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Items: 1 to 20 of 87


Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection.

Winer BY, Huang T, Low BE, Avery C, Pais MA, Hrebikova G, Siu E, Chiriboga L, Wiles MV, Ploss A.

Virology. 2017 Feb;502:63-72. doi: 10.1016/j.virol.2016.12.017. Epub 2016 Dec 19.


Molecular changes associated with chronic liver damage and neoplastic lesions in a murine model of hereditary tyrosinemia type 1.

Angileri F, Roy V, Morrow G, Scoazec JY, Gadot N, Orejuela D, Tanguay RM.

Biochim Biophys Acta. 2015 Dec;1852(12):2603-17. doi: 10.1016/j.bbadis.2015.09.002. Epub 2015 Sep 7.


Bone marrow transplantation concurrently reconstitutes donor liver and immune system across host species barrier in mice.

Qi Z, Li L, Wang X, Gao X, Wang X, Wei H, Zhang J, Sun R, Tian Z.

PLoS One. 2014 Sep 5;9(9):e106791. doi: 10.1371/journal.pone.0106791. eCollection 2014.


Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG.

Nat Biotechnol. 2014 Jun;32(6):551-3. doi: 10.1038/nbt.2884. Epub 2014 Mar 30. Erratum in: Nat Biotechnol. 2014 Sep;32(9):952.


Modular assembly of transposon integratable multigene vectors using RecWay assembly.

Moriarity BS, Rahrmann EP, Keng VW, Manlove LS, Beckmann DA, Wolf NK, Khurshid T, Bell JB, Largaespada DA.

Nucleic Acids Res. 2013 Apr;41(8):e92. doi: 10.1093/nar/gkt115. Epub 2013 Feb 26.


Complete Plasmodium falciparum liver-stage development in liver-chimeric mice.

Vaughan AM, Mikolajczak SA, Wilson EM, Grompe M, Kaushansky A, Camargo N, Bial J, Ploss A, Kappe SH.

J Clin Invest. 2012 Oct;122(10):3618-28. doi: 10.1172/JCI62684. Epub 2012 Sep 10.


Impaired DNA repair and genomic stability in hereditary tyrosinemia type 1.

van Dyk E, Pretorius PJ.

Gene. 2012 Mar 1;495(1):56-61. doi: 10.1016/j.gene.2011.12.021. Epub 2011 Dec 23.


The ploidy conveyor of mature hepatocytes as a source of genetic variation.

Duncan AW, Taylor MH, Hickey RD, Hanlon Newell AE, Lenzi ML, Olson SB, Finegold MJ, Grompe M.

Nature. 2010 Oct 7;467(7316):707-10. doi: 10.1038/nature09414. Epub 2010 Sep 22.


High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice.

Eggenhofer E, Doenecke A, Renner P, Slowik P, Piso P, Geissler EK, Schlitt HJ, Dahlke MH, Popp FC.

J Gastroenterol Hepatol. 2010 May;25(5):1002-8. doi: 10.1111/j.1440-1746.2009.06156.x.


Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo.

Paulk NK, Wursthorn K, Wang Z, Finegold MJ, Kay MA, Grompe M.

Hepatology. 2010 Apr;51(4):1200-8. doi: 10.1002/hep.23481.


A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver.

Wangensteen KJ, Wilber A, Keng VW, He Z, Matise I, Wangensteen L, Carson CM, Chen Y, Steer CJ, McIvor RS, Largaespada DA, Wang X, Ekker SC.

Hepatology. 2008 May;47(5):1714-24. doi: 10.1002/hep.22195.


Rescue from neonatal death in the murine model of hereditary tyrosinemia by glutathione monoethylester and vitamin C treatment.

Langlois C, Jorquera R, Orejuela D, Bergeron A, Finegold MJ, Rhead WJ, Tanguay RM.

Mol Genet Metab. 2008 Mar;93(3):306-13. Epub 2007 Nov 26.


Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.

Bateman RL, Ashworth J, Witte JF, Baker LJ, Bhanumoorthy P, Timm DE, Hurley TD, Grompe M, McClard RW.

Biochem J. 2007 Mar 1;402(2):251-60.


Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.

Langlois C, Jorquera R, Finegold M, Shroads AL, Stacpoole PW, Tanguay RM.

Biochem Pharmacol. 2006 May 28;71(11):1648-61. Epub 2006 Apr 3.


Involvement of endoplasmic reticulum stress in hereditary tyrosinemia type I.

Bergeron A, Jorquera R, Orejuela D, Tanguay RM.

J Biol Chem. 2006 Mar 3;281(9):5329-34. Epub 2005 Nov 29.


Renal proximal tubular cells acquire resistance to cell death stimuli in mice with hereditary tyrosinemia type 1.

Luijerink MC, van Beurden EA, Malingré HE, Jacobs SM, Grompe M, Klomp LW, Berger R, van den Berg IE.

Kidney Int. 2004 Sep;66(3):990-1000.


Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.

Vogel A, van Den Berg IE, Al-Dhalimy M, Groopman J, Ou CN, Ryabinina O, Iordanov MS, Finegold M, Grompe M.

Hepatology. 2004 Feb;39(2):433-43.


Long-term therapy with NTBC and tyrosine-restricted diet in a murine model of hereditary tyrosinemia type I.

Al-Dhalimy M, Overturf K, Finegold M, Grompe M.

Mol Genet Metab. 2002 Jan;75(1):38-45.


Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor.

Bateman RL, Bhanumoorthy P, Witte JF, McClard RW, Grompe M, Timm DE.

J Biol Chem. 2001 May 4;276(18):15284-91. Epub 2001 Jan 11.


Purified hematopoietic stem cells can differentiate into hepatocytes in vivo.

Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M.

Nat Med. 2000 Nov;6(11):1229-34.


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