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Brain Res. 1993 Oct 1;623(2):195-200.

Activation and modulation of calcium-activated non-selective cation channels from embryonic chick sensory neurons.

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Department of Physiology, University of New Mexico, Albuquerque 87131.


We have shown that calcium-activated non-selective (CAN) channels from embryonic chick sensory neurons are permeable to both Na+ and K+ and are not blocked by TTX, TEA, or 4-AP. These neuronal CAN channels are activated by sub-micromolar cytoplasmic Ca2+ with negative cooperativity. The effect of Ca2+ is to decrease the closed times of the channel with little effect on the time the channel remains open. Isolated neuronal CAN channels can be phosphorylated by cAMP-dependent protein kinase (PKA). The effect of phosphorylation is to shorten channel open time and to minimize the effect of Ca2+ on channel closed time.

[Indexed for MEDLINE]

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