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Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease.

Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI.

PLoS One. 2018 Aug 17;13(8):e0200626. doi: 10.1371/journal.pone.0200626. eCollection 2018.


Early Detection of Apathetic Phenotypes in Huntington's Disease Knock-in Mice Using Open Source Tools.

Minnig S, Bragg RM, Tiwana HS, Solem WT, Hovander WS, Vik ES, Hamilton M, Legg SRW, Shuttleworth DD, Coffey SR, Cantle JP, Carroll JB.

Sci Rep. 2018 Feb 2;8(1):2304. doi: 10.1038/s41598-018-20607-7.


Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease.

Wang HB, Loh DH, Whittaker DS, Cutler T, Howland D, Colwell CS.

eNeuro. 2018 Jan 3;5(1). pii: ENEURO.0431-17.2017. doi: 10.1523/ENEURO.0431-17.2017. eCollection 2018 Jan-Feb.


mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington's disease.

Abd-Elrahman KS, Hamilton A, Hutchinson SR, Liu F, Russell RC, Ferguson SSG.

Sci Signal. 2017 Dec 19;10(510). pii: eaan6387. doi: 10.1126/scisignal.aan6387.


Disease-modifying effects of ganglioside GM1 in Huntington's disease models.

Alpaugh M, Galleguillos D, Forero J, Morales LC, Lackey SW, Kar P, Di Pardo A, Holt A, Kerr BJ, Todd KG, Baker GB, Fouad K, Sipione S.

EMBO Mol Med. 2017 Nov;9(11):1537-1557. doi: 10.15252/emmm.201707763.


The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes.

Merienne N, Vachey G, de Longprez L, Meunier C, Zimmer V, Perriard G, Canales M, Mathias A, Herrgott L, Beltraminelli T, Maulet A, Dequesne T, Pythoud C, Rey M, Pellerin L, Brouillet E, Perrier AL, du Pasquier R, Déglon N.

Cell Rep. 2017 Sep 19;20(12):2980-2991. doi: 10.1016/j.celrep.2017.08.075.


Sex-dependent behavioral impairments in the HdhQ350/+ mouse line.

Cao JK, Detloff PJ, Gardner RG, Stella N.

Behav Brain Res. 2018 Jan 30;337:34-45. doi: 10.1016/j.bbr.2017.09.026. Epub 2017 Sep 18.


Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes.

Hong Y, Zhao T, Li XJ, Li S.

J Neurosci. 2017 Sep 27;37(39):9550-9563. doi: 10.1523/JNEUROSCI.1418-17.2017. Epub 2017 Sep 11.


Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Moily NS, Ormsby AR, Stojilovic A, Ramdzan YM, Diesch J, Hannan RD, Zajac MS, Hannan AJ, Oshlack A, Hatters DM.

Mol Cell Neurosci. 2017 Sep;83:103-112. doi: 10.1016/j.mcn.2017.07.004. Epub 2017 Jul 23.


Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.

Dietrich P, Johnson IM, Alli S, Dragatsis I.

PLoS Genet. 2017 Jul 17;13(7):e1006846. doi: 10.1371/journal.pgen.1006846. eCollection 2017 Jul.


CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease.

Yang S, Chang R, Yang H, Zhao T, Hong Y, Kong HE, Sun X, Qin Z, Jin P, Li S, Li XJ.

J Clin Invest. 2017 Jun 30;127(7):2719-2724. doi: 10.1172/JCI92087. Epub 2017 Jun 19.


Alterations of striatal indirect pathway neurons precede motor deficits in two mouse models of Huntington's disease.

Sebastianutto I, Cenci MA, Fieblinger T.

Neurobiol Dis. 2017 Sep;105:117-131. doi: 10.1016/j.nbd.2017.05.011. Epub 2017 Jun 1.


Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG140 knock-in mouse model of Huntington's disease.

Stefanko DP, Shah VD, Yamasaki WK, Petzinger GM, Jakowec MW.

Neurobiol Dis. 2017 Sep;105:15-32. doi: 10.1016/j.nbd.2017.05.004. Epub 2017 May 11.


High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.

Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE.

Hum Mol Genet. 2017 Mar 1;26(5):913-922. doi: 10.1093/hmg/ddx006.


Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology.

Mao Y, Chen X, Xu M, Fujita K, Motoki K, Sasabe T, Homma H, Murata M, Tagawa K, Tamura T, Kaye J, Finkbeiner S, Blandino G, Sudol M, Okazawa H.

Hum Mol Genet. 2016 Nov 1;25(21):4749-4770. doi: 10.1093/hmg/ddw303.


A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.

Southwell AL, Skotte NH, Villanueva EB, Østergaard ME, Gu X, Kordasiewicz HB, Kay C, Cheung D, Xie Y, Waltl S, Dal Cengio L, Findlay-Black H, Doty CN, Petoukhov E, Iworima D, Slama R, Ooi J, Pouladi MA, Yang XW, Swayze EE, Seth PP, Hayden MR.

Hum Mol Genet. 2017 Mar 15;26(6):1115-1132. doi: 10.1093/hmg/ddx021.


Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington's Disease.

Rattray I, Smith EJ, Crum WR, Walker TA, Gale R, Bates GP, Modo M.

PLoS One. 2017 Jan 18;12(1):e0168556. doi: 10.1371/journal.pone.0168556. eCollection 2017.


Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington's disease.

Ouk K, Hughes S, Pothecary CA, Peirson SN, Morton AJ.

Hum Mol Genet. 2016 Nov 27;25(24). pii: ddw359. doi: 10.1093/hmg/ddw359.


Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease.

Atherton JF, McIver EL, Mullen MR, Wokosin DL, Surmeier DJ, Bevan MD.

Elife. 2016 Dec 20;5. pii: e21616. doi: 10.7554/eLife.21616.

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