Sort by
Items per page

Send to

Choose Destination

Links from Gene

Items: 1 to 20 of 63


Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.

Zhang XF, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Wang DD, Jiang SS, Zheng HX, Lv L, Chen CL, Zhang HX, Xia JC.

Mol Carcinog. 2016 Jan;55(1):64-76. doi: 10.1002/mc.22259. Epub 2015 Jan 3.


UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors.

Zage PE, Sirisaengtaksin N, Liu Y, Gireud M, Brown BS, Palla S, Richards KN, Hughes DP, Bean AJ.

Cancer. 2013 Feb 15;119(4):915-23. doi: 10.1002/cncr.27785. Epub 2012 Sep 18.


The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death.

Spinette S, Mahoney JA, Rosen A.

Biochem Biophys Res Commun. 2006 Sep 8;347(4):1103-12. Epub 2006 Jul 14.


Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2.

Krona C, Ejeskär K, Abel F, Kogner P, Bjelke J, Björk E, Sjöberg RM, Martinsson T.

Oncogene. 2003 Apr 17;22(15):2343-51.


Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line.

Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Shishikura T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Tomioka N, Sakiyama S, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa I, Nakagawara A.

Oncogene. 2000 Aug 31;19(37):4302-7.


Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B.

Soss SE, Klevit RE, Chazin WJ.

Biochemistry. 2013 Apr 30;52(17):2991-9. doi: 10.1021/bi3015949. Epub 2013 Apr 15.


U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha.

Chatterjee A, Upadhyay S, Chang X, Nagpal JK, Trink B, Sidransky D.

Cell Cycle. 2008 May 1;7(9):1231-7. Epub 2008 Feb 19.


UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination.

Hosoda M, Ozaki T, Miyazaki K, Hayashi S, Furuya K, Watanabe K, Nakagawa T, Hanamoto T, Todo S, Nakagawara A.

Oncogene. 2005 Nov 3;24(48):7156-69.


MicroRNA-1301 suppresses tumor cell migration and invasion by targeting the p53/UBE4B pathway in multiple human cancer cells.

Wang B, Wu H, Chai C, Lewis J, Pichiorri F, Eisenstat DD, Pomeroy SL, Leng RP.

Cancer Lett. 2017 Aug 10;401:20-32. doi: 10.1016/j.canlet.2017.04.038. Epub 2017 May 5.


UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation.

Du C, Wu H, Leng RP.

Oncotarget. 2016 Jan 19;7(3):2823-36. doi: 10.18632/oncotarget.6555.


Regulation of p53 level by UBE4B in breast cancer.

Zhang Y, Lv Y, Zhang Y, Gao H.

PLoS One. 2014 Feb 26;9(2):e90154. doi: 10.1371/journal.pone.0090154. eCollection 2014. Erratum in: PLoS One. 2015;10(4):e0125136. PLoS One. 2014;9(6):e99968.


Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.

Zhang H, Zhai Y, Hu Z, Wu C, Qian J, Jia W, Ma F, Huang W, Yu L, Yue W, Wang Z, Li P, Zhang Y, Liang R, Wei Z, Cui Y, Xie W, Cai M, Yu X, Yuan Y, Xia X, Zhang X, Yang H, Qiu W, Yang J, Gong F, Chen M, Shen H, Lin D, Zeng YX, He F, Zhou G.

Nat Genet. 2010 Sep;42(9):755-8. doi: 10.1038/ng.638. Epub 2010 Aug 1.


Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.

Goh AM, Walters KJ, Elsasser S, Verma R, Deshaies RJ, Finley D, Howley PM.

BMC Biochem. 2008 Jan 30;9:4. doi: 10.1186/1471-2091-9-4.


A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.

Gabrielsen M, Buetow L, Nakasone MA, Ahmed SF, Sibbet GJ, Smith BO, Zhang W, Sidhu SS, Huang DT.

Mol Cell. 2017 Oct 19;68(2):456-470.e10. doi: 10.1016/j.molcel.2017.09.027.


UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation.

Sirisaengtaksin N, Gireud M, Yan Q, Kubota Y, Meza D, Waymire JC, Zage PE, Bean AJ.

J Biol Chem. 2014 Jan 31;289(5):3026-39. doi: 10.1074/jbc.M113.495671. Epub 2013 Dec 16.


UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.

Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP.

Nat Med. 2011 Mar;17(3):347-55. doi: 10.1038/nm.2283. Epub 2011 Feb 13.


Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.

Benirschke RC, Thompson JR, Nominé Y, Wasielewski E, Juranić N, Macura S, Hatakeyama S, Nakayama KI, Botuyan MV, Mer G.

Structure. 2010 Aug 11;18(8):955-65. doi: 10.1016/j.str.2010.04.017.


Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins.

Morreale G, Conforti L, Coadwell J, Wilbrey AL, Coleman MP.

FEBS J. 2009 Mar;276(5):1208-20. doi: 10.1111/j.1742-4658.2008.06858.x.


Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.

Yoo NJ, Park SW, Lee SH.

Pathology. 2011 Dec;43(7):753-5. doi: 10.1097/PAT.0b013e32834c7e78. No abstract available.


Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.

Böhm S, Lamberti G, Fernández-Sáiz V, Stapf C, Buchberger A.

Mol Cell Biol. 2011 Apr;31(7):1528-39. doi: 10.1128/MCB.00962-10. Epub 2011 Jan 31.

Supplemental Content

Support Center