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Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer.

Quadri HS, Aiken TJ, Allgaeuer M, Moravec R, Altekruse S, Hussain SP, Miettinen MM, Hewitt SM, Rudloff U.

BMC Cancer. 2017 Jul 21;17(1):495. doi: 10.1186/s12885-017-3481-4.


Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.

Fischer A, Brummer T, Warscheid B, Radziwill G.

Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2847-55. doi: 10.1016/j.bbamcr.2015.08.014. Epub 2015 Aug 28.


The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling.

Lim J, Zhou M, Veenstra TD, Morrison DK.

Genes Dev. 2010 Jul 15;24(14):1496-506. doi: 10.1101/gad.1904610.


CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling.

Fritz RD, Radziwill G.

Mol Cancer Res. 2010 Mar;8(3):395-406. doi: 10.1158/1541-7786.MCR-09-0296. Epub 2010 Mar 2.


AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1.

Fischer A, Weber W, Warscheid B, Radziwill G.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):89-100. doi: 10.1016/j.bbamcr.2016.10.009. Epub 2016 Oct 18.


CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis.

Fritz RD, Varga Z, Radziwill G.

Oncogene. 2010 Jun 17;29(24):3575-82. doi: 10.1038/onc.2010.104. Epub 2010 Apr 12.


CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.

Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2836-41. doi: 10.1073/pnas.0709705105. Epub 2008 Feb 19.


CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation.

Ziogas A, Moelling K, Radziwill G.

J Biol Chem. 2005 Jun 24;280(25):24205-11. Epub 2005 Apr 21.


Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.

Fischer A, Warscheid B, Weber W, Radziwill G.

Sci Rep. 2016 Nov 30;6:38155. doi: 10.1038/srep38155.


EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation.

Cho HJ, Hwang YS, Mood K, Ji YJ, Lim J, Morrison DK, Daar IO.

J Biol Chem. 2014 Jun 27;289(26):18556-68. doi: 10.1074/jbc.M114.558809. Epub 2014 May 13.


CNK1 and other scaffolds for Akt/FoxO signaling.

Fritz RD, Radziwill G.

Biochim Biophys Acta. 2011 Nov;1813(11):1971-7. doi: 10.1016/j.bbamcr.2011.02.008. Epub 2011 Feb 12. Review.


CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.

Attar MA, Salem JC, Pursel HS, Santy LC.

Exp Cell Res. 2012 Feb 1;318(3):228-37. doi: 10.1016/j.yexcr.2011.10.018. Epub 2011 Nov 7.


The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor.

Fritz RD, Radziwill G.

Biochem Biophys Res Commun. 2005 Dec 30;338(4):1906-12. Epub 2005 Nov 9.


Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.

Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TB.

Nat Immunol. 2009 Oct;10(10):1081-8. doi: 10.1038/ni.1778. Epub 2009 Aug 30.


KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.

Clapéron A, Therrien M.

Oncogene. 2007 May 14;26(22):3143-58. Review.


Murine Ksr interacts with MEK and inhibits Ras-induced transformation.

Denouel-Galy A, Douville EM, Warne PH, Papin C, Laugier D, Calothy G, Downward J, Eychène A.

Curr Biol. 1998 Jan 1;8(1):46-55.


Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.

Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ.

FEBS Lett. 2005 Jan 31;579(3):648-54.


The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.

Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B.

J Biol Chem. 2004 Jul 9;279(28):29247-54. Epub 2004 Apr 9.

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