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Items: 1 to 20 of 85

1.

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver.

Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA.

J Biol Chem. 2016 Jun 24;291(26):13479-94. doi: 10.1074/jbc.M116.728469. Epub 2016 Apr 29.

2.

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.

Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H.

Biochem Biophys Res Commun. 2015 Oct 23;466(3):536-40. doi: 10.1016/j.bbrc.2015.09.065. Epub 2015 Sep 14.

PMID:
26381177
3.

Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation.

Manitsopoulos N, Orfanos SE, Kotanidou A, Nikitopoulou I, Siempos I, Magkou C, Dimopoulou I, Zakynthinos SG, Armaganidis A, Maniatis NA.

Respir Res. 2015 Feb 14;16:24. doi: 10.1186/s12931-015-0173-y.

4.

Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.

Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1824-31. doi: 10.1161/ATVBAHA.111.240754. Epub 2012 Jun 14.

PMID:
22701022
5.

Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension.

Sonawane PJ, Sahu BS, Sasi BK, Geedi P, Lenka G, Mahapatra NR.

PLoS One. 2011 Jan 31;6(1):e16661. doi: 10.1371/journal.pone.0016661.

6.

Effect of docosahexaenoic acid on brain 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in male ICR mice.

Shirai N, Suzuki H.

J Nutr Biochem. 2007 Jul;18(7):488-94. Epub 2006 Dec 4.

PMID:
17142030
7.

Purification of brain peroxisomes and localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Kovacs WJ, Faust PL, Keller GA, Krisans SK.

Eur J Biochem. 2001 Sep;268(18):4850-9.

8.

Glucocorticoid-regulated gene expression in the immune system. Analysis of glucocorticoid-regulated transcripts from the mouse macrophage-like cell line P388D1.

Helmberg A, Fässler R, Geley S, Jöhrer K, Kroemer G, Böck G, Kofler R.

J Immunol. 1990 Dec 15;145(12):4332-7.

PMID:
2258621
9.

Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis.

Lu H, Talbot S, Robertson KA, Watterson S, Forster T, Roy D, Ghazal P.

Steroids. 2015 Jul;99(Pt B):219-29. doi: 10.1016/j.steroids.2015.02.022. Epub 2015 Mar 7.

10.

Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver.

Zhang X, Song Y, Feng M, Zhou X, Lu Y, Gao L, Yu C, Jiang X, Zhao J.

J Lipid Res. 2015 May;56(5):963-71. doi: 10.1194/jlr.M047654. Epub 2015 Feb 23.

11.

Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation.

Chen Y, Ku H, Zhao L, Wheeler DC, Li LC, Li Q, Varghese Z, Moorhead JF, Powis SH, Huang A, Ruan XZ.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):365-76. doi: 10.1161/ATVBAHA.113.301301. Epub 2013 Nov 14.

PMID:
24233489
12.

Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL receptor expression.

Ying Z, Desikan R, Xu X, Maiseyeu A, Liu C, Sun Q, Ziouzenkova O, Parthasarathy S, Rajagopalan S.

J Lipid Res. 2012 May;53(5):879-87. doi: 10.1194/jlr.M022806. Epub 2012 Feb 21.

13.

Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice.

Watanabe M, Ayugase J.

J Food Sci. 2010 Nov-Dec;75(9):H294-9. doi: 10.1111/j.1750-3841.2010.01853.x.

PMID:
21535603
14.

Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.

Ding J, Jiang D, Kurczy M, Nalepka J, Dudley B, Merkel EI, Porter FD, Ewing AG, Winograd N, Burgess J, Molyneaux K.

BMC Dev Biol. 2008 Dec 31;8:120. doi: 10.1186/1471-213X-8-120.

15.

Renal ischemia-induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene.

Naito M, Bomsztyk K, Zager RA.

Am J Pathol. 2009 Jan;174(1):54-62. doi: 10.2353/ajpath.2009.080602. Epub 2008 Dec 18.

16.

Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses.

Schiefelbein D, Goren I, Fisslthaler B, Schmidt H, Geisslinger G, Pfeilschifter J, Frank S.

J Biol Chem. 2008 May 30;283(22):15479-90. doi: 10.1074/jbc.M709841200. Epub 2008 Apr 3.

17.

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.

Ohashi K, Osuga J, Tozawa R, Kitamine T, Yagyu H, Sekiya M, Tomita S, Okazaki H, Tamura Y, Yahagi N, Iizuka Y, Harada K, Gotoda T, Shimano H, Yamada N, Ishibashi S.

J Biol Chem. 2003 Oct 31;278(44):42936-41. Epub 2003 Aug 14.

18.

Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13.

Sundaresan S, Yang-Feng TL, Francke U.

Somat Cell Mol Genet. 1989 Sep;15(5):465-9.

PMID:
2781417
19.

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.

Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.

Mol Biol Cell. 2012 Dec;23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19.

20.

NRIF is a regulator of neuronal cholesterol biosynthesis genes.

Korade Z, Kenchappa RS, Mirnics K, Carter BD.

J Mol Neurosci. 2009 Jun;38(2):152-8. doi: 10.1007/s12031-008-9136-9. Epub 2008 Aug 2.

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