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J Neurosci. 1998 Jun 15;18(12):4785-99.

Synaptic depression and the temporal response characteristics of V1 cells.

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1
Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02254-9110, USA.

Abstract

We explore the effects of short-term synaptic depression on the temporal dynamics of V1 responses to visual images by constructing a model simple cell. Synaptic depression is modeled on the basis of previous detailed fits to experimental data. A component of synaptic depression operating in the range of hundreds of milliseconds can account for a number of the unique temporal characteristics of cortical neurons, including the bandpass nature of frequency-response curves, increases in response amplitude and in cutoff frequency for transient stimuli, nonlinear temporal summation, and contrast-dependent shifts in response phase. Synaptic depression also provides a mechanism for generating the temporal phase shifts needed to produce direction selectivity, and a model constructed along these lines matches both extracellular and intracellular data. A slower component of depression can reproduce the effects of contrast adaptation.

PMID:
9614252
[Indexed for MEDLINE]
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