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Items: 1 to 20 of 394

1.

Limitations of the Pax7-creERT2 transgene for driving deletion of Nf1 in adult mouse muscle.

Summers MA, Mikulec K, Peacock L, Little DG, Schindeler A.

Int J Dev Biol. 2017;61(8-9):531-536. doi: 10.1387/ijdb.170182as.

PMID:
29139538
2.

The reduced osteogenic potential of Nf1-deficient osteoprogenitors is EGFR-independent.

Tahaei SE, Couasnay G, Ma Y, Paria N, Gu J, Lemoine BF, Wang X, Rios JJ, Elefteriou F.

Bone. 2018 Jan;106:103-111. doi: 10.1016/j.bone.2017.10.012. Epub 2017 Oct 12.

PMID:
29032173
3.
4.

Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology.

Toonen JA, Solga AC, Ma Y, Gutmann DH.

J Exp Med. 2017 Jan;214(1):17-25. doi: 10.1084/jem.20160447. Epub 2016 Dec 6.

5.

NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.

Xie K, Colgan LA, Dao MT, Muntean BS, Sutton LP, Orlandi C, Boye SL, Boye SE, Shih CC, Li Y, Xu B, Smith RG, Yasuda R, Martemyanov KA.

Curr Biol. 2016 Nov 21;26(22):2992-3003. doi: 10.1016/j.cub.2016.09.010. Epub 2016 Oct 20.

6.

NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.

Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH.

Hum Mol Genet. 2016 May 1;25(9):1703-13. doi: 10.1093/hmg/ddw039. Epub 2016 Feb 16.

7.

Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.

Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH.

Oncotarget. 2016 Feb 16;7(7):7403-14. doi: 10.18632/oncotarget.7232.

8.

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.

Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA.

Elife. 2015 Oct 13;4:e07780. doi: 10.7554/eLife.07780.

9.

Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.

Chen YH, Gianino SM, Gutmann DH.

Genes Dev. 2015 Aug 15;29(16):1677-82. doi: 10.1101/gad.261677.115. Epub 2015 Aug 13.

10.

Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells.

Zhou Y, He Y, Sharma R, Xing W, Estwick SA, Wu X, Rhodes SD, Xu M, Yang FC.

Int J Mol Sci. 2015 Jun 1;16(6):12345-59. doi: 10.3390/ijms160612345.

11.

Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis.

Rhodes SD, Yang H, Dong R, Menon K, He Y, Li Z, Chen S, Staser KW, Jiang L, Wu X, Yang X, Peng X, Mohammad KS, Guise TA, Xu M, Yang FC.

J Bone Miner Res. 2015 Oct;30(10):1840-51. doi: 10.1002/jbmr.2538. Epub 2015 May 21.

12.

Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties.

Chen YH, McGowan LD, Cimino PJ, Dahiya S, Leonard JR, Lee DY, Gutmann DH.

Cell Rep. 2015 Mar 24;10(11):1899-912. doi: 10.1016/j.celrep.2015.02.041. Epub 2015 Mar 12.

13.

NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.

Sanchez-Ortiz E, Cho W, Nazarenko I, Mo W, Chen J, Parada LF.

Genes Dev. 2014 Nov 1;28(21):2407-20. doi: 10.1101/gad.246603.114.

14.

Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males.

Sun T, Warrington NM, Luo J, Brooks MD, Dahiya S, Snyder SC, Sengupta R, Rubin JB.

J Clin Invest. 2014 Sep;124(9):4123-33. doi: 10.1172/JCI71048. Epub 2014 Aug 1.

15.

Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1.

de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F.

Nat Med. 2014 Aug;20(8):904-10. doi: 10.1038/nm.3583. Epub 2014 Jul 6. Erratum in: Nat Med. 2015 Apr;21(4):414.

16.

Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models.

Kühnisch J, Seto J, Lange C, Stumpp S, Kobus K, Grohmann J, Elefteriou F, Fratzl P, Mundlos S, Kolanczyk M.

Bone. 2014 Sep;66:155-62. doi: 10.1016/j.bone.2014.06.012. Epub 2014 Jun 17.

PMID:
24947449
17.

Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1.

Kühnisch J, Seto J, Lange C, Schrof S, Stumpp S, Kobus K, Grohmann J, Kossler N, Varga P, Osswald M, Emmerich D, Tinschert S, Thielemann F, Duda G, Seifert W, El Khassawna T, Stevenson DA, Elefteriou F, Kornak U, Raum K, Fratzl P, Mundlos S, Kolanczyk M.

PLoS One. 2014 Jan 21;9(1):e86115. doi: 10.1371/journal.pone.0086115. eCollection 2014.

18.

Ras-Mek-Erk signaling regulates Nf1 heterozygous neointima formation.

Stansfield BK, Bessler WK, Mali R, Mund JA, Downing BD, Kapur R, Ingram DA Jr.

Am J Pathol. 2014 Jan;184(1):79-85. doi: 10.1016/j.ajpath.2013.09.022. Epub 2013 Nov 7.

19.

NF1 is a critical regulator of muscle development and metabolism.

Sullivan K, El-Hoss J, Quinlan KG, Deo N, Garton F, Seto JT, Gdalevitch M, Turner N, Cooney GJ, Kolanczyk M, North KN, Little DG, Schindeler A.

Hum Mol Genet. 2014 Mar 1;23(5):1250-9. doi: 10.1093/hmg/ddt515. Epub 2013 Oct 24.

20.

p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos.

Haupaix N, Stolfi A, Sirour C, Picco V, Levine M, Christiaen L, Yasuo H.

Development. 2013 Nov;140(21):4347-52. doi: 10.1242/dev.098756. Epub 2013 Sep 25.

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