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Items: 1 to 20 of 257

1.

Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.

Zoghbi ME, Mok L, Swartz DJ, Singh A, Fendley GA, Urbatsch IL, Altenberg GA.

J Biol Chem. 2017 Dec 15;292(50):20412-20424. doi: 10.1074/jbc.M117.814186. Epub 2017 Oct 9.

PMID:
29018094
2.

Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice.

Erdő F, Nagy I, Tóth B, Bui A, Molnár É, Tímár Z, Magnan R, Krajcsi P.

Brain Res Bull. 2017 Jun;132:232-236. doi: 10.1016/j.brainresbull.2017.06.013. Epub 2017 Jun 16.

PMID:
28629814
3.

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein.

Verhalen B, Dastvan R, Thangapandian S, Peskova Y, Koteiche HA, Nakamoto RK, Tajkhorshid E, Mchaourab HS.

Nature. 2017 Mar 30;543(7647):738-741. doi: 10.1038/nature21414. Epub 2017 Mar 13.

4.

The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid-Antipsychotic Drug Interactions.

Brzozowska NI, de Tonnerre EJ, Li KM, Wang XS, Boucher AA, Callaghan PD, Kuligowski M, Wong A, Arnold JC.

Neuropsychopharmacology. 2017 Oct;42(11):2222-2231. doi: 10.1038/npp.2017.50. Epub 2017 Mar 8.

5.

Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics.

Zhu L, Wu J, Zhao M, Song W, Qi X, Wang Y, Lu L, Liu Z.

Toxicol Appl Pharmacol. 2017 Apr 1;320:32-39. doi: 10.1016/j.taap.2017.02.008. Epub 2017 Feb 11.

PMID:
28193520
6.

Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease.

Bruckmann S, Brenn A, Grube M, Niedrig K, Holtfreter S, von Bohlen und Halbach O, Groschup M, Keller M, Vogelgesang S.

Curr Alzheimer Res. 2017;14(6):656-667. doi: 10.2174/1567205013666161201201227.

PMID:
27915995
7.

Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function.

Yang Z, Zhou Q, Mok L, Singh A, Swartz DJ, Urbatsch IL, Brouillette CG.

Biochim Biophys Acta Biomembr. 2017 Jan;1859(1):48-60. doi: 10.1016/j.bbamem.2016.10.009. Epub 2016 Oct 23.

8.

Nilotinib reverses ABCB1/P-glycoprotein-mediated multidrug resistance but increases cardiotoxicity of doxorubicin in a MDR xenograft model.

Zhou ZY, Wan LL, Yang QJ, Han YL, Li D, Lu J, Guo C.

Toxicol Lett. 2016 Sep 30;259:124-132. doi: 10.1016/j.toxlet.2016.07.710. Epub 2016 Aug 1.

9.

Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate Has Immunomodulatory Effects on the Colon of Mice that Spontaneously Develop Colitis.

Pérez-Bosque A, Miró L, Maijó M, Polo J, Campbell JM, Russell L, Crenshaw JD, Weaver E, Moretó M.

PLoS One. 2016 May 3;11(5):e0154823. doi: 10.1371/journal.pone.0154823. eCollection 2016.

10.

Interaction of the P-Glycoprotein Multidrug Transporter with Sterols.

Clay AT, Lu P, Sharom FJ.

Biochemistry. 2015 Nov 3;54(43):6586-97. doi: 10.1021/acs.biochem.5b00904. Epub 2015 Oct 26.

PMID:
26484739
11.

A combined omics approach to evaluate the effects of dietary curcumin on colon inflammation in the Mdr1a(-/-) mouse model of inflammatory bowel disease.

Cooney JM, Barnett MP, Dommels YE, Brewster D, Butts CA, McNabb WC, Laing WA, Roy NC.

J Nutr Biochem. 2016 Jan;27:181-92. doi: 10.1016/j.jnutbio.2015.08.030. Epub 2015 Sep 13.

PMID:
26437580
12.

Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac.

Scialis RJ, Csanaky IL, Goedken MJ, Manautou JE.

Drug Metab Dispos. 2015 Jul;43(7):944-50. doi: 10.1124/dmd.114.061705. Epub 2015 Apr 20.

13.

Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis.

Pérez-Bosque A, Miró L, Maijó M, Polo J, Campbell J, Russell L, Crenshaw J, Weaver E, Moretó M.

Am J Physiol Gastrointest Liver Physiol. 2015 Jun 15;308(12):G1012-8.

14.
15.

Roles of P-glycoprotein and multidrug resistance protein in transporting para-aminosalicylic acid and its N-acetylated metabolite in mice brain.

Hong L, Xu C, O'Neal S, Bi HC, Huang M, Zheng W, Zeng S.

Acta Pharmacol Sin. 2014 Dec;35(12):1577-85. doi: 10.1038/aps.2014.103. Epub 2014 Nov 24.

16.

Brain penetration of emodepside is increased in P-glycoprotein-deficient mice and leads to neurotoxicosis.

Elmshäuser S, Straehle LC, Kranz J, Krebber R, Geyer J.

J Vet Pharmacol Ther. 2015 Feb;38(1):74-9. doi: 10.1111/jvp.12149. Epub 2014 Aug 1.

PMID:
25131706
17.

Irinotecan and temozolomide brain distribution: a focus on ABCB1.

Goldwirt L, Beccaria K, Carpentier A, Farinotti R, Fernandez C.

Cancer Chemother Pharmacol. 2014 Jul;74(1):185-93. doi: 10.1007/s00280-014-2490-0. Epub 2014 May 28.

PMID:
24867782
18.

Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice.

Bhardwaj EK, Else KJ, Rogan MT, Warhurst G.

World J Gastroenterol. 2014 Feb 21;20(7):1797-806. doi: 10.3748/wjg.v20.i7.1797.

19.

On the origin of large flexibility of P-glycoprotein in the inward-facing state.

Wen PC, Verhalen B, Wilkens S, Mchaourab HS, Tajkhorshid E.

J Biol Chem. 2013 Jun 28;288(26):19211-20. doi: 10.1074/jbc.M113.450114. Epub 2013 May 8.

20.

P-glycoprotein increases portal bioavailability of loperamide in mouse by reducing first-pass intestinal metabolism.

Dufek MB, Knight BM, Bridges AS, Thakker DR.

Drug Metab Dispos. 2013 Mar;41(3):642-50. doi: 10.1124/dmd.112.049965. Epub 2013 Jan 3.

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