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Isoflurane preconditioning inhibits the effects of tissue-type plasminogen activator on brain endothelial cell in an in vitro model of ischemic stroke.

Cheon SY, Kim SY, Kam EH, Lee JH, Kim JM, Kim EJ, Kim TW, Koo BN.

Int J Med Sci. 2017 Apr 8;14(5):425-433. doi: 10.7150/ijms.18037. eCollection 2017.


Mesenchymal Stromal Cells Promote Axonal Outgrowth Alone and Synergistically with Astrocytes via tPA.

Qian JY, Chopp M, Liu Z.

PLoS One. 2016 Dec 13;11(12):e0168345. doi: 10.1371/journal.pone.0168345. eCollection 2016.


Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism.

Marcos-Contreras OA, Martinez de Lizarrondo S, Bardou I, Orset C, Pruvost M, Anfray A, Frigout Y, Hommet Y, Lebouvier L, Montaner J, Vivien D, Gauberti M.

Blood. 2016 Nov 17;128(20):2423-2434. Epub 2016 Aug 16.


The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis.

Dahl LC, Nasa Z, Chung J, Niego B, Tarlac V, Ho H, Galle A, Petratos S, Lee JY, Alderuccio F, Medcalf RL.

PLoS One. 2016 Jul 18;11(7):e0158653. doi: 10.1371/journal.pone.0158653. eCollection 2016.


Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains.

Szabo R, Samson AL, Lawrence DA, Medcalf RL, Bugge TH.

J Thromb Haemost. 2016 Aug;14(8):1618-28. doi: 10.1111/jth.13338. Epub 2016 Jun 20.


Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons.

Louessard M, Lacroix A, Martineau M, Mondielli G, Montagne A, Lesept F, Lambolez B, Cauli B, Mothet JP, Vivien D, Maubert E.

Mol Neurobiol. 2016 Sep;53(7):5000-12. doi: 10.1007/s12035-015-9432-7. Epub 2015 Sep 16.


Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator.

Lemarchand E, Gauberti M, Martinez de Lizarrondo S, Villain H, Repessé Y, Montagne A, Vivien D, Ali C, Rubio M.

Stroke. 2015 Jun;46(6):1641-50. doi: 10.1161/STROKEAHA.114.007143. Epub 2015 Apr 28.


Tissue plasminogen activator modulates emotion in a social context.

Nakamura K, Takabe A, Shimizu F, Takahashi M, Matsuo O, Mitsui S.

Behav Brain Res. 2015 Mar 15;281:24-31. doi: 10.1016/j.bbr.2014.11.022. Epub 2014 Dec 11.


Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-κB pathways.

Lin L, Jin Y, Mars WM, Reeves WB, Hu K.

Am J Pathol. 2014 Oct;184(10):2757-67. doi: 10.1016/j.ajpath.2014.06.013. Epub 2014 Aug 12.


Tissue plasminogen activator involvement in experimental autoimmune myasthenia gravis: aggravation and therapeutic potential.

Gur-Wahnon D, Mizrachi T, Wald-Altman S, Al-Roof Higazi A, Brenner T.

J Autoimmun. 2014 Aug;52:36-43. doi: 10.1016/j.jaut.2013.12.017. Epub 2014 Jan 11.


Retention of endothelial progenitor cells in bone marrow in a murine model of endogenous tissue plasminogen activator (tPA) deficiency in response to critical limb ischemia.

Leu S, Lu HI, Sun CK, Sheu JJ, Chen YL, Tsai TH, Yeh KH, Chai HT, Chua S, Tsai CY, Chang HW, Lee FY, Yip HK.

Int J Cardiol. 2014 Jan 1;170(3):394-405. doi: 10.1016/j.ijcard.2013.11.021. Epub 2013 Nov 12.


Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2-CREB-ATF3 signaling pathway.

Wu F, Echeverry R, Wu J, An J, Haile WB, Cooper DS, Catano M, Yepes M.

Mol Cell Neurosci. 2013 Jan;52:9-19. doi: 10.1016/j.mcn.2012.10.001. Epub 2012 Oct 9.


Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain.

Wu F, Wu J, Nicholson AD, Echeverry R, Haile WB, Catano M, An J, Lee AK, Duong D, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Medcalf RL, Yepes M.

J Neurosci. 2012 Jul 18;32(29):9848-58.


Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.

Bukhari N, Torres L, Robinson JK, Tsirka SE.

J Neurosci. 2011 Oct 19;31(42):14931-43. doi: 10.1523/JNEUROSCI.3339-11.2011.


Involvement of tissue plasminogen activator "tPA" in ethanol-induced locomotor sensitization and conditioned-place preference.

Bahi A, Dreyer JL.

Behav Brain Res. 2012 Jan 1;226(1):250-8. doi: 10.1016/j.bbr.2011.09.024. Epub 2011 Sep 17.


Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation.

Sashindranath M, Samson AL, Downes CE, Crack PJ, Lawrence AJ, Li QX, Ng AQ, Jones NC, Farrugia JJ, Abdella E, Vassalli JD, Madani R, Medcalf RL.

Lab Invest. 2011 Jul;91(7):1079-91. doi: 10.1038/labinvest.2011.67. Epub 2011 Apr 25.


Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice.

Noel M, Norris EH, Strickland S.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5069-74. doi: 10.1073/pnas.1017608108. Epub 2011 Mar 7.


Environmental stimulation changes tissue-type plasminogen activator activity in the adult mouse hippocampus.

Horii-Hayashi N, Yoshikawa M, Matsusue Y, Ishizaka S, Nishi M, Wanaka A.

Neurochem Int. 2011 Jan;58(1):1-4. doi: 10.1016/j.neuint.2010.10.007. Epub 2010 Oct 23.


tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway.

Lin L, Bu G, Mars WM, Reeves WB, Tanaka S, Hu K.

Am J Pathol. 2010 Oct;177(4):1687-96. doi: 10.2353/ajpath.2010.100213. Epub 2010 Aug 19.


Tissue-type plasminogen activator induces plasmin-dependent proteolysis of intracellular neuronal nitric oxide synthase.

Baron A, Hommet Y, Cassé F, Vivien D.

Biol Cell. 2010 Aug 18;102(10):539-47. doi: 10.1042/BC20100072.


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