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Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.

Jeggle P, Hofschröer V, Maase M, Bertog M, Kusche-Vihrog K.

FASEB J. 2016 Jan;30(1):45-53. doi: 10.1096/fj.14-259606. Epub 2015 Aug 31.


Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.

Adam O, Zimmer C, Hanke N, Hartmann RW, Klemmer B, Böhm M, Laufs U.

J Mol Cell Cardiol. 2015 Aug;85:140-50. doi: 10.1016/j.yjmcc.2015.05.019. Epub 2015 Jun 3.


Procollagen I-expressing renin cell precursors.

Karger C, Kurtz F, Steppan D, Schwarzensteiner I, Machura K, Angel P, Banas B, Risteli J, Kurtz A.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F355-61. doi: 10.1152/ajprenal.00079.2013. Epub 2013 Jun 12.


Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.

Luo P, Dematteo A, Wang Z, Zhu L, Wang A, Kim HS, Pozzi A, Stafford JM, Luther JM.

Diabetologia. 2013 Apr;56(4):901-10. doi: 10.1007/s00125-012-2814-8. Epub 2013 Jan 12.


Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.

Nesterov V, Dahlmann A, Krueger B, Bertog M, Loffing J, Korbmacher C.

Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1289-99. doi: 10.1152/ajprenal.00247.2012. Epub 2012 Aug 29.


Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.

Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown NJ.

Kidney Int. 2012 Sep;82(6):643-51. doi: 10.1038/ki.2012.170. Epub 2012 May 23.


Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.

Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ.

Diabetologia. 2011 Aug;54(8):2152-63. doi: 10.1007/s00125-011-2158-9. Epub 2011 Apr 26.


Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.

Makhanova N, Hagaman J, Kim HS, Smithies O.

Hypertension. 2008 Jan;51(1):134-40. Epub 2007 Nov 26.


Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.

Makhanova N, Sequeira-Lopez ML, Gomez RA, Kim HS, Smithies O.

Hypertension. 2006 Dec;48(6):1151-9. Epub 2006 Oct 30.


Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.

Lee G, Makhanova N, Caron K, Lopez ML, Gomez RA, Smithies O, Kim HS.

Endocrinology. 2005 Jun;146(6):2650-6. Epub 2005 Feb 24.


Control of renin secretion from kidneys with renin cell hyperplasia.

Kurt B, Karger C, Wagner C, Kurtz A.

Am J Physiol Renal Physiol. 2014 Feb 1;306(3):F327-32. doi: 10.1152/ajprenal.00536.2013. Epub 2013 Nov 27.


Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.

Martinerie L, Viengchareun S, Meduri G, Kim HS, Luther JM, Lombès M.

Endocrinology. 2011 Jun;152(6):2483-91. doi: 10.1210/en.2010-1460. Epub 2011 Apr 5.


Tissue kallikrein permits early renal adaptation to potassium load.

El Moghrabi S, Houillier P, Picard N, Sohet F, Wootla B, Bloch-Faure M, Leviel F, Cheval L, Frische S, Meneton P, Eladari D, Chambrey R.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13526-31. doi: 10.1073/pnas.0913070107. Epub 2010 Jul 12.


Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.

Ambroisine ML, Favre J, Oliviero P, Rodriguez C, Gao J, Thuillez C, Samuel JL, Richard V, Delcayre C.

Circulation. 2007 Nov 20;116(21):2435-43. Epub 2007 Nov 5.


Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.

Takase M, Ukena K, Tsutsui K.

Brain Res. 2002 Sep 20;950(1-2):288-96.


Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.

Mouw AR, Rice DA, Meade JC, Chua SC, White PC, Schimmer BP, Parker KL.

J Biol Chem. 1989 Jan 15;264(2):1305-9.


The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion.

Machura K, Iankilevitch E, Neubauer B, Theuring F, Kurtz A.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F578-84. doi: 10.1152/ajprenal.00617.2012. Epub 2013 Jan 9.


Kidney function in mice lacking aldosterone.

Makhanova N, Lee G, Takahashi N, Sequeira Lopez ML, Gomez RA, Kim HS, Smithies O.

Am J Physiol Renal Physiol. 2006 Jan;290(1):F61-9. Epub 2005 Aug 23.


Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.

Bogerd AM, Franklin A, Rice DA, Schimmer BP, Parker KL.

Mol Endocrinol. 1990 Jun;4(6):845-50.


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