Sort by
Items per page

Send to

Choose Destination

Links from Gene

Items: 1 to 20 of 227


Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen.

Mouri Y, Ueda Y, Yamano T, Matsumoto M, Tsuneyama K, Kinashi T, Matsumoto M.

J Immunol. 2017 Dec 15;199(12):3959-3971. doi: 10.4049/jimmunol.1700892. Epub 2017 Nov 3.


Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome.

Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA.

PLoS One. 2017 Sep 19;12(9):e0184916. doi: 10.1371/journal.pone.0184916. eCollection 2017.


AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma.

Conteduca G, Fenoglio D, Parodi A, Battaglia F, Kalli F, Negrini S, Tardito S, Ferrera F, Salis A, Millo E, Pasquale G, Barra G, Damonte G, Indiveri F, Ferrone S, Filaci G.

Oncotarget. 2016 Sep 20;7(38):60872-60884. doi: 10.18632/oncotarget.11506.


Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction.

Pezzi N, Assis AF, Cotrim-Sousa LC, Lopes GS, Mosella MS, Lima DS, Bombonato-Prado KF, Passos GA.

Mol Immunol. 2016 Sep;77:157-73. doi: 10.1016/j.molimm.2016.08.003. Epub 2016 Aug 8.


Autoimmune Regulator (AIRE) Is Expressed in Spermatogenic Cells, and It Altered the Expression of Several Nucleic-Acid-Binding and Cytoskeletal Proteins in Germ Cell 1 Spermatogonial (GC1-spg) Cells.

Radhakrishnan K, Bhagya KP, Kumar AT, Devi AN, Sengottaiyan J, Kumar PG.

Mol Cell Proteomics. 2016 Aug;15(8):2686-98. doi: 10.1074/mcp.M115.052951. Epub 2016 Jun 8.


Aire-Overexpressing Dendritic Cells Induce Peripheral CD4⁺ T Cell Tolerance.

Li D, Li H, Fu H, Niu K, Guo Y, Guo C, Sun J, Li Y, Yang W.

Int J Mol Sci. 2015 Dec 29;17(1). pii: E38. doi: 10.3390/ijms17010038.


Autoimmune regulator‑overexpressing dendritic cells induce T helper 1 and T helper 17 cells by upregulating cytokine expression.

Li H, Li D, Sun J, Li Y, Yang W, Li Y.

Mol Med Rep. 2016 Jan;13(1):565-71. doi: 10.3892/mmr.2015.4530. Epub 2015 Nov 6.


Identification of a novel cis-regulatory element essential for immune tolerance.

LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS.

J Exp Med. 2015 Nov 16;212(12):1993-2002. doi: 10.1084/jem.20151069. Epub 2015 Nov 2.


Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla.

Nishijima H, Kitano S, Miyachi H, Morimoto J, Kawano H, Hirota F, Morita R, Mouri Y, Masuda K, Imoto I, Ikuta K, Matsumoto M.

J Immunol. 2015 Nov 15;195(10):4641-9. doi: 10.4049/jimmunol.1501026. Epub 2015 Oct 9.


A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice.

Haljasorg U, Bichele R, Saare M, Guha M, Maslovskaja J, Kõnd K, Remm A, Pihlap M, Tomson L, Kisand K, Laan M, Peterson P.

Eur J Immunol. 2015 Dec;45(12):3246-56. doi: 10.1002/eji.201545928. Epub 2015 Oct 26. Review.


Aire controls gene expression in the thymic epithelium with ordered stochasticity.

Meredith M, Zemmour D, Mathis D, Benoist C.

Nat Immunol. 2015 Sep;16(9):942-9. doi: 10.1038/ni.3247. Epub 2015 Aug 3.


Lymphopenia-induced proliferation in the absence of functional Autoimmune regulator (Aire) induces colitis in mice.

Kekäläinen E, Lehto MK, Smeds E, Pöntynen N, Pekkarinen PT, Ulmanen I, Miettinen A, Arstila TP.

Immunol Lett. 2015 Sep;167(1):17-22. doi: 10.1016/j.imlet.2015.06.010. Epub 2015 Jun 22.


Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L.

Immunity. 2015 Jun 16;42(6):1048-61. doi: 10.1016/j.immuni.2015.05.013. Epub 2015 Jun 9.


Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells.

St-Pierre C, Trofimov A, Brochu S, Lemieux S, Perreault C.

J Immunol. 2015 Jul 15;195(2):498-506. doi: 10.4049/jimmunol.1500558. Epub 2015 Jun 1.


Autoimmunity, Not a Developmental Defect, is the Cause for Subfertility of Autoimmune Regulator (Aire) Deficient Mice.

Kekäläinen E, Pöntynen N, Meri S, Arstila TP, Jarva H.

Scand J Immunol. 2015 May;81(5):298-304. doi: 10.1111/sji.12280.


Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus.

Perry JSA, Lio CJ, Kau AL, Nutsch K, Yang Z, Gordon JI, Murphy KM, Hsieh CS.

Immunity. 2014 Sep 18;41(3):414-426. doi: 10.1016/j.immuni.2014.08.007. Epub 2014 Sep 11.


Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein.

Chen J, Qian H, Horai R, Chan CC, Falick Y, Caspi RR.

PLoS One. 2013 Aug 28;8(8):e72161. doi: 10.1371/journal.pone.0072161. eCollection 2013.


Autoimmune gastro-pancreatitis with anti-protein disulfide isomerase-associated 2 autoantibody in Aire-deficient BALB/cAnN mice.

Kurisaki H, Nagao Y, Nagafuchi S, Mitsuyama M.

PLoS One. 2013 Aug 26;8(8):e73862. doi: 10.1371/journal.pone.0073862. eCollection 2013.


Autoimmune regulator, Aire, is a novel regulator of chondrocyte differentiation.

Si Y, Inoue K, Igarashi K, Kanno J, Imai Y.

Biochem Biophys Res Commun. 2013 Aug 9;437(4):579-84. doi: 10.1016/j.bbrc.2013.07.001. Epub 2013 Jul 11.


Supplemental Content

Support Center