Send to

Choose Destination
Braz J Med Biol Res. 1990;23(5):473-6.

Effect of Na+ and Cl- on the velocity of propagation of the spreading depression in chick retina.

Author information

Departamento de Neurobiologia, Universidade Federal Fluminense, Niteroi, RJ, Brasil.


The chick retina in vitro preparation was used to quantify the effect of Na+ and Cl- on the velocity of propagation of spreading depression (SD). The progressive reduction of chloride concentration in the superfusing Ringer solution, either by partial removal of NaCl or by its partial substitution with isethionate, caused a logarithmic increase in the velocity of propagation of SD. Substituting Tris for Na+ had no appreciable effect on propagation velocity, suggesting that the propagation of the reaction is not necessarily dependent on Na+. However, choline did not substitute for Na+ because it decreased propagation velocity and, at higher concentrations, even blocked the spread of the reaction.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center