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Items: 1 to 20 of 168

1.

Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice.

Choi S, Neequaye P, French SW, Gonzalez FJ, Gyamfi MA.

J Biol Chem. 2018 Jan 5;293(1):1-17. doi: 10.1074/jbc.M117.815217. Epub 2017 Nov 9.

2.

Atrazine-induced environmental nephrosis was mitigated by lycopene via modulating nuclear xenobiotic receptors-mediated response.

Xia J, Lin J, Li XN, Zhang C, Li N, Du ZH, Li YH, Li JL.

J Nutr Biochem. 2018 Jan;51:80-90. doi: 10.1016/j.jnutbio.2017.09.006. Epub 2017 Sep 21.

PMID:
29107825
3.

Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.

Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi JM, Gangarossa G, Marchi N.

Neuroscience. 2018 Feb 1;370:130-138. doi: 10.1016/j.neuroscience.2017.07.038. Epub 2017 Jul 23.

4.

Functions of pregnane X receptor in self-detoxification.

He L, Zhou X, Huang N, Li H, Li T, Yao K, Tian Y, Hu CA, Yin Y.

Amino Acids. 2017 Dec;49(12):1999-2007. doi: 10.1007/s00726-017-2435-0. Epub 2017 May 22. Review.

PMID:
28534176
5.

Pregnenolone 16╬▒-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation.

Kodama S, Shimura T, Kuribayashi H, Abe T, Yoshinari K.

Toxicol Lett. 2017 Apr 5;271:58-65. doi: 10.1016/j.toxlet.2017.02.018. Epub 2017 Feb 22.

PMID:
28237809
6.

Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.

Elentner A, Ortner D, Clausen B, Gonzalez FJ, Fernández-Salguero PM, Schmuth M, Dubrac S.

Exp Dermatol. 2015 Nov;24(11):835-40. doi: 10.1111/exd.12766. Epub 2015 Jul 14.

7.

Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.

Sui Y, Helsley RN, Park SH, Song X, Liu Z, Zhou C.

Mol Endocrinol. 2015 May;29(5):765-76. doi: 10.1210/me.2014-1355. Epub 2015 Mar 26.

8.

Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

Azuma K, Casey SC, Urano T, Horie-Inoue K, Ouchi Y, Blumberg B, Inoue S.

PLoS One. 2015 Mar 6;10(3):e0119177. doi: 10.1371/journal.pone.0119177. eCollection 2015.

9.

Activation of pregnane X receptor inhibits experimental dermal fibrosis.

Beyer C, Skapenko A, Distler A, Dees C, Reichert H, Munoz L, Leipe J, Schulze-Koops H, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2013 Apr;72(4):621-5. doi: 10.1136/annrheumdis-2012-202476. Epub 2013 Jan 4.

PMID:
23291432
10.

Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.

Poulton EJ, Levy L, Lampe JW, Shen DD, Tracy J, Shuhart MC, Thummel KE, Eaton DL.

Toxicol Appl Pharmacol. 2013 Jan 1;266(1):122-31. doi: 10.1016/j.taap.2012.10.029. Epub 2012 Nov 12.

11.

Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.

Dou W, Mukherjee S, Li H, Venkatesh M, Wang H, Kortagere S, Peleg A, Chilimuri SS, Wang ZT, Feng Y, Fearon ER, Mani S.

PLoS One. 2012;7(7):e36075. doi: 10.1371/journal.pone.0036075. Epub 2012 Jul 16.

12.

Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.

Cheng J, Krausz KW, Tanaka N, Gonzalez FJ.

Toxicol Sci. 2012 Oct;129(2):456-68. doi: 10.1093/toxsci/kfs211. Epub 2012 Jul 12.

13.

The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.

Casey SC, Blumberg B.

Mol Endocrinol. 2012 Jun;26(6):916-25. doi: 10.1210/me.2011-1303. Epub 2012 Apr 11.

14.

Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence.

Igarashi K, Kitajima S, Aisaki K, Tanemura K, Taquahashi Y, Moriyama N, Ikeno E, Matsuda N, Saga Y, Blumberg B, Kanno J.

J Toxicol Sci. 2012;37(2):373-80.

15.

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.

Krausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P.

Biochem Pharmacol. 2011 Dec 1;82(11):1771-80. doi: 10.1016/j.bcp.2011.08.023. Epub 2011 Sep 6.

16.

B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR.

Casey SC, Nelson EL, Turco GM, Janes MR, Fruman DA, Blumberg B.

Mol Endocrinol. 2011 Jun;25(6):933-43. doi: 10.1210/me.2010-0486. Epub 2011 Mar 24.

17.

Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment.

Mota LC, Barfield C, Hernandez JP, Baldwin WS.

Toxicol Appl Pharmacol. 2011 May 1;252(3):259-67. doi: 10.1016/j.taap.2011.02.017. Epub 2011 Mar 2.

18.

PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts.

He J, Nishida S, Xu M, Makishima M, Xie W.

Gastroenterology. 2011 Jun;140(7):2095-106. doi: 10.1053/j.gastro.2011.02.055. Epub 2011 Feb 24.

19.

A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.

Mongan MA, Dunn RT, Vonderfecht S, Everds N, Chen G, Su C, Higgins-Garn M, Chen Y, Afshari CA, Williamson TL, Carlock L, Dipalma C, Moss S, Bussiere J, Qualls C, He YD, Hamadeh HK.

PLoS One. 2010 Dec 21;5(12):e15595. doi: 10.1371/journal.pone.0015595.

20.

Gestational and pregnane X receptor-mediated regulation of placental ATP-binding cassette drug transporters in mice.

Gahir SS, Piquette-Miller M.

Drug Metab Dispos. 2011 Mar;39(3):465-71. doi: 10.1124/dmd.110.034983. Epub 2010 Dec 2.

PMID:
21127142

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