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J Comput Neurosci. 2009 Apr;26(2):289-301. doi: 10.1007/s10827-008-0111-9. Epub 2008 Sep 11.

The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons.

Author information

1
Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. stiefel@salk.edu

Abstract

The response of an oscillator to perturbations is described by its phase-response curve (PRC), which is related to the type of bifurcation leading from rest to tonic spiking. In a recent experimental study, we have shown that the type of PRC in cortical pyramidal neurons can be switched by cholinergic neuromodulation from type II (biphasic) to type I (monophasic). We explored how intrinsic mechanisms affected by acetylcholine influence the PRC using three different types of neuronal models: a theta neuron, single-compartment neurons and a multi-compartment neuron. In all of these models a decrease in the amount of a spike-frequency adaptation current was a necessary and sufficient condition for the shape of the PRC to change from biphasic (type II) to purely positive (type I).

PMID:
18784991
PMCID:
PMC2857973
DOI:
10.1007/s10827-008-0111-9
[Indexed for MEDLINE]
Free PMC Article

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