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Curr Opin Neurobiol. 2007 Jun;17(3):345-51. Epub 2007 Apr 23.

Ca(2+) signaling in dendritic spines.

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Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.


Recent studies have revealed that Ca(2+) signals evoked by action potentials or by synaptic activity within individual dendritic spines are regulated at multiple levels. Ca(2+) influx through glutamate receptors and voltage-sensitive Ca(2+) channels located on spines depends on the channel subunit composition, the activity of kinases and phosphatases, the local membrane potential and past patterns of activity. Furthermore, sources of spine Ca(2+) interact nonlinearly such that activation of one Ca(2+) channel can enhance or depress the activity of others. These studies have revealed that each spine is a complex and partitioned Ca(2+) signaling domain capable of autonomously regulating the electrical and biochemical consequences of synaptic activity.

[Indexed for MEDLINE]

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