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Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15417-22.

Functional reorganization in thalamocortical networks: transition between spindling and delta sleep rhythms.

Author information

1
Department of Mathematics, Boston University, MA 02215, USA.

Abstract

Thalamic reticularis, thalamocortical, and cortical cells participate in the 7-14-hz spindling rhythm of early sleep and the slower delta rhythms of deeper sleep, with different firing patterns. In this case study, showing the interactions of intrinsic and synaptic properties, a change in the conductance of one kind of cell effectively rewires the thalamocortical circuit, leading to the transition from the spindling to the delta rhythm. The two rhythms make different uses of the fast (GABAA) and slow (GABAB) inhibition generated by the thalamic reticularis cells.

PMID:
8986826
PMCID:
PMC26419
DOI:
10.1073/pnas.93.26.15417
[Indexed for MEDLINE]
Free PMC Article

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