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Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait.

Peng J, Ferent J, Li Q, Liu M, Da Silva RV, Zeilhofer HU, Kania A, Zhang Y, Charron F.

Dev Dyn. 2018 Apr;247(4):620-629. doi: 10.1002/dvdy.24549. Epub 2018 Feb 5.


Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice.

Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA.

J Assoc Res Otolaryngol. 2016 Oct;17(5):417-31. doi: 10.1007/s10162-016-0578-4. Epub 2016 Aug 18.


dcc Haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking.

Reynolds LM, Gifuni AJ, McCrea ET, Shizgal P, Flores C.

Behav Brain Res. 2016 Feb 1;298(Pt A):27-31. doi: 10.1016/j.bbr.2015.05.020. Epub 2015 May 22.


Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.

Bull SJ, Bin JM, Beaumont E, Boutet A, Krimpenfort P, Sadikot AF, Kennedy TE.

J Neurosci. 2014 Jul 16;34(29):9768-78. doi: 10.1523/JNEUROSCI.0448-14.2014.


The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.

Liang DY, Zheng M, Sun Y, Sahbaie P, Low SA, Peltz G, Scherrer G, Flores C, Clark JD.

BMC Genomics. 2014 May 8;15:345. doi: 10.1186/1471-2164-15-345.


dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.

Manitt C, Eng C, Pokinko M, Ryan RT, Torres-Berrío A, Lopez JP, Yogendran SV, Daubaras MJ, Grant A, Schmidt ER, Tronche F, Krimpenfort P, Cooper HM, Pasterkamp RJ, Kolb B, Turecki G, Wong TP, Nestler EJ, Giros B, Flores C.

Transl Psychiatry. 2013 Dec 17;3:e338. doi: 10.1038/tp.2013.105.


Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine.

Kim JH, Lavan D, Chen N, Flores C, Cooper H, Lawrence AJ.

Psychopharmacology (Berl). 2013 Dec;230(4):607-16. doi: 10.1007/s00213-013-3187-5. Epub 2013 Jul 3.


N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.

Chen Q, Sun X, Zhou XH, Liu JH, Wu J, Zhang Y, Wang JH.

J Cell Sci. 2013 Jan 1;126(Pt 1):186-95. doi: 10.1242/jcs.111278. Epub 2012 Oct 4.


The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry.

Manitt C, Mimee A, Eng C, Pokinko M, Stroh T, Cooper HM, Kolb B, Flores C.

J Neurosci. 2011 Jun 8;31(23):8381-94. doi: 10.1523/JNEUROSCI.0606-11.2011.


Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine.

Yetnikoff L, Eng C, Benning S, Flores C.

Eur J Neurosci. 2010 Apr;31(7):1292-302. doi: 10.1111/j.1460-9568.2010.07163.x. Epub 2010 Mar 19.


Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice.

Grant A, Speed Z, Labelle-Dumais C, Flores C.

Eur J Neurosci. 2009 Oct;30(7):1318-28. doi: 10.1111/j.1460-9568.2009.06919.x. Epub 2009 Sep 24.


Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine.

Grant A, Hoops D, Labelle-Dumais C, Prévost M, Rajabi H, Kolb B, Stewart J, Arvanitogiannis A, Flores C.

Eur J Neurosci. 2007 Dec;26(11):3215-28. Epub 2007 Nov 14.


Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine.

Flores C, Manitt C, Rodaros D, Thompson KM, Rajabi H, Luk KC, Tritsch NX, Sadikot AF, Stewart J, Kennedy TE.

Mol Psychiatry. 2005 Jun;10(6):606-12.


Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo.

Cooper HM, Armes P, Britto J, Gad J, Wilks AF.

Oncogene. 1995 Dec 7;11(11):2243-54.


The dcc mutation affects ciliary length in Tetrahymena thermophila.

Gitz DL, Eells JB, Pennock DG.

J Eukaryot Microbiol. 1993 Sep-Oct;40(5):668-76.


DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity.

Castillo-Paterna M, Moreno-Juan V, Filipchuk A, Rodríguez-Malmierca L, Susín R, López-Bendito G.

EMBO Rep. 2015 Jul;16(7):851-62. doi: 10.15252/embr.201439882. Epub 2015 May 6.


Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy.

Bouhidel JO, Wang P, Siu KL, Li H, Youn JY, Cai H.

Biochim Biophys Acta. 2015 Feb;1852(2):277-89. doi: 10.1016/j.bbadis.2014.06.005. Epub 2014 Jun 10.


unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.

Auger ML, Schmidt ER, Manitt C, Dal-Bo G, Pasterkamp RJ, Flores C.

Eur J Neurosci. 2013 Sep;38(6):2853-63. doi: 10.1111/ejn.12270. Epub 2013 Jun 5.


Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance.

Qu C, Dwyer T, Shao Q, Yang T, Huang H, Liu G.

J Cell Sci. 2013 Jul 15;126(Pt 14):3070-81. doi: 10.1242/jcs.122184. Epub 2013 May 2.


DCC expression by neurons regulates synaptic plasticity in the adult brain.

Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE.

Cell Rep. 2013 Jan 31;3(1):173-85. doi: 10.1016/j.celrep.2012.12.005. Epub 2013 Jan 3.

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