Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections

Nat Neurosci. 2017 Jan;20(1):16-19. doi: 10.1038/nn.4447. Epub 2016 Nov 28.

Abstract

The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / physiology
  • Entorhinal Cortex / physiology*
  • Hippocampus / physiology*
  • Interneurons / metabolism
  • Locomotion / physiology*
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Net / physiology
  • Neurons / physiology*
  • Pyramidal Cells / metabolism
  • Synaptic Transmission / physiology*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • gamma-Aminobutyric Acid