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1.

Iron efflux from oligodendrocytes is differentially regulated in gray and white matter.

Schulz K, Vulpe CD, Harris LZ, David S.

J Neurosci. 2011 Sep 14;31(37):13301-11. doi: 10.1523/JNEUROSCI.2838-11.2011.

2.

Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice.

Cui R, Duan XL, Anderson GJ, Qiao YT, Yu P, Qian ZM, Yoshida K, Takeda S, Guo P, Yang ZL, Chang YZ.

J Trace Elem Med Biol. 2009;23(4):290-9. doi: 10.1016/j.jtemb.2009.05.004. Epub 2009 Jun 21.

PMID:
19747625
3.

Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency.

Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD.

J Nutr. 2006 May;136(5):1236-41.

PMID:
16614410
4.

Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice.

Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, Fox TC, Usta J, Naylor CE, Evans RW, McKie AT, Anderson GJ, Vulpe CD.

Blood. 2004 May 15;103(10):3933-9. Epub 2004 Jan 29.

5.

Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.

Kuo YM, Su T, Chen H, Attieh Z, Syed BA, McKie AT, Anderson GJ, Gitschier J, Vulpe CD.

Gut. 2004 Feb;53(2):201-6.

6.

Sex-linked anemia: a hypochromic anemia of mice.

Bannerman RM, Cooper RG.

Science. 1966 Feb 4;151(3710):581-2.

PMID:
5903585
7.

Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport.

Kingston PJ, Bannerman CE, Bannerman RM.

Br J Haematol. 1978 Oct;40(2):265-76.

PMID:
708646
9.

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.

Chen M, Zheng J, Liu G, Xu E, Wang J, Fuqua BK, Vulpe CD, Anderson GJ, Chen H.

Redox Biol. 2018 Jul;17:432-439. doi: 10.1016/j.redox.2018.05.013. Epub 2018 May 31.

10.

Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.

Zheng J, Chen M, Liu G, Xu E, Chen H.

FEBS Lett. 2018 Feb;592(3):394-401. doi: 10.1002/1873-3468.12978. Epub 2018 Jan 31.

PMID:
29355933
11.

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.

Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, Liu S, Jiang R, Fuqua BK, Dunaief JL, Vulpe CD, Anderson GJ, Wang H, Chen H.

Sci Rep. 2016 Dec 19;6:39470. doi: 10.1038/srep39470.

12.

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.

Zhao L, Hadziahmetovic M, Wang C, Xu X, Song Y, Jinnah HA, Wodzinska J, Iacovelli J, Wolkow N, Krajacic P, Weissberger AC, Connelly J, Spino M, Lee MK, Connor J, Giasson B, Harris ZL, Dunaief JL.

J Neurochem. 2015 Dec;135(5):958-74. doi: 10.1111/jnc.13292. Epub 2015 Sep 29.

13.

Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.

Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, Fuqua BK, Dunaief JL, Anderson GJ, David S, Vulpe CD, Chen H.

J Nutr. 2015 May;145(5):1003-9. doi: 10.3945/jn.114.207316. Epub 2015 Mar 18.

PMID:
25788583
14.

The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.

Fuqua BK, Lu Y, Darshan D, Frazer DM, Wilkins SJ, Wolkow N, Bell AG, Hsu J, Yu CC, Chen H, Dunaief JL, Anderson GJ, Vulpe CD.

PLoS One. 2014 Jun 4;9(6):e98792. doi: 10.1371/journal.pone.0098792. eCollection 2014.

15.

Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.

Wolkow N, Song D, Song Y, Chu S, Hadziahmetovic M, Lee JC, Iacovelli J, Grieco S, Dunaief JL.

Am J Pathol. 2012 Apr;180(4):1614-24. doi: 10.1016/j.ajpath.2011.12.041. Epub 2012 Feb 17.

16.

The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.

Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Grieco S, Lee J, Lyubarsky A, Pratico D, Connelly J, Spino M, Harris ZL, Dunaief JL.

Invest Ophthalmol Vis Sci. 2011 Feb 16;52(2):959-68. doi: 10.1167/iovs.10-6207.

17.

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.

Hadziahmetovic M, Dentchev T, Song Y, Haddad N, He X, Hahn P, Pratico D, Wen R, Harris ZL, Lambris JD, Beard J, Dunaief JL.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2728-36. doi: 10.1167/iovs.07-1472. Epub 2008 Mar 7.

18.
19.

CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium.

Hinoi T, Gesina G, Akyol A, Kuick R, Hanash S, Giordano TJ, Gruber SB, Fearon ER.

Gastroenterology. 2005 Apr;128(4):946-61.

PMID:
15825077
20.

Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.

Hahn P, Qian Y, Dentchev T, Chen L, Beard J, Harris ZL, Dunaief JL.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13850-5. Epub 2004 Sep 13.

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