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Items: 155

1.

Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein.

Li HY, Liu XL, Liu YT, Jia ZK, Filep JG, Potempa LA, Ji SR, Wu Y.

Cardiovasc Res. 2018 Jul 9. doi: 10.1093/cvr/cvy181. [Epub ahead of print]

PMID:
29992240
2.

Targeting formyl peptide receptors to facilitate the resolution of inflammation.

Filep JG, Sekheri M, El Kebir D.

Eur J Pharmacol. 2018 Aug 15;833:339-348. doi: 10.1016/j.ejphar.2018.06.025. Epub 2018 Jun 20. Review.

PMID:
29935171
3.

Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice.

Zhao S, Ghosh A, Lo CS, Chenier I, Scholey JW, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD.

Endocrinology. 2018 Feb 1;159(2):836-852. doi: 10.1210/en.2017-00752.

PMID:
29211853
4.

Mild acidosis delays neutrophil apoptosis via multiple signaling pathways and acts in concert with inflammatory mediators.

El Kebir D, de Oliveira Lima Dos Santos E, Mansouri S, Sekheri M, Filep JG.

J Leukoc Biol. 2017 Dec;102(6):1389-1400. doi: 10.1189/jlb.3A0117-041R. Epub 2017 Sep 19.

PMID:
28928268
5.

Context-dependent signalling in platelets in vascular diseases: ROCK2 around thrombosis.

Filep JG.

Cardiovasc Res. 2017 Sep 1;113(11):1267-1269. doi: 10.1093/cvr/cvx141. No abstract available.

6.

A Haptotaxis Assay for Neutrophils using Optical Patterning and a High-content Approach.

Roy J, Mazzaferri J, Filep JG, Costantino S.

Sci Rep. 2017 Jun 6;7(1):2869. doi: 10.1038/s41598-017-02993-6.

7.

Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice.

Lo CS, Shi Y, Chenier I, Ghosh A, Wu CH, Cailhier JF, Ethier J, Lattouf JB, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD.

Diabetes. 2017 Jul;66(7):1964-1978. doi: 10.2337/db16-1588. Epub 2017 Apr 19.

8.

Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.

Ghosh A, Abdo S, Zhao S, Wu CH, Shi Y, Lo CS, Chenier I, Alquier T, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD.

Endocrinology. 2017 Apr 1;158(4):903-919. doi: 10.1210/en.2016-1576.

9.

Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism.

Hernandez-Anzaldo S, Brglez V, Hemmeryckx B, Leung D, Filep JG, Vance JE, Vance DE, Kassiri Z, Lijnen RH, Lambeau G, Fernandez-Patron C.

J Am Heart Assoc. 2016 Sep 30;5(10). pii: e004228.

10.

Attenuation of Lung Ischemia-Reperfusion Injury: Silencing the Fas Gene.

Filep JG.

Crit Care Med. 2016 Aug;44(8):1619-20. doi: 10.1097/CCM.0000000000001687. No abstract available.

PMID:
27428128
11.

Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.

Hernandez-Anzaldo S, Berry E, Brglez V, Leung D, Yun TJ, Lee JS, Filep JG, Kassiri Z, Cheong C, Lambeau G, Lehner R, Fernandez-Patron C.

J Am Heart Assoc. 2015 Nov 13;4(11). pii: e002553. doi: 10.1161/JAHA.115.002553.

12.

Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-β1-induced kidney injury in a mouse model of diabetes.

Lo CS, Shi Y, Chang SY, Abdo S, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Diabetologia. 2015 Oct;58(10):2443-54. doi: 10.1007/s00125-015-3700-y. Epub 2015 Aug 1.

13.

C-reactive protein and inflammation: conformational changes affect function.

Wu Y, Potempa LA, El Kebir D, Filep JG.

Biol Chem. 2015 Nov;396(11):1181-97. doi: 10.1515/hsz-2015-0149. Review.

PMID:
26040008
14.

Toll-like receptor 9 signaling regulates tissue factor and tissue factor pathway inhibitor expression in human endothelial cells and coagulation in mice.

El Kebir D, Damlaj A, Makhezer N, Filep JG.

Crit Care Med. 2015 Jun;43(6):e179-89. doi: 10.1097/CCM.0000000000001005.

15.
16.

Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice.

Shi Y, Lo CS, Padda R, Abdo S, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Clin Sci (Lond). 2015 May 1;128(10):649-63. doi: 10.1042/CS20140329.

PMID:
25495544
17.

Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice.

Abdo S, Shi Y, Otoukesh A, Ghosh A, Lo CS, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Diabetes. 2014 Oct;63(10):3483-96. doi: 10.2337/db13-1830. Epub 2014 May 8.

18.

Purinergic receptors and atherosclerosis: emerging role for vessel wall P2Y12.

Rauch BH, Filep JG.

Cardiovasc Res. 2014 Jun 1;102(3):339-41. doi: 10.1093/cvr/cvu108. Epub 2014 Apr 22. No abstract available.

PMID:
24760550
19.

Topological localization of monomeric C-reactive protein determines proinflammatory endothelial cell responses.

Li HY, Wang J, Wu YX, Zhang L, Liu ZP, Filep JG, Potempa LA, Wu Y, Ji SR.

J Biol Chem. 2014 May 16;289(20):14283-90. doi: 10.1074/jbc.M114.555318. Epub 2014 Apr 7.

20.

Toll-like receptor 9 signaling delays neutrophil apoptosis by increasing transcription of Mcl-1.

El Kebir D, Damlaj A, Filep JG.

PLoS One. 2014 Jan 22;9(1):e87006. doi: 10.1371/journal.pone.0087006. eCollection 2014.

21.

Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution.

Filep JG.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18033-4. doi: 10.1073/pnas.1317798110. Epub 2013 Oct 23. No abstract available.

22.

Glucocorticoid protection against myocardial ischemia-reperfusion injury: central role for the PGD2-Nrf2 pathway.

Filep JG.

Hypertension. 2014 Jan;63(1):22-3. doi: 10.1161/HYPERTENSIONAHA.113.01832. Epub 2013 Oct 7. No abstract available.

PMID:
24101660
23.

Resolution of inflammation: leukocytes and molecular pathways as potential therapeutic targets.

Filep JG.

Front Immunol. 2013 Aug 27;4:256. doi: 10.3389/fimmu.2013.00256. eCollection 2013. No abstract available.

24.

Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice.

Abdo S, Lo CS, Chenier I, Shamsuyarova A, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Diabetologia. 2013 Jul;56(7):1649-60. doi: 10.1007/s00125-013-2910-4. Epub 2013 Apr 23.

PMID:
23609310
25.

Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice.

Shi Y, Lo CS, Chenier I, Maachi H, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Am J Physiol Renal Physiol. 2013 Jun 1;304(11):F1335-46. doi: 10.1152/ajprenal.00405.2012. Epub 2013 Apr 3.

26.

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins.

El Kebir D, Filep JG.

Front Immunol. 2013 Mar 6;4:60. doi: 10.3389/fimmu.2013.00060. eCollection 2013.

27.

Resolution pathways in inflammation: the devil in the adipose tissues and in the details. Focus on "Diversity of lipid mediators in human adipose tissue depots".

Filep JG.

Am J Physiol Cell Physiol. 2013 Jun 15;304(12):C1127-8. doi: 10.1152/ajpcell.00063.2013. Epub 2013 Mar 6. No abstract available.

28.

Myeloid nuclear differentiation antigen, neutrophil apoptosis and sepsis.

Milot E, Fotouhi-Ardakani N, Filep JG.

Front Immunol. 2012 Dec 27;3:397. doi: 10.3389/fimmu.2012.00397. eCollection 2012.

29.

Targeting neutrophil apoptosis for enhancing the resolution of inflammation.

El Kebir D, Filep JG.

Cells. 2013 May 22;2(2):330-48. doi: 10.3390/cells2020330.

30.

GPCRs in cardiovascular pathologies.

Fernandez-Patron C, Filep JG.

Drug Discov Today Dis Mech. 2012 Fall;9(3):e75-e78. No abstract available.

31.

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation.

El Kebir D, Gjorstrup P, Filep JG.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14983-8. doi: 10.1073/pnas.1206641109. Epub 2012 Aug 27.

32.

Impaired neutrophil migration during sepsis: paying the toll.

Filep JG.

Crit Care Med. 2012 Sep;40(9):2721-2. doi: 10.1097/CCM.0b013e31825bc852. No abstract available.

PMID:
22903100
33.

Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice.

Lo CS, Chang SY, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Diabetes. 2012 Oct;61(10):2597-608. Epub 2012 Jun 4.

34.

Bcl-2-modifying factor induces renal proximal tubular cell apoptosis in diabetic mice.

Lau GJ, Godin N, Maachi H, Lo CS, Wu SJ, Zhu JX, Brezniceanu ML, Chénier I, Fragasso-Marquis J, Lattouf JB, Ethier J, Filep JG, Ingelfinger JR, Nair V, Kretzler M, Cohen CD, Zhang SL, Chan JS.

Diabetes. 2012 Feb;61(2):474-84. doi: 10.2337/db11-0141. Epub 2011 Dec 30.

35.

Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice.

Lo CS, Liu F, Shi Y, Maachi H, Chenier I, Godin N, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F840-52. doi: 10.1152/ajprenal.00340.2011. Epub 2011 Dec 28.

36.

Regulation of neutrophil survival/apoptosis by Mcl-1.

Milot E, Filep JG.

ScientificWorldJournal. 2011;11:1948-62. doi: 10.1100/2011/131539. Epub 2011 Oct 26. Review.

37.

C-reactive protein-derived peptide 201-206 inhibits neutrophil adhesion to endothelial cells and platelets through CD32.

El Kebir D, Zhang Y, Potempa LA, Wu Y, Fournier A, Filep JG.

J Leukoc Biol. 2011 Dec;90(6):1167-75. doi: 10.1189/jlb.0111032. Epub 2011 Sep 20.

PMID:
21934067
38.

A redox switch in C-reactive protein modulates activation of endothelial cells.

Wang MY, Ji SR, Bai CJ, El Kebir D, Li HY, Shi JM, Zhu W, Costantino S, Zhou HH, Potempa LA, Zhao J, Filep JG, Wu Y.

FASEB J. 2011 Sep;25(9):3186-96. doi: 10.1096/fj.11-182741. Epub 2011 Jun 13.

PMID:
21670067
39.

Role of neutrophil apoptosis in the resolution of inflammation.

El Kebir D, Filep JG.

ScientificWorldJournal. 2010 Sep 1;10:1731-48. doi: 10.1100/tsw.2010.169. Review.

40.

Role for myeloid nuclear differentiation antigen in the regulation of neutrophil apoptosis during sepsis.

Fotouhi-Ardakani N, Kebir DE, Pierre-Charles N, Wang L, Ahern SP, Filep JG, Milot E.

Am J Respir Crit Care Med. 2010 Aug 1;182(3):341-50. doi: 10.1164/rccm.201001-0075OC. Epub 2010 Apr 15.

PMID:
20395555
41.

Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy.

Brezniceanu ML, Lau CJ, Godin N, Chénier I, Duclos A, Ethier J, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

J Am Soc Nephrol. 2010 Jun;21(6):943-54. doi: 10.1681/ASN.2009030242. Epub 2010 Mar 18.

42.

Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice.

Godin N, Liu F, Lau GJ, Brezniceanu ML, Chénier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Kidney Int. 2010 Jun;77(12):1086-97. doi: 10.1038/ki.2010.63. Epub 2010 Mar 17.

44.

Lipid mediator interplay: resolvin D1 attenuates inflammation evoked by glutathione-conjugated lipid peroxidation products.

Filep JG.

Br J Pharmacol. 2009 Oct;158(4):1059-61. doi: 10.1111/j.1476-5381.2009.00235.x.

45.

Serum amyloid A as a marker and mediator of acute coronary syndromes.

Filep JG, El Kebir D.

Future Cardiol. 2008 Sep;4(5):495-504. doi: 10.2217/14796678.4.5.495.

PMID:
19804343
46.

Neutrophil apoptosis: a target for enhancing the resolution of inflammation.

Filep JG, El Kebir D.

J Cell Biochem. 2009 Dec 1;108(5):1039-46. doi: 10.1002/jcb.22351. Review.

PMID:
19760640
47.

Monomeric C-reactive protein decreases acetylated LDL uptake in human endothelial cells.

Schwedler SB, Hansen-Hagge T, Reichert M, Schmiedeke D, Schneider R, Galle J, Potempa LA, Wanner C, Filep JG.

Clin Chem. 2009 Sep;55(9):1728-31. doi: 10.1373/clinchem.2009.125732. Epub 2009 Jul 17.

48.

Platelets affect the structure and function of C-reactive protein.

Filep JG.

Circ Res. 2009 Jul 17;105(2):109-11. doi: 10.1161/CIRCRESAHA.109.202010. No abstract available.

PMID:
19608987
49.

15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury.

El Kebir D, József L, Pan W, Wang L, Petasis NA, Serhan CN, Filep JG.

Am J Respir Crit Care Med. 2009 Aug 15;180(4):311-9. doi: 10.1164/rccm.200810-1601OC. Epub 2009 May 29.

50.

Bacterial DNA activates endothelial cells and promotes neutrophil adherence through TLR9 signaling.

El Kebir D, József L, Pan W, Wang L, Filep JG.

J Immunol. 2009 Apr 1;182(7):4386-94. doi: 10.4049/jimmunol.0803044.

51.

Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft microdomains.

Ji SR, Ma L, Bai CJ, Shi JM, Li HY, Potempa LA, Filep JG, Zhao J, Wu Y.

FASEB J. 2009 Jun;23(6):1806-16. doi: 10.1096/fj.08-116962. Epub 2009 Jan 9.

PMID:
19136614
52.

Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension.

Liu F, Wei CC, Wu SJ, Chenier I, Zhang SL, Filep JG, Ingelfinger JR, Chan JS.

Kidney Int. 2009 Jan;75(2):156-66. doi: 10.1038/ki.2008.509. Epub 2008 Oct 15.

53.

Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation.

El Kebir D, József L, Pan W, Filep JG.

Circ Res. 2008 Aug 15;103(4):352-9. doi: 10.1161/01.RES.0000326772.76822.7a. Epub 2008 Jul 10.

PMID:
18617697
54.

Opposing regulation of neutrophil apoptosis through the formyl peptide receptor-like 1/lipoxin A4 receptor: implications for resolution of inflammation.

El Kebir D, József L, Filep JG.

J Leukoc Biol. 2008 Sep;84(3):600-6. doi: 10.1189/jlb.1107765. Epub 2008 May 21. Review.

PMID:
18495783
55.

Perplexity of monocyte responses to C-reactive protein (CRP).

Filep JG.

Thromb Haemost. 2008 Mar;99(3):461-2. doi: 10.1160/TH08-02-0072. No abstract available.

PMID:
18327390
56.

Neutrophil recognition of bacterial DNA and Toll-like receptor 9-dependent and -independent regulation of neutrophil function.

El Kebir D, József L, Filep JG.

Arch Immunol Ther Exp (Warsz). 2008 Jan-Feb;56(1):41-53. doi: 10.1007/s00005-008-0008-3. Epub 2008 Feb 5. Review.

PMID:
18250968
57.

Overexpression of angiotensinogen increases tubular apoptosis in diabetes.

Liu F, Brezniceanu ML, Wei CC, Chénier I, Sachetelli S, Zhang SL, Filep JG, Ingelfinger JR, Chan JS.

J Am Soc Nephrol. 2008 Feb;19(2):269-80. Epub 2007 Dec 5.

58.

Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells.

Brezniceanu ML, Liu F, Wei CC, Chénier I, Godin N, Zhang SL, Filep JG, Ingelfinger JR, Chan JS.

Diabetes. 2008 Feb;57(2):451-9. Epub 2007 Oct 31.

59.

Conduct unbecoming: C-reactive protein interactions with a broad range of protein molecules.

Boguslawski G, McGlynn PW, Potempa LA, Filep JG, Labarrere CA.

J Heart Lung Transplant. 2007 Jul;26(7):705-13.

PMID:
17613401
60.

Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation.

El Kebir D, József L, Khreiss T, Pan W, Petasis NA, Serhan CN, Filep JG.

J Immunol. 2007 Jul 1;179(1):616-22.

61.
62.
63.

Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice.

Brezniceanu ML, Liu F, Wei CC, Tran S, Sachetelli S, Zhang SL, Guo DF, Filep JG, Ingelfinger JR, Chan JS.

Kidney Int. 2007 May;71(9):912-23. Epub 2007 Mar 7.

64.
65.

Transforming growth factor-beta 1 stimulates angiotensinogen gene expression in kidney proximal tubular cells.

Brezniceanu ML, Wei CC, Zhang SL, Hsieh TJ, Guo DF, Hébert MJ, Ingelfinger JR, Filep JG, Chan JS.

Kidney Int. 2006 Jun;69(11):1977-85.

66.

RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney.

Sachetelli S, Liu Q, Zhang SL, Liu F, Hsieh TJ, Brezniceanu ML, Guo DF, Filep JG, Ingelfinger JR, Sigmund CD, Hamet P, Chan JS.

Kidney Int. 2006 Mar;69(6):1016-23.

67.

C-reactive protein: a family of proteins to regulate cardiovascular function.

Schwedler SB, Filep JG, Galle J, Wanner C, Potempa LA.

Am J Kidney Dis. 2006 Feb;47(2):212-22. Review.

PMID:
16431250
68.

Endocan or endothelial cell-specific molecule-1: a novel prognostic marker of sepsis?

Filep JG.

Crit Care Med. 2006 Feb;34(2):574-5. No abstract available.

PMID:
16424758
69.

Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils.

József L, Khreiss T, El Kebir D, Filep JG.

J Immunol. 2006 Jan 15;176(2):1195-202.

70.

Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils.

Khreiss T, József L, Potempa LA, Filep JG.

Circ Res. 2005 Sep 30;97(7):690-7. Epub 2005 Aug 25.

PMID:
16123332
71.

Lipoxins and aspirin-triggered lipoxins in neutrophil adhesion and signal transduction.

Filep JG, Khreiss T, József L.

Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct;73(3-4):257-62. Review.

PMID:
15979865
72.

Sepsis and vascular dysfunction: connections with endothelial connexin 40.

Filep JG.

Crit Care Med. 2005 Jun;33(6):1442-3. No abstract available.

PMID:
15942380
73.

Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells.

Hsieh TJ, Fustier P, Wei CC, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Fantus IG, Hamet P, Chan JS.

J Endocrinol. 2004 Dec;183(3):535-50.

PMID:
15590980
74.

Opposing effects of C-reactive protein isoforms on shear-induced neutrophil-platelet adhesion and neutrophil aggregation in whole blood.

Khreiss T, József L, Potempa LA, Filep JG.

Circulation. 2004 Oct 26;110(17):2713-20. Epub 2004 Oct 18.

PMID:
15492312
75.

CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes.

József L, Khreiss T, Filep JG.

FASEB J. 2004 Nov;18(14):1776-8. Epub 2004 Sep 2.

PMID:
15345690
76.
77.

Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells.

Khreiss T, József L, Potempa LA, Filep JG.

Circulation. 2004 Apr 27;109(16):2016-22. Epub 2004 Mar 29.

PMID:
15051635
78.

Apoptosis of endothelial cells triggers a caspase-dependent anti-apoptotic paracrine loop active on VSMC.

Raymond MA, Désormeaux A, Laplante P, Vigneault N, Filep JG, Landry K, Pshezhetsky AV, Hébert MJ.

FASEB J. 2004 Apr;18(6):705-7. Epub 2004 Feb 20.

PMID:
14977881
79.
81.

High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells.

Hsieh TJ, Fustier P, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Fantus IG, Hamet P, Chan JS.

Endocrinology. 2003 Oct;144(10):4338-49. Epub 2003 Jul 10.

PMID:
12960040
82.

Platelet activating factor receptors.

Marrache AM, Gobeil F Jr, Bernier SG, Stankova J, Rola-Pleszczynski M, Choufani S, Bkaily G, Bourdeau A, Sirois MG, Vazquez-Tello A, Fan L, Joyal JS, Filep JG, Varma DR, Ribeiro-Da-silva A, Chemtob S.

Adv Exp Med Biol. 2003;525:161-4. No abstract available.

PMID:
12751758
83.

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion.

Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CN.

Adv Exp Med Biol. 2002;507:223-8. Review. No abstract available.

PMID:
12664589
84.

Blockade of the apoptotic machinery by cyclosporin A redirects cell death toward necrosis in arterial endothelial cells: regulation by reactive oxygen species and cathepsin D.

Raymond MA, Mollica L, Vigneault N, Désormeaux A, Chan JS, Filep JG, Hébert MJ.

FASEB J. 2003 Mar;17(3):515-7. Epub 2003 Jan 2.

PMID:
12514115
85.

Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose.

Zhang SL, Chen X, Wei CC, Filep JG, Tang SS, Ingelfinger JR, Chan JS.

Endocrinology. 2002 Dec;143(12):4627-35.

PMID:
12446590
86.

Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor.

Marrache AM, Gobeil F Jr, Bernier SG, Stankova J, Rola-Pleszczynski M, Choufani S, Bkaily G, Bourdeau A, Sirois MG, Vazquez-Tello A, Fan L, Joyal JS, Filep JG, Varma DR, Ribeiro-Da-Silva A, Chemtob S.

J Immunol. 2002 Dec 1;169(11):6474-81.

87.

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.

József L, Zouki C, Petasis NA, Serhan CN, Filep JG.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13266-71. Epub 2002 Sep 16.

88.

Loss of pentameric symmetry of C-reactive protein is associated with delayed apoptosis of human neutrophils.

Khreiss T, József L, Hossain S, Chan JS, Potempa LA, Filep JG.

J Biol Chem. 2002 Oct 25;277(43):40775-81. Epub 2002 Aug 26.

89.

High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells.

Hsieh TJ, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Chan JS.

Endocrinology. 2002 Aug;143(8):2975-85.

PMID:
12130563
90.

Molecular mechanism(s) of insulin action on the expression of the angiotensinogen gene in kidney proximal tubular cells.

Wu XH, Chen X, Zhang SL, Pang L, To C, Wang TT, Hohman TC, Filep JG, Chan JS.

J Renin Angiotensin Aldosterone Syst. 2000 Jun;1(2):166-74.

PMID:
11967809
91.
92.

Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells.

S-L Zhang, Chen X, Hsieh TJ, Leclerc M, Henley N, Allidina A, Hallé JP, Brunette MG, Filep JG, Tang SS, Ingelfinger JR, Chan JS.

J Endocrinol. 2002 Feb;172(2):333-44.

PMID:
11834451
94.
95.

Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil-endothelial cell adhesion.

Zouki C, Haas B, Chan JS, Potempa LA, Filep JG.

J Immunol. 2001 Nov 1;167(9):5355-61.

96.

Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32].

Fernandez-Patron C, Zouki C, Whittal R, Chan JS, Davidge ST, Filep JG.

FASEB J. 2001 Oct;15(12):2230-40.

PMID:
11641250
97.

Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes.

Zouki C, József L, Ouellet S, Paquette Y, Filep JG.

J Leukoc Biol. 2001 May;69(5):815-24.

PMID:
11358991
98.

Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin.

Chen X, Zhang SL, Pang L, Filep JG, Tang SS, Ingelfinger JR, Chan JS.

Endocrinology. 2001 Jun;142(6):2577-85.

PMID:
11356707
99.

Effect of renin-angiotensin system blockade on the expression of the angiotensinogen gene and induction of hypertrophy in rat kidney proximal tubular cells.

Zhang SL, To C, Chen X, Filep JG, Tang SS, Ingelfinger JR, Carrière S, Chan JS.

Exp Nephrol. 2001 Mar-Apr;9(2):109-17.

PMID:
11150859
100.

High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.

Zhang SL, Tang SS, Chen X, Filep JG, Ingelfinger JR, Chan JS.

Endocrinology. 2000 Dec;141(12):4637-46.

PMID:
11108278
101.
106.

Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.

Zhang SL, Chen X, Filep JG, Tang SS, Ingelfinger JR, Chan JS.

Endocrinology. 1999 Nov;140(11):5285-92.

PMID:
10537159
107.
108.

Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells.

Zhang SL, Filep JG, Hohman TC, Tang SS, Ingelfinger JR, Chan JS.

Kidney Int. 1999 Feb;55(2):454-64.

109.

Peroxynitrite mediates IL-8 gene expression and production in lipopolysaccharide-stimulated human whole blood.

Filep JG, Beauchamp M, Baron C, Paquette Y.

J Immunol. 1998 Nov 15;161(10):5656-62.

110.
111.

Analysis of effects of bosentan (Ro 47-0203), a nonpeptide endothelin ETA/ETB receptor antagonist, in the hind-limb vascular bed of the cat.

Champion HC, Estrada LS, Estrada LN, Filep JG, Kadowitz PJ.

Can J Physiol Pharmacol. 1998 Feb;76(2):141-7.

PMID:
9635152
112.
114.

Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils.

Filep JG, Delalandre A, Payette Y, Földes-Filep E.

Circulation. 1997 Jul 1;96(1):295-301.

PMID:
9236448
116.

On the mechanisms of immunodominance in cytotoxic T lymphocyte responses to minor histocompatibility antigens.

Pion S, Fontaine P, Desaulniers M, Jutras J, Filep JG, Perreault C.

Eur J Immunol. 1997 Feb;27(2):421-30.

PMID:
9045913
117.
119.

Involvement of nitric oxide in target-cell lysis and DNA fragmentation induced by murine natural killer cells.

Filep JG, Baron C, Lachance S, Perreault C, Chan JS.

Blood. 1996 Jun 15;87(12):5136-43.

120.

Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat.

Filep JG, Skrobik Y, Fournier A, Földes-Filep E.

Br J Pharmacol. 1996 Jun;118(4):893-900.

121.

Plasma endothelin correlates with antiendothelial antibodies in patients with mixed connective tissue disease.

Filep JG, Bodolay E, Sipka S, Gyimesi E, Csipö I, Szegedi G.

Circulation. 1995 Nov 15;92(10):2969-74.

PMID:
7586267
122.
123.
124.

Characterization of receptors mediating vascular responses to endothelin-1 in the conscious rat.

Filep JG, Clozel M, Fournier A, Földes-Filep E.

Br J Pharmacol. 1994 Nov;113(3):845-52.

125.

Pulmonary surfactant lipids inhibit prostanoid production of guinea pig alveolar macrophages.

Földes-Filep E, Sirois P, Filep JG.

J Leukoc Biol. 1994 Oct;56(4):475-80.

PMID:
7930944
127.
128.

Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rat.

Filep JG, Földes-Filep E, Rousseau A, Sirois P, Fournier A.

Br J Pharmacol. 1993 Nov;110(3):1213-21.

129.

Relaxation by dexamethasone of isolated guinea-pig airways precontracted with endothelin-1.

Filep JG, Battistini B, Fournier A, Sirois P.

Eur J Pharmacol. 1993 Aug 24;240(2-3):315-8.

PMID:
8243548
130.

Increased plasma levels of endothelin during anaphylactic shock in the guinea-pig.

Filep JG, Télémaque S, Battistini B, Sirois P, D'Orléans-Juste P.

Eur J Pharmacol. 1993 Aug 3;239(1-3):231-6.

PMID:
8223900
131.

Enhancement by endothelin-1 of microvascular permeability via the activation of ETA receptors.

Filep JG, Sirois MG, Földes-Filep E, Rousseau A, Plante GE, Fournier A, Yano M, Sirois P.

Br J Pharmacol. 1993 Jul;109(3):880-6.

132.
133.

The in vivo antiaggregatory action of endothelin-1 is not mediated through the endothelin ETA receptor.

Hermán F, Yano M, Filep JG.

Eur J Pharmacol. 1993 May 12;236(1):143-6.

PMID:
8319738
134.

Endothelin derivatives showing potent effects in the guinea pig trachea.

Germain M, Battistini B, Filep JG, Sirois P, Fournier A.

Peptides. 1993 May-Jun;14(3):613-9.

PMID:
8332557
135.

Nitric oxide modulates vascular permeability in the rat coronary circulation.

Filep JG, Földes-Filep E, Sirois P.

Br J Pharmacol. 1993 Feb;108(2):323-6.

136.
137.
138.

Structure-activity relationship of analogues of endothelin-1: dissociation of hypotensive and pressor actions.

Filep JG, Rousseau A, Fournier A, Sirois P.

Eur J Pharmacol. 1992 Sep 22;220(2-3):263-6.

PMID:
1425997
139.

Endothelin-1 enhances vascular permeability in the rat heart through the ETA receptor.

Filep JG, Földes-Filep E, Rousseau A, Fournier A, Sirois P, Yano M.

Eur J Pharmacol. 1992 Aug 25;219(2):343-4.

PMID:
1425961
140.

Characterization of ATP-diphosphohydrolase activities in the intima and media of the bovine aorta: evidence for a regulatory role in platelet activation in vitro.

Côté YP, Filep JG, Battistini B, Gauvreau J, Sirois P, Beaudoin AR.

Biochim Biophys Acta. 1992 Jun 9;1139(1-2):133-42.

PMID:
1610912
141.

Endothelin-1 enhances vascular permeability in conscious rats: role of thromboxane A2.

Sirois MG, Filep JG, Rousseau A, Fournier A, Plante GE, Sirois P.

Eur J Pharmacol. 1992 Apr 22;214(2-3):119-25.

PMID:
1516634
142.

Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor.

Filep JG, Hermán F, Földes-Filep E, Schneider F, Braquet P.

Br J Pharmacol. 1992 Apr;105(4):912-8.

143.
144.

Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor.

Filep JG, Sirois MG, Rousseau A, Fournier A, Sirois P.

Br J Pharmacol. 1991 Dec;104(4):797-804.

146.
147.

Endothelin-1 induces prostacyclin release from bovine aortic endothelial cells.

Filep JG, Battistini B, Côté YP, Beaudoin AR, Sirois P.

Biochem Biophys Res Commun. 1991 May 31;177(1):171-6.

PMID:
2043104
148.

A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro.

Battistini B, Filep JG, Cragoe EJ Jr, Fournier A, Sirois P.

Biochem Biophys Res Commun. 1991 Mar 15;175(2):583-8.

PMID:
1850247
149.

In vivo antiaggregatory action of platelet-activating factor in beagle dogs: role for prostacyclin.

Hermán F, Magyar K, Filep JG.

Thromb Haemost. 1991 Mar 4;65(3):296-9.

PMID:
2048053
150.

C-reactive protein inhibits binding of platelet-activating factor to human platelets.

Filep JG, Hermán F, Kelemen E, Földes-Filep E.

Thromb Res. 1991 Feb 15;61(4):411-21.

PMID:
2063349
151.

Antiaggregatory and hypotensive effects of endothelin-1 in beagle dogs: role for prostacyclin.

Filep JG, Hermán F, Battistini B, Chabrier PE, Braquet P, Sirois P.

J Cardiovasc Pharmacol. 1991;17 Suppl 7:S216-8.

PMID:
1725337
152.
153.

Endothelin-1 does not affect human platelet aggregation in whole blood and platelet rich plasma.

Battistini B, Filep JG, Hermán F, Sirois P.

Thromb Res. 1990 Oct 1;60(1):105-8. No abstract available.

PMID:
2278035
154.

Endothelin-induced constriction of guinea pig airways: role of platelet-activating factor.

Battistini B, Sirois P, Braquet P, Filep JG.

Eur J Pharmacol. 1990 Sep 21;186(2-3):307-10.

PMID:
2289531
155.

Endothelin induces thromboxane release and contraction of isolated guinea-pig airways.

Filep JG, Battistini B, Sirois P.

Life Sci. 1990;47(20):1845-50.

PMID:
2147975

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