10(2):e0116783. doi: 10.1371/journal.pone.0116783. eCollection 2015.

8.

Excess centrosomes disrupt endothelial cell migration via centrosome scattering.

Kushner EJ, Ferro LS, Liu JY, Durrant JR, Rogers SL, Dudley AC, Bautch VL.

J Cell Biol. 2014 Jul 21;206(2):257-72. doi: 10.1083/jcb.201311013.

9.

Polo-like kinase 1 is essential for the first mitotic division in the mouse embryo.

Baran V, Solc P, Kovarikova V, Rehak P, Sutovsky P.

Mol Reprod Dev. 2013 Jul;80(7):522-34. doi: 10.1002/mrd.22188. Epub 2013 Jun 13.

PMID:
23649868
10.

Distinct set of kinases induced after retrieval of spatial memory discriminate memory modulation processes in the mouse hippocampus.

Li L, Sase A, Patil S, Sunyer B, Höger H, Smalla KH, Stork O, Lubec G.

Hippocampus. 2013 Aug;23(8):672-83. doi: 10.1002/hipo.22127. Epub 2013 May 22.

PMID:
23536525
11.

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.

Raab M, Kappel S, Krämer A, Sanhaji M, Matthess Y, Kurunci-Csacsko E, Calzada-Wack J, Rathkolb B, Rozman J, Adler T, Busch DH, Esposito I, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Sänger N, Prinz F, Angelis MH, Seibler J, Yuan J, Bergmann M, Knecht R, Kreft B, Strebhardt K.

Nat Commun. 2011 Jul 19;2:395. doi: 10.1038/ncomms1395.

12.

Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice.

Shen W, Ahmad F, Hockman S, Ma J, Omi H, Raghavachari N, Manganiello V.

Cell Cycle. 2010 Dec 1;9(23):4720-34. Epub 2010 Dec 1.

13.

Polo-like kinase1 (Plk1) knockdown enhances cisplatin chemosensitivity via up-regulation of p73α in p53 mutant human epidermoid squamous carcinoma cells.

Tyagi S, Bhui K, Singh R, Singh M, Raisuddin S, Shukla Y.

Biochem Pharmacol. 2010 Nov 1;80(9):1326-34. doi: 10.1016/j.bcp.2010.07.025. Epub 2010 Jul 22.

PMID:
20655883
14.

Functional dynamics of Polo-like kinase 1 at the centrosome.

Kishi K, van Vugt MA, Okamoto K, Hayashi Y, Yaffe MB.

Mol Cell Biol. 2009 Jun;29(11):3134-50. doi: 10.1128/MCB.01663-08. Epub 2009 Mar 23.

15.

Polo-like kinase 1 is essential for early embryonic development and tumor suppression.

Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J.

Mol Cell Biol. 2008 Nov;28(22):6870-6. doi: 10.1128/MCB.00392-08. Epub 2008 Sep 15.

16.

Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle formation during mouse oocyte meiosis.

Xiong B, Sun SC, Lin SL, Li M, Xu BZ, OuYang YC, Hou Y, Chen DY, Sun QY.

Cell Cycle. 2008 Jun 15;7(12):1804-9. Epub 2008 Jun 26.

PMID:
18583944
17.

Megakaryocyte polyploidization is associated with decreased expression of polo-like kinase (PLK).

Yagi M, Roth GJ.

J Thromb Haemost. 2006 Sep;4(9):2028-34. Epub 2006 Jun 20.

18.

Normal cells, but not cancer cells, survive severe Plk1 depletion.

Liu X, Lei M, Erikson RL.

Mol Cell Biol. 2006 Mar;26(6):2093-108.

19.

Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts.

Anger M, Kues WA, Klima J, Mielenz M, Kubelka M, Motlik J, Esner M, Dvorak P, Carnwath JW, Niemann H.

Mol Reprod Dev. 2003 Jul;65(3):245-53.

PMID:
12784245
20.

Polo-like kinase-1 is a pivotal regulator of microtubule assembly during mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis.

Tong C, Fan HY, Lian L, Li SW, Chen DY, Schatten H, Sun QY.

Biol Reprod. 2002 Aug;67(2):546-54.

PMID:
12135894

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