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J Neurophysiol. 2007 Apr;97(4):2802-11. Epub 2007 Jan 24.

Contextual interaction of GABAergic circuitry with dynamic synapses.

Author information

1
Department of Physics, Washington University, St. Louis, MO 63130, USA.

Abstract

Visual context shapes human perception, yet our understanding of this phenomenon in terms of synaptic circuitry is still rudimentary. Our in vitro experiments with avian tectum reveal two distinct GABAergic pathways that mediate the spatiotemporal tectal interaction of retinal inputs. One pathway mediates postsynaptic lateral inhibition. The other pathway interacts with the synaptic depression of retinotectal synapses. Simulations of an experimentally constrained model including the two pathways reproduce the observed avian tectum wide-field neuron's sensitivity to small and moving stimuli, while being insensitive to whole-field motion.

PMID:
17251366
DOI:
10.1152/jn.00918.2006
[Indexed for MEDLINE]
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