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Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway.

Du C, Zhang T, Xiao X, Shi Y, Duan H, Ren Y.

Biochem J. 2017 Aug 2;474(16):2733-2747. doi: 10.1042/BCJ20170272.


Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice.

Hayashi S, Oe Y, Fushima T, Sato E, Sato H, Ito S, Takahashi N.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):547-552. doi: 10.1016/j.bbrc.2016.12.108. Epub 2016 Dec 23.


Proteinase activated receptor-2 counterbalances the vascular effects of endothelin-1 in fibrotic tight-skin mice.

Roviezzo F, Brancaleone V, Mattera Iacono V, Bertolino A, De Cunto G, Vellecco V, Lungarella G, Lucattelli M, Cirino G.

Br J Pharmacol. 2017 Nov;174(22):4032-4042. doi: 10.1111/bph.13618. Epub 2016 Oct 5.


Role of PAR2 in the Development of Lower Urinary Tract Dysfunction.

Roman K, Murphy SF, Done JD, McKenna KE, Schaeffer AJ, Thumbikat P.

J Urol. 2016 Aug;196(2):588-98. doi: 10.1016/j.juro.2016.01.106. Epub 2016 Feb 6.


Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model.

Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A.

J Invest Dermatol. 2016 Jan;136(1):127-35. doi: 10.1038/JID.2015.363.


Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury.

Radulovic M, Yoon H, Wu J, Mustafa K, Fehlings MG, Scarisbrick IA.

Neurobiol Dis. 2015 Nov;83:75-89. doi: 10.1016/j.nbd.2015.08.021. Epub 2015 Aug 24.


Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2.

Muley MM, Reid AR, Botz B, Bölcskei K, Helyes Z, McDougall JJ.

Br J Pharmacol. 2016 Feb;173(4):766-77. doi: 10.1111/bph.13237. Epub 2015 Jul 31.


Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis.

Zhu Y, Pan WH, Wang XR, Liu Y, Chen M, Xu XG, Liao WQ, Hu JH.

Int Immunopharmacol. 2015 Sep;28(1):507-12. doi: 10.1016/j.intimp.2015.04.047. Epub 2015 Jun 3.


A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance.

Sherwood CL, Daines MO, Price TJ, Vagner J, Boitano S.

Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C718-26. doi: 10.1152/ajpcell.00257.2014.


Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.

Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW.

Br J Pharmacol. 2014 Aug;171(16):3814-26. doi: 10.1111/bph.12738.


Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2.

Park MK, Cho MK, Kang SA, Park HK, Kim DH, Yu HS.

PLoS One. 2014 Mar 21;9(3):e92726. doi: 10.1371/journal.pone.0092726. eCollection 2014.


Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice.

Post S, Heijink IH, Petersen AH, de Bruin HG, van Oosterhout AJ, Nawijn MC.

PLoS One. 2014 Mar 20;9(3):e91206. doi: 10.1371/journal.pone.0091206. eCollection 2014.


Protease activated receptor-2 contributes to heart failure.

Antoniak S, Sparkenbaugh EM, Tencati M, Rojas M, Mackman N, Pawlinski R.

PLoS One. 2013 Nov 27;8(11):e81733. doi: 10.1371/journal.pone.0081733. eCollection 2013.


Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation.

de Boer JD, Van't Veer C, Stroo I, van der Meer AJ, de Vos AF, van der Zee JS, Roelofs JJ, van der Poll T.

Innate Immun. 2014 Aug;20(6):618-25. doi: 10.1177/1753425913503387. Epub 2013 Sep 18.


Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2.

Valdez-Morales EE, Overington J, Guerrero-Alba R, Ochoa-Cortes F, Ibeakanma CO, Spreadbury I, Bunnett NW, Beyak M, Vanner SJ.

Am J Gastroenterol. 2013 Oct;108(10):1634-43. doi: 10.1038/ajg.2013.241. Epub 2013 Aug 20.


Protease-activated receptor 2 in dorsal root ganglion contributes to peripheral sensitization of bone cancer pain.

Liu S, Liu YP, Yue DM, Liu GJ.

Eur J Pain. 2014 Mar;18(3):326-37. doi: 10.1002/j.1532-2149.2013.00372.x. Epub 2013 Jul 28.


Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice.

Hennessey JC, McGuire JJ.

PLoS One. 2013;8(2):e55965. doi: 10.1371/journal.pone.0055965. Epub 2013 Feb 7.


Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis.

Michael ES, Kuliopulos A, Covic L, Steer ML, Perides G.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G516-26. doi: 10.1152/ajpgi.00296.2012. Epub 2012 Dec 28.


Critical role of protease-activated receptor 2 activation by mast cell tryptase in the development of postoperative pain.

Oliveira SM, Silva CR, Ferreira J.

Anesthesiology. 2013 Mar;118(3):679-90. doi: 10.1097/ALN.0b013e31827d415f.


Novel animal models of acute and chronic cancer pain: a pivotal role for PAR2.

Lam DK, Dang D, Zhang J, Dolan JC, Schmidt BL.

J Neurosci. 2012 Oct 10;32(41):14178-83. doi: 10.1523/JNEUROSCI.2399-12.2012.

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