Ringing changes to the 'bell-shaped curve'

Curr Biol. 1999 Dec 2;9(23):R876-8. doi: 10.1016/s0960-9822(00)80072-x.

Abstract

The 'bell-shaped' curve relating cytosolic Ca(2+) concentration to IP(3) receptor activation is considered important in the generation of the complex Ca(2+) signals seen inside many cells. But recent findings suggest this bimodal relationship is not always evident and may not apply to some IP(3) receptor isoforms.

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium / pharmacology
  • Calcium Channels / chemistry
  • Calcium Channels / metabolism*
  • Calcium Signaling / physiology*
  • Cytosol / metabolism*
  • Inositol 1,4,5-Trisphosphate / metabolism
  • Inositol 1,4,5-Trisphosphate Receptors
  • Protein Isoforms / antagonists & inhibitors
  • Protein Isoforms / metabolism
  • Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors
  • Receptors, Cytoplasmic and Nuclear / chemistry
  • Receptors, Cytoplasmic and Nuclear / metabolism*

Substances

  • Calcium Channels
  • Inositol 1,4,5-Trisphosphate Receptors
  • Protein Isoforms
  • Receptors, Cytoplasmic and Nuclear
  • Inositol 1,4,5-Trisphosphate
  • Calcium