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Items: 1 to 20 of 35


Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.

Krishnamoorthy J, Tenkerian C, Gupta J, Ghaddar N, Wang S, Darini C, Staschke KA, Ghosh A, Gandin V, Topisirovic I, Kristof AS, Hatzoglou M, Simos G, Koromilas AE.

Cell Death Dis. 2018 Feb 15;9(3):254. doi: 10.1038/s41419-018-0326-2.


Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis.

Julian LM, Delaney SP, Wang Y, Goldberg AA, Doré C, Yockell-Lelièvre J, Tam RY, Giannikou K, McMurray F, Shoichet MS, Harper ME, Henske EP, Kwiatkowski DJ, Darling TN, Moss J, Kristof AS, Stanford WL.

Cancer Res. 2017 Oct 15;77(20):5491-5502. doi: 10.1158/0008-5472.CAN-17-0925. Epub 2017 Aug 22.


An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases.

Kristof AS, Petrof BJ, Hamid Q, Kolb M, Landry JS, MacKenzie A, McCormack FX, Murawski IJ, Moss J, Rauch F, Rosas IO, Shapiro AJ, Smith BM, Thomas DY, Trapnell BC, Young LR, Zariwala MA; ATS Assembly on Respiratory Cell and Molecular Biology.

Ann Am Thorac Soc. 2017 Aug;14(8):1239-1247. doi: 10.1513/AnnalsATS.201705-406WS.


Protein Delivery in the Intensive Care Unit: Optimal or Suboptimal?

Heyland DK, Weijs PJ, Coss-Bu JA, Taylor B, Kristof AS, O'Keefe GE, Martindale RG.

Nutr Clin Pract. 2017 Apr;32(1_suppl):58S-71S. doi: 10.1177/0884533617691245. Epub 2017 Mar 1.


Regulation of ULK1 Expression and Autophagy by STAT1.

Goldberg AA, Nkengfac B, Sanchez AM, Moroz N, Qureshi ST, Koromilas AE, Wang S, Burelle Y, Hussain SN, Kristof AS.

J Biol Chem. 2017 Feb 3;292(5):1899-1909. doi: 10.1074/jbc.M116.771584. Epub 2016 Dec 23.


Hyperinsulinemic-normoglycemic clamp administered together with amino acids induces anabolism after cardiac surgery.

Codère-Maruyama T, Schricker T, Shum-Tim D, Wykes L, Nitschmann E, Guichon C, Kristof AS, Hatzakorzian R.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1085-R1092. doi: 10.1152/ajpregu.00334.2016. Epub 2016 Oct 5.


Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2.

Goldberg AA, Joung KB, Mansuri A, Kang Y, Echavarria R, Nikolajev L, Sun Y, Yu JJ, Laporte SA, Schwertani A, Kristof AS.

Oncotarget. 2016 Sep 20;7(38):61152-61165. doi: 10.18632/oncotarget.10748.


mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress.

Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE.

Mol Cancer Res. 2015 Oct;13(10):1377-88. doi: 10.1158/1541-7786.MCR-15-0184-T. Epub 2015 Jun 30.


Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins.

Jaberi A, Hooker E, Guillemette J, Papillon J, Kristof AS, Cybulsky AV.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2539-52. doi: 10.1016/j.bbamcr.2015.06.005. Epub 2015 Jun 18.


Lymphangioleiomyomatosis and Tuberous Sclerosis Complex in Quebec: Prevalence and Health-care Utilization.

Kristof AS, Zhi Li P, Major P, Landry JS.

Chest. 2015 Aug;148(2):444-449. doi: 10.1378/chest.14-3095.


Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection.

Tzelepis F, Verway M, Daoud J, Gillard J, Hassani-Ardakani K, Dunn J, Downey J, Gentile ME, Jaworska J, Sanchez AM, Nédélec Y, Vali H, Tabrizian M, Kristof AS, King IL, Barreiro LB, Divangahi M.

J Clin Invest. 2015 Feb;125(2):752-68. doi: 10.1172/JCI77014. Epub 2014 Dec 22.


Reactive oxygen species regulation of autophagy in skeletal muscles.

Rahman M, Mofarrahi M, Kristof AS, Nkengfac B, Harel S, Hussain SN.

Antioxid Redox Signal. 2014 Jan 20;20(3):443-59. doi: 10.1089/ars.2013.5410.


Suspected ventilator-associated respiratory infection in severely ill patients: a prospective observational study.

Shahin J, Bielinski M, Guichon C, Flemming C, Kristof AS.

Crit Care. 2013 Oct 22;17(5):R251. doi: 10.1186/cc13077.


Pharmacokinetics of posaconazole within epithelial cells and fungi: insights into potential mechanisms of action during treatment and prophylaxis.

Campoli P, Perlin DS, Kristof AS, White TC, Filler SG, Sheppard DC.

J Infect Dis. 2013 Nov 15;208(10):1717-28. doi: 10.1093/infdis/jit358. Epub 2013 Aug 1.


Paradoxical effects of rapamycin on experimental house dust mite-induced asthma.

Fredriksson K, Fielhaber JA, Lam JK, Yao X, Meyer KS, Keeran KJ, Zywicke GJ, Qu X, Yu ZX, Moss J, Kristof AS, Levine SJ.

PLoS One. 2012;7(5):e33984. doi: 10.1371/journal.pone.0033984. Epub 2012 May 25.


Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis.

Fielhaber JA, Carroll SF, Dydensborg AB, Shourian M, Triantafillopoulos A, Harel S, Hussain SN, Bouchard M, Qureshi ST, Kristof AS.

J Immunol. 2012 May 1;188(9):4535-42. doi: 10.4049/jimmunol.1003655. Epub 2012 Mar 26.


Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.

Fielhaber JA, Tan J, Joung KB, Attias O, Huegel S, Bader M, Roux PP, Kristof AS.

J Biol Chem. 2012 Apr 27;287(18):14325-35. doi: 10.1074/jbc.M111.246785. Epub 2012 Mar 6.


Concentration of antifungal agents within host cell membranes: a new paradigm governing the efficacy of prophylaxis.

Campoli P, Al Abdallah Q, Robitaille R, Solis NV, Fielhaber JA, Kristof AS, Laverdiere M, Filler SG, Sheppard DC.

Antimicrob Agents Chemother. 2011 Dec;55(12):5732-9. doi: 10.1128/AAC.00637-11. Epub 2011 Sep 19.


Activity of the Ste20-like kinase, SLK, is enhanced by homodimerization.

Delarosa S, Guillemette J, Papillon J, Han YS, Kristof AS, Cybulsky AV.

Am J Physiol Renal Physiol. 2011 Sep;301(3):F554-64. doi: 10.1152/ajprenal.00062.2011. Epub 2011 Jun 15.


Protein expression of urotensin II, urotensin-related peptide and their receptor in the lungs of patients with lymphangioleiomyomatosis.

Kristof AS, You Z, Han YS, Giaid A.

Peptides. 2010 Aug;31(8):1511-6. doi: 10.1016/j.peptides.2010.04.017. Epub 2010 Apr 28.

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