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GLP-1 Elicits an Intrinsic Gut-Liver Metabolic Signal to Ameliorate Diet-Induced VLDL Overproduction and Insulin Resistance.

Khound R, Taher J, Baker C, Adeli K, Su Q.

Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):2252-2259. doi: 10.1161/ATVBAHA.117.310251. Epub 2017 Oct 26.


A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces GLP-1 Resistance through an Enteric NO-Dependent and Gut-Brain Axis Mechanism.

Grasset E, Puel A, Charpentier J, Collet X, Christensen JE, Tercé F, Burcelin R.

Cell Metab. 2017 May 2;25(5):1075-1090.e5. doi: 10.1016/j.cmet.2017.04.013. Erratum in: Cell Metab. 2017 Jul 5;26(1):278.


The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.

Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA.

Cell Metab. 2017 Apr 4;25(4):927-934.e3. doi: 10.1016/j.cmet.2017.02.008. Epub 2017 Mar 16.


Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight.

Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM.

J Clin Invest. 2017 Mar 1;127(3):1031-1045. doi: 10.1172/JCI81335. Epub 2017 Feb 20.


The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine.

van der Wielen N, Ten Klooster JP, Muckenschnabl S, Pieters R, Hendriks HF, Witkamp RF, Meijerink J.

J Nutr. 2016 Dec;146(12):2429-2435. Epub 2016 Oct 26.


Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.

Dusaulcy R, Handgraaf S, Skarupelova S, Visentin F, Vesin C, Heddad-Masson M, Reimann F, Gribble F, Philippe J, Gosmain Y.

Endocrinology. 2016 Oct;157(10):3832-3843. Epub 2016 Aug 22.


Sleeve gastrectomy activates the GLP-1 pathway in pancreatic β cells and promotes GLP-1-expressing cells differentiation in the intestinal tract.

Li F, Peng Y, Zhang M, Yang P, Qu S.

Mol Cell Endocrinol. 2016 Nov 15;436:33-40. doi: 10.1016/j.mce.2016.07.019. Epub 2016 Jul 18.


Glucagon-like peptide-1 regulates calcium homeostasis and electrophysiological activities of HL-1 cardiomyocytes.

Huang JH, Chen YC, Lee TI, Kao YH, Chazo TF, Chen SA, Chen YJ.

Peptides. 2016 Apr;78:91-8. doi: 10.1016/j.peptides.2016.02.007. Epub 2016 Feb 27.


Construction of a Fusion Peptide 5rolGLP-HV and Analysis of its Therapeutic Effect on Type 2 Diabetes Mellitus and Thrombosis in Mice.

Ni Z, Zhang Y, Wang H, Wei Y, Ma B, Hao J, Tu P, Duan H, Li X, Jiang P, Ma X, Wang B, Wu R, Zhu J, Li M.

Appl Biochem Biotechnol. 2016 Apr;179(1):59-74. doi: 10.1007/s12010-016-1979-x. Epub 2016 Jan 16.


The aglycone of ginsenoside Rg3 enables glucagon-like peptide-1 secretion in enteroendocrine cells and alleviates hyperglycemia in type 2 diabetic mice.

Kim KS, Jung Yang H, Lee IS, Kim KH, Park J, Jeong HS, Kim Y, Ahn KS, Na YC, Jang HJ.

Sci Rep. 2015 Dec 17;5:18325. doi: 10.1038/srep18325.


Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.

Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.

PLoS One. 2015 Sep 17;10(9):e0138322. doi: 10.1371/journal.pone.0138322. eCollection 2015.


Endogenous Glucagon-like Peptide-1 Suppresses High-Fat Food Intake by Reducing Synaptic Drive onto Mesolimbic Dopamine Neurons.

Wang XF, Liu JJ, Xia J, Liu J, Mirabella V, Pang ZP.

Cell Rep. 2015 Aug 4;12(5):726-33. doi: 10.1016/j.celrep.2015.06.062. Epub 2015 Jul 23.


Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides.

Takano Y, Kasai K, Takagishi Y, Kikumori T, Imai T, Murata Y, Hayashi Y.

PLoS One. 2015 Jul 20;10(7):e0133812. doi: 10.1371/journal.pone.0133812. eCollection 2015.


High fat diet impairs the function of glucagon-like peptide-1 producing L-cells.

Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM.

Peptides. 2016 Mar;77:21-7. doi: 10.1016/j.peptides.2015.06.006. Epub 2015 Jul 3.


Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice.

Pacini G, Ahrén B.

Peptides. 2015 Sep;71:66-71. doi: 10.1016/j.peptides.2015.05.010. Epub 2015 Jun 26.


GLP-2 as Beneficial Factor in the Glucose Homeostasis in Mice Fed a High Fat Diet.

Baldassano S, Rappa F, Amato A, Cappello F, Mulè F.

J Cell Physiol. 2015 Dec;230(12):3029-36. doi: 10.1002/jcp.25039.


Integrative function of adrenaline receptors for glucagon-like peptide-1 exocytosis in enteroendocrine L cell line GLUTag.

Harada K, Kitaguchi T, Tsuboi T.

Biochem Biophys Res Commun. 2015 May 15;460(4):1053-8. doi: 10.1016/j.bbrc.2015.03.151. Epub 2015 Apr 3.


Hypoxia decreases glucagon-like peptide-1 secretion from the GLUTag cell line.

Kihira Y, Burentogtokh A, Itoh M, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T.

Biol Pharm Bull. 2015;38(4):514-21. doi: 10.1248/bpb.b14-00612.


Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity.

Hwang I, Park YJ, Kim YR, Kim YN, Ka S, Lee HY, Seong JK, Seok YJ, Kim JB.

FASEB J. 2015 Jun;29(6):2397-411. doi: 10.1096/fj.14-265983. Epub 2015 Feb 20.


Targeting development of incretin-producing cells increases insulin secretion.

Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ.

J Clin Invest. 2015 Jan;125(1):379-85. doi: 10.1172/JCI75838. Epub 2014 Dec 15.

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