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Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.

Xu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HP.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5086-E5095. doi: 10.1073/pnas.1712363115. Epub 2018 May 15.


Celastrol downregulates E2F1 to induce growth inhibitory effects in hepatocellular carcinoma HepG2 cells.

Ma L, Peng L, Fang S, He B, Liu Z.

Oncol Rep. 2017 Nov;38(5):2951-2958. doi: 10.3892/or.2017.5971. Epub 2017 Sep 19.


E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer.

Lopes-Ramos CM, Barros BP, Koyama FC, Carpinetti PA, Pezuk J, Doimo NTS, Habr-Gama A, Perez RO, Parmigiani RB.

PLoS One. 2017 Jul 13;12(7):e0181153. doi: 10.1371/journal.pone.0181153. eCollection 2017.


lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1.

Yu L, Fang F, Lu S, Li X, Yang Y, Wang Z.

Cancer Gene Ther. 2017 May;24(5):221-226. doi: 10.1038/cgt.2017.10. Epub 2017 Apr 21.


Expression level is a key determinant of E2F1-mediated cell fate.

Shats I, Deng M, Davidovich A, Zhang C, Kwon JS, Manandhar D, Gordân R, Yao G, You L.

Cell Death Differ. 2017 Apr;24(4):626-637. doi: 10.1038/cdd.2017.12. Epub 2017 Feb 17.


Resveratrol enhances the radiosensitivity of nasopharyngeal carcinoma cells by downregulating E2F1.

Tan Y, Wei X, Zhang W, Wang X, Wang K, Du B, Xiao J.

Oncol Rep. 2017 Mar;37(3):1833-1841. doi: 10.3892/or.2017.5413. Epub 2017 Jan 30.


Copy number variations of E2F1: a new genetic risk factor for testicular cancer.

Rocca MS, Di Nisio A, Marchiori A, Ghezzi M, Opocher G, Foresta C, Ferlin A.

Endocr Relat Cancer. 2017 Mar;24(3):119-125. doi: 10.1530/ERC-16-0514. Epub 2017 Jan 19.


A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma.

Yuan Y, Sturgis EM, Zhu L, Lu M, Li Y, Wei Q, Li G.

Mol Carcinog. 2017 Mar;56(3):1100-1106. doi: 10.1002/mc.22576. Epub 2016 Oct 20.


Characterizing Genetic Transitions of Copy Number Alterations and Allelic Imbalances in Oral Tongue Carcinoma Metastasis.

Morita T, Uzawa N, Mogushi K, Sumino J, Michikawa C, Takahashi KI, Myo K, Izumo T, Harada K.

Genes Chromosomes Cancer. 2016 Dec;55(12):975-986. doi: 10.1002/gcc.22395. Epub 2016 Aug 19.


Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage.

Bertoli C, Herlihy AE, Pennycook BR, Kriston-Vizi J, de Bruin RAM.

Cell Rep. 2016 May 17;15(7):1412-1422. doi: 10.1016/j.celrep.2016.04.036. Epub 2016 May 5.


The Role of the Transcription Factor E2F1 in Hepatocellular Carcinoma.

Farra R, Grassi G, Tonon F, Abrami M, Grassi M, Pozzato G, Fiotti N, Forte G, Dapas B.

Curr Drug Deliv. 2017;14(2):272-281. doi: 10.2174/1567201813666160527141742. Review.


Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells.

Mori K, Uchida T, Fukumura M, Tamiya S, Higurashi M, Sakai H, Ishikawa F, Shibanuma M.

Cancer Sci. 2016 Jul;107(7):963-71. doi: 10.1111/cas.12953. Epub 2016 May 20.


Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.

Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB.

Sci Adv. 2016 Feb 5;2(2):e1501257. doi: 10.1126/sciadv.1501257. eCollection 2016 Feb.


E2F1 transcription factor and its impact on growth factor and cytokine signaling.

Ertosun MG, Hapil FZ, Osman Nidai O.

Cytokine Growth Factor Rev. 2016 Oct;31:17-25. doi: 10.1016/j.cytogfr.2016.02.001. Epub 2016 Mar 2. Review.


E2F1/TS Immunophenotype and Survival of Patients with Colorectal Cancer Treated with 5FU-Based Adjuvant Therapy.

Sulzyc-Bielicka V, Domagala P, Bielicki D, Safranow K, Rogowski W, Domagala W.

Pathol Oncol Res. 2016 Jul;22(3):601-8. doi: 10.1007/s12253-016-0043-z. Epub 2016 Jan 29.


Adenovirus-Mediated E2F-1 Gene Transfer Augments Gemcitabine-Induced Apoptosis in Human Colon Cancer Cells.

Lin Z, Ren N, Jiang Y, Xu W, Shi Y, Liu G.

Clin Lab. 2015;61(10):1435-44.


The Prognostic Role and Relationship between E2F1 and SV40 in Diffuse Large B-Cell Lymphoma of Egyptian Patients.

Samaka RM, Aiad HA, Kandil MA, Asaad NY, Holah NS.

Anal Cell Pathol (Amst). 2015;2015:919834. doi: 10.1155/2015/919834. Epub 2015 Oct 27.


Emerging links between E2F control and mitochondrial function.

Benevolenskaya EV, Frolov MV.

Cancer Res. 2015 Feb 15;75(4):619-23. doi: 10.1158/0008-5472.CAN-14-2173. Epub 2015 Jan 29. Review.


E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo.

Wei WY, Yan LH, Wang XT, Li L, Cao WL, Zhang XS, Zhan ZX, Yu H, Xie YB, Xiao Q.

World J Gastroenterol. 2015 Jan 14;21(2):491-501. doi: 10.3748/wjg.v21.i2.491.


Genomic and genetic variation in E2F transcription factor-1 in men with nonobstructive azoospermia.

Jorgez CJ, Wilken N, Addai JB, Newberg J, Vangapandu HV, Pastuszak AW, Mukherjee S, Rosenfeld JA, Lipshultz LI, Lamb DJ.

Fertil Steril. 2015 Jan;103(1):44-52.e1. doi: 10.1016/j.fertnstert.2014.09.021. Epub 2014 Oct 24.

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