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Int J Neural Syst. 2006 Apr;16(2):79-97.

Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity.

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Integrative and Computational Neuroscience Unit (UNIC), CNRS, Gif-sur-Yvette, France.


Spike-timing dependent plasticity (STDP) is a form of associative synaptic modification which depends on the respective timing of pre- and post-synaptic spikes. The biophysical mechanisms underlying this form of plasticity are currently not known. We present here a biophysical model which captures the characteristics of STDP, such as its frequency dependency, and the effects of spike pair or spike triplet interactions. We also make links with other well-known plasticity rules. A simplified phenomenological model is also derived, which should be useful for fast numerical simulation and analytical investigation of the impact of STDP at the network level.

[Indexed for MEDLINE]

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