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Items: 1 to 20 of 29


The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth.

Chaaban S, Jariwala S, Hsu CT, Redemann S, Kollman JM, Müller-Reichert T, Sept D, Bui KH, Brouhard GJ.

Dev Cell. 2018 Oct 22;47(2):191-204.e8. doi: 10.1016/j.devcel.2018.08.023. Epub 2018 Sep 20.


Microtubule dynamics: an interplay of biochemistry and mechanics.

Brouhard GJ, Rice LM.

Nat Rev Mol Cell Biol. 2018 Jul;19(7):451-463. doi: 10.1038/s41580-018-0009-y. Review.


A microtubule bestiary: structural diversity in tubulin polymers.

Chaaban S, Brouhard GJ.

Mol Biol Cell. 2017 Nov 1;28(22):2924-2931. doi: 10.1091/mbc.E16-05-0271. Review.


GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK.

Bendre S, Rondelet A, Hall C, Schmidt N, Lin YC, Brouhard GJ, Bird AW.

J Cell Biol. 2016 Dec 5;215(5):631-647. Epub 2016 Nov 23.


The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.

Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A.

Sci Transl Med. 2016 Nov 16;8(365):365ra159. Erratum in: Sci Transl Med. 2017 Dec 20;9(421):.


Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development.

Kowanda M, Bergalet J, Wieczorek M, Brouhard G, Lécuyer É, Lasko P.

Biol Open. 2016 Aug 15;5(8):1040-51. doi: 10.1242/bio.019638.


Microtubule-associated proteins control the kinetics of microtubule nucleation.

Wieczorek M, Bechstedt S, Chaaban S, Brouhard GJ.

Nat Cell Biol. 2015 Jul;17(7):907-16. doi: 10.1038/ncb3188. Epub 2015 Jun 22.


Dynamic instability 30 years later: complexities in microtubule growth and catastrophe.

Brouhard GJ.

Mol Biol Cell. 2015 Apr 1;26(7):1207-10. doi: 10.1091/mbc.E13-10-0594. Review.


The contribution of αβ-tubulin curvature to microtubule dynamics.

Brouhard GJ, Rice LM.

J Cell Biol. 2014 Nov 10;207(3):323-34. doi: 10.1083/jcb.201407095. Review.


Doublecortin recognizes the longitudinal curvature of the microtubule end and lattice.

Bechstedt S, Lu K, Brouhard GJ.

Curr Biol. 2014 Oct 20;24(20):2366-75. doi: 10.1016/j.cub.2014.08.039. Epub 2014 Oct 2.


Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton.

Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, Cloutier JF, Fournier AE.

J Biol Chem. 2014 Oct 24;289(43):30133-43. doi: 10.1074/jbc.M114.570440. Epub 2014 Sep 15.


Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality.

Noujaim M, Bechstedt S, Wieczorek M, Brouhard GJ.

PLoS One. 2014 Feb 3;9(2):e86786. doi: 10.1371/journal.pone.0086786. eCollection 2014.


Fluorescence-based assays for microtubule architecture.

Bechstedt S, Brouhard GJ.

Methods Cell Biol. 2013;115:343-54. doi: 10.1016/B978-0-12-407757-7.00021-9.


Measuring ligand-receptor binding kinetics and dynamics using k-space image correlation spectroscopy.

Brandão HB, Sangji H, Pandžić E, Bechstedt S, Brouhard GJ, Wiseman PW.

Methods. 2014 Mar 15;66(2):273-82. doi: 10.1016/j.ymeth.2013.07.042. Epub 2013 Aug 9.


Motors and MAPs collaborate to size up microtubules.

Bechstedt S, Brouhard GJ.

Dev Cell. 2013 Jul 29;26(2):118-20. doi: 10.1016/j.devcel.2013.07.010.


Polymicrogyria with dysmorphic basal ganglia? Think tubulin!

Amrom D, Tanyalçin I, Verhelst H, Deconinck N, Brouhard GJ, Décarie JC, Vanderhasselt T, Das S, Hamdan FF, Lissens W, Michaud JL, Jansen AC.

Clin Genet. 2014 Feb;85(2):178-83. doi: 10.1111/cge.12141. Epub 2013 Apr 24.


Microtubules: sizing up the GTP cap.

Brouhard G, Sept D.

Curr Biol. 2012 Sep 25;22(18):R802-3. doi: 10.1016/j.cub.2012.07.050.


Doublecortin recognizes the 13-protofilament microtubule cooperatively and tracks microtubule ends.

Bechstedt S, Brouhard GJ.

Dev Cell. 2012 Jul 17;23(1):181-92. doi: 10.1016/j.devcel.2012.05.006. Epub 2012 Jun 21.


Variations on the single-molecule assay for microtubule-associated proteins and kinesins.

Bechstedt S, Wieczorek M, Noujaim M, Brouhard GJ.

Methods Mol Biol. 2011;777:167-76. doi: 10.1007/978-1-61779-252-6_12.


XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region.

Widlund PO, Stear JH, Pozniakovsky A, Zanic M, Reber S, Brouhard GJ, Hyman AA, Howard J.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2741-6. doi: 10.1073/pnas.1016498108. Epub 2011 Jan 31.

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