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Neuron. 2006 Apr 20;50(2):291-307.

Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons.

Author information

1
Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA. aloson@lsuhsc.edu

Abstract

Although radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons, little is known about their integrative properties. We have used multisite two-photon glutamate uncaging to deliver different spatiotemporal input patterns to single branches while simultaneously recording the uncaging-evoked excitatory postsynaptic potentials and local Ca2+ signals. Asynchronous input patterns sum linearly in spite of the spatial clustering and produce Ca2+ signals that are mediated by NMDA receptors (NMDARs). Appropriately timed and sized input patterns ( approximately 20 inputs within approximately 6 ms) produce a supralinear summation due to the initiation of a dendritic spike. The Ca2+ signals associated with synchronous input were larger and mediated by influx through both NMDARs and voltage-gated Ca2+ channels (VGCCs). The oblique spike is a fast Na+ spike whose duration is shaped by the coincident activation of NMDAR, VGCCs, and transient K+ currents. Our results suggest that individual branches can function as single integrative compartments.

PMID:
16630839
DOI:
10.1016/j.neuron.2006.03.016
[Indexed for MEDLINE]
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