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Items: 157

1.

3-mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.

Abdollahi Govar A, Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos A, Módis K.

Br J Pharmacol. 2019 Jan 14. doi: 10.1111/bph.14574. [Epub ahead of print]

PMID:
30644090
2.

Nitroglycerin limits infarct size through S-nitrosation of Cyclophilin D: A novel mechanism for an old drug.

Bibli SI, Papapetropoulos A, Iliodromitis EK, Daiber A, Randriamboavonjy V, Steven S, Brouckaert P, Chatzianastasiou A, Kypreos KE, Hausenloy DJ, Fleming I, Andreadou I.

Cardiovasc Res. 2018 Aug 27. doi: 10.1093/cvr/cvy222. [Epub ahead of print]

PMID:
30165375
3.

Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice.

Glynos C, Bibli SI, Katsaounou P, Pavlidou A, Magkou C, Karavana V, Topouzis S, Kalomenidis I, Zakynthinos SG, Papapetropoulos A.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 9. doi: 10.1152/ajplung.00389.2017. [Epub ahead of print]

PMID:
30091379
4.

A selective and sensitive method for quantification of endogenous polysulfide production in biological samples.

Bibli SI, Luck B, Zukunft S, Wittig J, Chen W, Xian M, Papapetropoulos A, Hu J, Fleming I.

Redox Biol. 2018 Sep;18:295-304. doi: 10.1016/j.redox.2018.07.016. Epub 2018 Jul 21.

5.

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.

Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I.

Circulation. 2019 Jan 2;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757.

PMID:
29970364
6.

Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity.

Mitidieri E, Tramontano T, Gurgone D, Citi V, Calderone V, Brancaleone V, Katsouda A, Nagahara N, Papapetropoulos A, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R.

Nitric Oxide. 2018 May 1;75:53-59. doi: 10.1016/j.niox.2018.02.003. Epub 2018 Feb 13.

PMID:
29452248
7.

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells.

Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C.

Sci Rep. 2018 Jan 17;8(1):914. doi: 10.1038/s41598-018-19216-1.

8.

Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2).

Ha J, Xu Y, Kawano T, Hendon T, Baki L, Garai S, Papapetropoulos A, Thakur GA, Plant LD, Logothetis DE.

J Biol Chem. 2018 Mar 9;293(10):3546-3561. doi: 10.1074/jbc.RA117.001679. Epub 2018 Jan 9.

PMID:
29317494
9.

Inventing new therapies without reinventing the wheel: the power of drug repurposing.

Papapetropoulos A, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):165-167. doi: 10.1111/bph.14081.

10.

Epigenetics-by-Sex Interaction for Coronary Artery Disease Risk Conferred by the Cystathionine γ-Lyase Gene Promoter Methylation.

Giannakopoulou E, Konstantinou F, Ragia G, Tavridou A, Karaglani M, Chatzaki E, Papapetropoulos A, Mikroulis D, Manolopoulos VG.

OMICS. 2017 Dec;21(12):741-748. doi: 10.1089/omi.2017.0149. Epub 2017 Nov 27.

PMID:
29173085
11.

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A.

Redox Biol. 2018 Apr;14:694-696. doi: 10.1016/j.redox.2017.10.001. Epub 2017 Oct 26. No abstract available.

12.

Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells.

Untereiner AA, Pavlidou A, Druzhyna N, Papapetropoulos A, Hellmich MR, Szabo C.

Biochem Pharmacol. 2018 Mar;149:174-185. doi: 10.1016/j.bcp.2017.10.007. Epub 2017 Oct 20.

PMID:
29061341
13.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2017 Dec;174 Suppl 1:S1-S16. doi: 10.1111/bph.13882.

14.

Hydrogen Sulfide Preserves Endothelial Nitric Oxide Synthase Function by Inhibiting Proline-Rich Kinase 2: Implications for Cardiomyocyte Survival and Cardioprotection.

Bibli SI, Szabo C, Chatzianastasiou A, Luck B, Zukunft S, Fleming I, Papapetropoulos A.

Mol Pharmacol. 2017 Dec;92(6):718-730. doi: 10.1124/mol.117.109645. Epub 2017 Oct 13.

15.

Reduced adipose tissue H2S in obesity.

Katsouda A, Szabo C, Papapetropoulos A.

Pharmacol Res. 2018 Feb;128:190-199. doi: 10.1016/j.phrs.2017.09.023. Epub 2017 Oct 2.

PMID:
28982640
16.
17.

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A.

Redox Biol. 2017 Oct;13:94-162. doi: 10.1016/j.redox.2017.05.007. Epub 2017 May 18. Review. Erratum in: Redox Biol. 2018 Apr;14 :694-696.

18.

Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischaemic insult: role of PYK2.

Bibli SI, Zhou Z, Zukunft S, Fisslthaler B, Andreadou I, Szabo C, Brouckaert P, Fleming I, Papapetropoulos A.

Cardiovasc Res. 2017 Jul 1;113(8):926-937. doi: 10.1093/cvr/cvx058.

PMID:
28444132
19.

Reciprocal regulation of eNOS, H2S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin.

Sigala F, Efentakis P, Karageorgiadi D, Filis K, Zampas P, Iliodromitis EK, Zografos G, Papapetropoulos A, Andreadou I.

Redox Biol. 2017 Aug;12:70-81. doi: 10.1016/j.redox.2017.02.006. Epub 2017 Feb 12.

20.

Vascular biology of hydrogen sulfide.

Kanagy NL, Szabo C, Papapetropoulos A.

Am J Physiol Cell Physiol. 2017 May 1;312(5):C537-C549. doi: 10.1152/ajpcell.00329.2016. Epub 2017 Feb 1. Review.

21.

Exposure to cigarette smoke abrogates the beneficial effect of ischemic postconditioning.

Bibli SI, Andreadou I, Glynos C, Chatzianastasiou A, Toumpanakis D, Zakynthinos S, Vasilakopoulos T, Iliodromitis EK, Papapetropoulos A.

Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1321-H1332. doi: 10.1152/ajpheart.00925.2015. Epub 2016 Sep 30.

22.

Regulation and role of endogenously produced hydrogen sulfide in angiogenesis.

Katsouda A, Bibli SI, Pyriochou A, Szabo C, Papapetropoulos A.

Pharmacol Res. 2016 Nov;113(Pt A):175-185. doi: 10.1016/j.phrs.2016.08.026. Epub 2016 Aug 26. Review.

23.

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.

Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C.

Pharmacol Res. 2016 Nov;113(Pt A):18-37. doi: 10.1016/j.phrs.2016.08.016. Epub 2016 Aug 10.

24.

(1)H, (13)C, (15)N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the heme-nitric oxide/oxygen binding (H-NOX) domain.

Alexandropoulos II, Argyriou AI, Marousis KD, Topouzis S, Papapetropoulos A, Spyroulias GA.

Biomol NMR Assign. 2016 Oct;10(2):395-400. doi: 10.1007/s12104-016-9707-6. Epub 2016 Sep 10.

PMID:
27614467
25.

Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide.

Zhou Z, Martin E, Sharina I, Esposito I, Szabo C, Bucci M, Cirino G, Papapetropoulos A.

Pharmacol Res. 2016 Sep;111:556-562. doi: 10.1016/j.phrs.2016.06.029. Epub 2016 Jul 1.

26.

Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent Mechanisms.

Chatzianastasiou A, Bibli SI, Andreadou I, Efentakis P, Kaludercic N, Wood ME, Whiteman M, Di Lisa F, Daiber A, Manolopoulos VG, Szabó C, Papapetropoulos A.

J Pharmacol Exp Ther. 2016 Sep;358(3):431-40. doi: 10.1124/jpet.116.235119. Epub 2016 Jun 24.

27.

D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase.

Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T, Perretti M, Papapetropoulos A, Bucci M, Cirino G.

Br J Pharmacol. 2016 May;173(9):1556-65. doi: 10.1111/bph.13459. Epub 2016 Mar 23.

28.

Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents.

Lougiakis N, Papapetropoulos A, Gikas E, Toumpas S, Efentakis P, Wedmann R, Zoga A, Zhou Z, Iliodromitis EK, Skaltsounis AL, Filipovic MR, Pouli N, Marakos P, Andreadou I.

J Med Chem. 2016 Mar 10;59(5):1776-90. doi: 10.1021/acs.jmedchem.5b01223. Epub 2016 Feb 8.

PMID:
26809888
29.

Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes.

Andreadou I, Iliodromitis EK, Szabo C, Papapetropoulos A.

Basic Res Cardiol. 2015 Sep;110(5):510. doi: 10.1007/s00395-015-0510-9. Epub 2015 Aug 30.

30.

Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors.

Whiteman M, Perry A, Zhou Z, Bucci M, Papapetropoulos A, Cirino G, Wood ME.

Handb Exp Pharmacol. 2015;230:337-63. doi: 10.1007/978-3-319-18144-8_17. Review.

PMID:
26162843
31.

The role of H2S bioavailability in endothelial dysfunction.

Wang R, Szabo C, Ichinose F, Ahmed A, Whiteman M, Papapetropoulos A.

Trends Pharmacol Sci. 2015 Sep;36(9):568-78. doi: 10.1016/j.tips.2015.05.007. Epub 2015 Jun 9. Review.

32.

ATP-sensitive potassium channel activation induces angiogenesis in vitro and in vivo.

Umaru B, Pyriochou A, Kotsikoris V, Papapetropoulos A, Topouzis S.

J Pharmacol Exp Ther. 2015 Jul;354(1):79-87. doi: 10.1124/jpet.114.222000. Epub 2015 May 14.

33.

Pharmacology of the 'gasotransmitters' NO, CO and H2S: translational opportunities.

Papapetropoulos A, Foresti R, Ferdinandy P.

Br J Pharmacol. 2015 Mar;172(6):1395-6. doi: 10.1111/bph.13005. No abstract available.

34.

Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.

Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A.

Cardiovasc Res. 2015 Jun 1;106(3):432-42. doi: 10.1093/cvr/cvv129. Epub 2015 Apr 13.

35.

Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.

Coletta C, Módis K, Szczesny B, Brunyánszki A, Oláh G, Rios EC, Yanagi K, Ahmad A, Papapetropoulos A, Szabo C.

Mol Med. 2015 Feb 18;21:1-14. doi: 10.2119/molmed.2015.00035.

36.

Role of cGMP in hydrogen sulfide signaling.

Bibli SI, Yang G, Zhou Z, Wang R, Topouzis S, Papapetropoulos A.

Nitric Oxide. 2015 Apr 30;46:7-13. doi: 10.1016/j.niox.2014.12.004. Epub 2014 Dec 29. Review.

PMID:
25553675
37.

Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation.

Glynos C, Toumpanakis D, Loverdos K, Karavana V, Zhou Z, Magkou C, Dettoraki M, Perlikos F, Pavlidou A, Kotsikoris V, Topouzis S, Theocharis SE, Brouckaert P, Giannis A, Papapetropoulos A, Vassilakopoulos T.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):762-71. doi: 10.1165/rcmb.2014-0092OC.

PMID:
25353067
38.

Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS.

Papapetropoulos A, Hobbs AJ, Topouzis S.

Br J Pharmacol. 2015 Mar;172(6):1397-414. doi: 10.1111/bph.12980. Epub 2015 Jan 12. Review.

39.

Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.

Panza E, De Cicco P, Armogida C, Scognamiglio G, Gigantino V, Botti G, Germano D, Napolitano M, Papapetropoulos A, Bucci M, Cirino G, Ianaro A.

Pigment Cell Melanoma Res. 2015 Jan;28(1):61-72. doi: 10.1111/pcmr.12312. Epub 2014 Oct 6.

PMID:
25205294
40.

The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning.

Andreadou I, Iliodromitis EK, Rassaf T, Schulz R, Papapetropoulos A, Ferdinandy P.

Br J Pharmacol. 2015 Mar;172(6):1587-606. doi: 10.1111/bph.12811. Epub 2014 Sep 23. Review.

41.

Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners.

Papapetropoulos A, Whiteman M, Cirino G.

Br J Pharmacol. 2015 Mar;172(6):1633-7. doi: 10.1111/bph.12806. Epub 2014 Sep 5. Review.

42.

Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes.

Gerö D, Szoleczky P, Chatzianastasiou A, Papapetropoulos A, Szabo C.

Mol Med. 2014 Jul 31;20:313-28. doi: 10.2119/molmed.2014.00102.

43.

Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content.

Ghosh A, Stasch JP, Papapetropoulos A, Stuehr DJ.

J Biol Chem. 2014 May 30;289(22):15259-71. doi: 10.1074/jbc.M114.559393. Epub 2014 Apr 14.

44.

Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.

Módis K, Coletta C, Asimakopoulou A, Szczesny B, Chao C, Papapetropoulos A, Hellmich MR, Szabo C.

Nitric Oxide. 2014 Sep 15;41:146-56. doi: 10.1016/j.niox.2014.03.001. Epub 2014 Mar 22.

45.

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

Bucci M, Vellecco V, Cantalupo A, Brancaleone V, Zhou Z, Evangelista S, Calderone V, Papapetropoulos A, Cirino G.

Cardiovasc Res. 2014 Apr 1;102(1):138-47. doi: 10.1093/cvr/cvu026. Epub 2014 Feb 5.

PMID:
24501330
46.

Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics.

Rekowski MVW, Kumar V, Zhou Z, Moschner J, Marazioti A, Bantzi M, Spyroulias GA, van den Akker F, Giannis A, Papapetropoulos A.

J Med Chem. 2013 Nov 14;56(21):8948-8952. doi: 10.1021/jm400539d. Epub 2013 Oct 24.

47.

Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.

Módis K, Panopoulos P, Coletta C, Papapetropoulos A, Szabo C.

Biochem Pharmacol. 2013 Nov 1;86(9):1311-9. doi: 10.1016/j.bcp.2013.08.064. Epub 2013 Sep 4.

PMID:
24012591
48.

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects.

Módis K, Bos EM, Calzia E, van Goor H, Coletta C, Papapetropoulos A, Hellmich MR, Radermacher P, Bouillaud F, Szabo C.

Br J Pharmacol. 2014 Apr;171(8):2123-46. doi: 10.1111/bph.12368. Review.

49.

The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease.

Glynos C, Dupont LL, Vassilakopoulos T, Papapetropoulos A, Brouckaert P, Giannis A, Joos GF, Bracke KR, Brusselle GG.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):789-99. doi: 10.1164/rccm.201210-1884OC.

PMID:
23841447
50.

Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer.

Szabo C, Coletta C, Chao C, Módis K, Szczesny B, Papapetropoulos A, Hellmich MR.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12474-9. doi: 10.1073/pnas.1306241110. Epub 2013 Jul 8.

51.

Modulation of the release of Ang-2 in experimental endotoxic shock by a species-specific circulating factor.

Carrer DP, Kotzampassi K, Fyntanidou B, Grosomanidis V, Papapetropoulos A, Lymperi M, Giamarellos-Bourboulis EJ.

Injury. 2013 Jul;44(7):935-40. doi: 10.1016/j.injury.2013.03.031. Epub 2013 May 1.

PMID:
23642845
52.

Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway.

Módis K, Asimakopoulou A, Coletta C, Papapetropoulos A, Szabo C.

Biochem Biophys Res Commun. 2013 Apr 19;433(4):401-7. doi: 10.1016/j.bbrc.2013.02.131. Epub 2013 Mar 26.

PMID:
23537657
53.

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).

Asimakopoulou A, Panopoulos P, Chasapis CT, Coletta C, Zhou Z, Cirino G, Giannis A, Szabo C, Spyroulias GA, Papapetropoulos A.

Br J Pharmacol. 2013 Jun;169(4):922-32. doi: 10.1111/bph.12171.

54.

cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation.

Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Zaid A, Giannogonas P, Cantalupo A, Dhayade S, Karalis KP, Wang R, Feil R, Cirino G.

PLoS One. 2012;7(12):e53319. doi: 10.1371/journal.pone.0053319. Epub 2012 Dec 28.

55.

PDE5 inhibition against acute renal ischemia reperfusion injury in rats: does vardenafil offer protection?

Kyriazis I, Kagadis GC, Kallidonis P, Georgiopoulos I, Marazioti A, Geronasiou A, Liourdi D, Loudos G, Schinas V, Apostolopoulos D, Papadaki H, Flordellis C, Nikiforidis GC, Papapetropoulos A, Liatsikos EN.

World J Urol. 2013 Jun;31(3):597-602. doi: 10.1007/s00345-012-0980-4. Epub 2012 Nov 10.

PMID:
23143734
56.

Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics.

Módis K, Coletta C, Erdélyi K, Papapetropoulos A, Szabo C.

FASEB J. 2013 Feb;27(2):601-11. doi: 10.1096/fj.12-216507. Epub 2012 Oct 26.

PMID:
23104984
57.

Nitric oxide regulates cytokine induction in the diaphragm in response to inspiratory resistive breathing.

Sigala I, Zacharatos P, Boulia S, Toumpanakis D, Michailidou T, Parthenis D, Roussos C, Papapetropoulos A, Hussain SN, Vassilakopoulos T.

J Appl Physiol (1985). 2012 Nov;113(10):1594-603. doi: 10.1152/japplphysiol.00233.2012. Epub 2012 Sep 6.

58.

Angiopoietin-2 enhances survival in experimental sepsis induced by multidrug-resistant Pseudomonas aeruginosa.

Tzepi IM, Giamarellos-Bourboulis EJ, Carrer DP, Tsaganos T, Claus RA, Vaki I, Pelekanou A, Kotsaki A, Tziortzioti V, Topouzis S, Bauer M, Papapetropoulos A.

J Pharmacol Exp Ther. 2012 Nov;343(2):278-87. doi: 10.1124/jpet.112.195180. Epub 2012 Aug 2.

59.

Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model.

Crassous PA, Couloubaly S, Huang C, Zhou Z, Baskaran P, Kim DD, Papapetropoulos A, Fioramonti X, Durán WN, Beuve A.

Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H597-604. doi: 10.1152/ajpheart.00138.2012. Epub 2012 Jun 22.

60.

Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation.

Coletta C, Papapetropoulos A, Erdelyi K, Olah G, Módis K, Panopoulos P, Asimakopoulou A, Gerö D, Sharina I, Martin E, Szabo C.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9161-6. doi: 10.1073/pnas.1202916109. Epub 2012 May 8.

61.

Thioglycine and L-thiovaline: biologically active H₂S-donors.

Zhou Z, von Wantoch Rekowski M, Coletta C, Szabo C, Bucci M, Cirino G, Topouzis S, Papapetropoulos A, Giannis A.

Bioorg Med Chem. 2012 Apr 15;20(8):2675-8. doi: 10.1016/j.bmc.2012.02.028. Epub 2012 Feb 27.

PMID:
22436388
62.

Short-term statin administration in hypercholesterolaemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase, and nitro-oxidative stress.

Andreadou I, Farmakis D, Prokovas E, Sigala F, Zoga A, Spyridaki K, Papalois A, Papapetropoulos A, Anastasiou-Nana M, Kremastinos DT, Iliodromitis EK.

Cardiovasc Res. 2012 Jun 1;94(3):501-9. doi: 10.1093/cvr/cvs121. Epub 2012 Mar 12.

PMID:
22411971
63.

A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization.

Palmer GM, Tiran Z, Zhou Z, Capozzi ME, Park W, Coletta C, Pyriochou A, Kliger Y, Levy O, Borukhov I, Dewhirst MW, Rotman G, Penn JS, Papapetropoulos A.

Br J Pharmacol. 2012 Mar;165(6):1891-1903. doi: 10.1111/j.1476-5381.2011.01677.x.

64.

Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules.

Marazioti A, Bucci M, Coletta C, Vellecco V, Baskaran P, Szabó C, Cirino G, Marques AR, Guerreiro B, Gonçalves AM, Seixas JD, Beuve A, Romão CC, Papapetropoulos A.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2570-6. doi: 10.1161/ATVBAHA.111.229039.

PMID:
21836072
65.

Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.

Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gerö D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A, Szabo C.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13829-34. doi: 10.1073/pnas.1105121108. Epub 2011 Aug 1.

66.

MAPKs and NF-κB differentially regulate cytokine expression in the diaphragm in response to resistive breathing: the role of oxidative stress.

Sigala I, Zacharatos P, Toumpanakis D, Michailidou T, Noussia O, Theocharis S, Roussos C, Papapetropoulos A, Vassilakopoulos T.

Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1152-62. doi: 10.1152/ajpregu.00376.2010. Epub 2011 Feb 16.

67.

Hydrogen sulphide and angiogenesis: mechanisms and applications.

Szabó C, Papapetropoulos A.

Br J Pharmacol. 2011 Oct;164(3):853-65. doi: 10.1111/j.1476-5381.2010.01191.x. Review.

68.

Mastic oil inhibits the metastatic phenotype of mouse lung adenocarcinoma cells.

Loutrari H, Magkouta S, Papapetropoulos A, Roussos C.

Cancers (Basel). 2011 Feb 23;3(1):789-801. doi: 10.3390/cancers3010789.

69.

PKG-I inhibition attenuates vascular endothelial growth factor-stimulated angiogenesis.

Koika V, Zhou Z, Vasileiadis I, Roussos C, Finetti F, Monti M, Morbidelli L, Papapetropoulos A.

Vascul Pharmacol. 2010 Nov-Dec;53(5-6):215-22. doi: 10.1016/j.vph.2010.08.004. Epub 2010 Sep 8.

PMID:
20813203
70.

Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.

Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Pyriochou A, Roussos C, Roviezzo F, Brancaleone V, Cirino G.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1998-2004. doi: 10.1161/ATVBAHA.110.209783. Epub 2010 Jul 15.

PMID:
20634473
71.

Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase.

von Wantoch Rekowski M, Pyriochou A, Papapetropoulos N, Stössel A, Papapetropoulos A, Giannis A.

Bioorg Med Chem. 2010 Feb;18(3):1288-96. doi: 10.1016/j.bmc.2009.12.027. Epub 2009 Dec 23.

PMID:
20036129
72.

Nitric oxide stimulates interleukin-6 production in skeletal myotubes.

Makris AC, Sotzios Y, Zhou Z, Makropoulou M, Papapetropoulos N, Zacharatos P, Pyriochou A, Roussos C, Papapetropoulos A, Vassilakopoulos T.

J Interferon Cytokine Res. 2010 May;30(5):321-7. doi: 10.1089/jir.2009.0022.

PMID:
20035621
73.

The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.

Morbidelli L, Pyriochou A, Filippi S, Vasileiadis I, Roussos C, Zhou Z, Loutrari H, Waltenberger J, Stössel A, Giannis A, Ziche M, Papapetropoulos A.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R824-32. doi: 10.1152/ajpregu.00222.2009. Epub 2009 Dec 23.

74.

Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN.

Church JE, Qian J, Kumar S, Black SM, Venema RC, Papapetropoulos A, Fulton DJ.

Vascul Pharmacol. 2010 May-Jun;52(5-6):191-8. doi: 10.1016/j.vph.2009.11.007. Epub 2009 Dec 3.

75.

Hydrogen sulfide is an endogenous stimulator of angiogenesis.

Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschke MG, Branski LK, Herndon DN, Wang R, Szabó C.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21972-7. doi: 10.1073/pnas.0908047106. Epub 2009 Dec 2.

76.

Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma.

Magkouta S, Stathopoulos GT, Psallidas I, Papapetropoulos A, Kolisis FN, Roussos C, Loutrari H.

Nutr Cancer. 2009;61(5):640-8. doi: 10.1080/01635580902825647.

PMID:
19838938
77.

Antioxidant supplementation alters cytokine production from monocytes.

Toumpanakis D, Karatza MH, Katsaounou P, Roussos C, Zakynthinos S, Papapetropoulos A, Vassilakopoulos T.

J Interferon Cytokine Res. 2009 Nov;29(11):741-8. doi: 10.1089/jir.2008.0114.

PMID:
19642904
78.

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase.

Spyridonidou K, Fousteris M, Antonia M, Chatzianastasiou A, Papapetropoulos A, Nikolaropoulos S.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4810-3. doi: 10.1016/j.bmcl.2009.06.047. Epub 2009 Jun 14.

PMID:
19560917
79.

Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes.

Kranidioti H, Orfanos SE, Vaki I, Kotanidou A, Raftogiannis M, Dimopoulou I, Kotsaki A, Savva A, Papapetropoulos A, Armaganidis A, Giamarellos-Bourboulis EJ.

Immunol Lett. 2009 Jun 30;125(1):65-71. doi: 10.1016/j.imlet.2009.06.006. Epub 2009 Jun 17.

PMID:
19539650
80.

ADMA injures the glomerular filtration barrier: role of nitric oxide and superoxide.

Sharma M, Zhou Z, Miura H, Papapetropoulos A, McCarthy ET, Sharma R, Savin VJ, Lianos EA.

Am J Physiol Renal Physiol. 2009 Jun;296(6):F1386-95. doi: 10.1152/ajprenal.90369.2008. Epub 2009 Mar 18.

81.

The angiopoietin/Tie2 axis mediates malignant pleural effusion formation.

Moschos C, Psallidas I, Kollintza A, Karabela S, Papapetropoulos A, Papiris S, Light RW, Roussos C, Stathopoulos GT, Kalomenidis I.

Neoplasia. 2009 Mar;11(3):298-304.

82.

Breath markers of oxidative stress and airway inflammation in Seasonal Allergic Rhinitis.

Gratziou C, Rovina N, Makris M, Simoes DC, Papapetropoulos A, Roussos C.

Int J Immunopathol Pharmacol. 2008 Oct-Dec;21(4):949-57.

PMID:
19144280
83.

Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress.

Zhou Z, Pyriochou A, Kotanidou A, Dalkas G, van Eickels M, Spyroulias G, Roussos C, Papapetropoulos A.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1763-71. doi: 10.1152/ajpheart.51.2008. Epub 2008 Aug 29.

84.

cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines.

Haramis G, Zhou Z, Pyriochou A, Koutsilieris M, Roussos C, Papapetropoulos A.

Br J Pharmacol. 2008 Nov;155(6):804-13. doi: 10.1038/bjp.2008.312. Epub 2008 Aug 11.

85.

Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.

Zhou Z, Sayed N, Pyriochou A, Roussos C, Fulton D, Beuve A, Papapetropoulos A.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1803-10. doi: 10.1161/ATVBAHA.108.165043. Epub 2008 Jul 17.

86.

Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34.

Pyriochou A, Olah G, Deitch EA, Szabó C, Papapetropoulos A.

Int J Mol Med. 2008 Jul;22(1):113-8.

PMID:
18575783
87.

Angiopoietin-1 protects against airway inflammation and hyperreactivity in asthma.

Simoes DC, Vassilakopoulos T, Toumpanakis D, Petrochilou K, Roussos C, Papapetropoulos A.

Am J Respir Crit Care Med. 2008 Jun 15;177(12):1314-21. doi: 10.1164/rccm.200708-1141OC. Epub 2008 Mar 20.

PMID:
18356565
88.

Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents.

Fotopoulou T, Iliodromitis EK, Koufaki M, Tsotinis A, Zoga A, Gizas V, Pyriochou A, Papapetropoulos A, Andreadou I, Kremastinos DT.

Bioorg Med Chem. 2008 Apr 15;16(8):4523-31. doi: 10.1016/j.bmc.2008.02.051. Epub 2008 Feb 20.

PMID:
18328715
89.

The insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) in Parkinson's disease.

Papapetropoulos S, Glynos K, Zhou Z, Orfanos SE, Mitsi G, Papapetropoulos A.

Open Neurol J. 2008 Oct 31;2:66-70. doi: 10.2174/1874205X00802010066.

90.

Anti-angiogenic properties of a sulindac analogue.

Pyriochou A, Tsigkos S, Vassilakopoulos T, Cottin T, Zhou Z, Gourzoulidou E, Roussos C, Waldmann H, Giannis A, Papapetropoulos A.

Br J Pharmacol. 2007 Dec;152(8):1207-14. Epub 2007 Oct 29.

91.

Automated angiogenesis quantification through advanced image processing techniques.

Doukas CN, Maglogiannis I, Chatziioannou A, Papapetropoulos A.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:2345-8.

PMID:
17946107
92.

cGMP-dependent and -independent angiogenesis-related properties of nitric oxide.

Pyriochou A, Vassilakopoulos T, Zhou Z, Papapetropoulos A.

Life Sci. 2007 Nov 10;81(21-22):1549-54. Epub 2007 Oct 2.

PMID:
17945311
93.

Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase.

Xia T, Dimitropoulou C, Zeng J, Antonova GN, Snead C, Venema RC, Fulton D, Qian S, Patterson C, Papapetropoulos A, Catravas JD.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3080-7. Epub 2007 Sep 14.

94.

Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cells.

Li C, Ruan L, Sood SG, Papapetropoulos A, Fulton D, Venema RC.

Vascul Pharmacol. 2007 Nov-Dec;47(5-6):257-64. Epub 2007 Aug 9.

95.
96.
97.

Regulation of the expression of soluble guanylyl cyclase by reactive oxygen species.

Gerassimou C, Kotanidou A, Zhou Z, Simoes DC, Roussos C, Papapetropoulos A.

Br J Pharmacol. 2007 Apr;150(8):1084-91. Epub 2007 Mar 5. Erratum in: Br J Pharmacol. 2007 Apr;150(8):1092. Simoes, D D C [corrected to Simoes, D C M].

98.

The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway.

Pyriochou A, Zhou Z, Koika V, Petrou C, Cordopatis P, Sessa WC, Papapetropoulos A.

J Cell Physiol. 2007 Apr;211(1):197-204.

PMID:
17226792
99.

Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury.

Glynos C, Kotanidou A, Orfanos SE, Zhou Z, Simoes DC, Magkou C, Roussos C, Papapetropoulos A.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1448-55. Epub 2007 Jan 4.

100.

Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators.

Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C, Zakynthinos S, Armaganidis A, Papapetropoulos A, Roussos C.

Crit Care Med. 2007 Jan;35(1):199-206. Erratum in: Crit Care Med. 2007 Apr;35(4):1224.

PMID:
17110873
101.

Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis.

Loutrari H, Magkouta S, Pyriochou A, Koika V, Kolisis FN, Papapetropoulos A, Roussos C.

Nutr Cancer. 2006;55(1):86-93.

PMID:
16965245
102.

Inhaled activated protein C attenuates lung injury induced by aerosolized endotoxin in mice.

Kotanidou A, Loutrari H, Papadomichelakis E, Glynos C, Magkou C, Armaganidis A, Papapetropoulos A, Roussos C, Orfanos SE.

Vascul Pharmacol. 2006 Aug;45(2):134-40. Epub 2006 Jul 25.

PMID:
16959545
103.

Soluble guanylyl cyclase activation promotes angiogenesis.

Pyriochou A, Beis D, Koika V, Potytarchou C, Papadimitriou E, Zhou Z, Papapetropoulos A.

J Pharmacol Exp Ther. 2006 Nov;319(2):663-71. Epub 2006 Aug 29.

104.

Angiopoietin-2 levels are elevated in exudative pleural effusions.

Kalomenidis I, Kollintza A, Sigala I, Papapetropoulos A, Papiris S, Light RW, Roussos C.

Chest. 2006 May;129(5):1259-66.

PMID:
16685017
105.

Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses.

Psarras S, Volonaki E, Skevaki CL, Xatzipsalti M, Bossios A, Pratsinis H, Tsigkos S, Gourgiotis D, Constantopoulos AG, Papapetropoulos A, Saxoni-Papageorgiou P, Papadopoulos NG.

J Allergy Clin Immunol. 2006 Feb;117(2):291-7.

PMID:
16461129
106.

Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells.

Tsigkos S, Zhou Z, Kotanidou A, Fulton D, Zakynthinos S, Roussos C, Papapetropoulos A.

J Cell Physiol. 2006 May;207(2):506-11. Erratum in: J Cell Physiol. 2006 Oct;209(1):239.

PMID:
16447257
107.

Soluble guanylyl cyclase expression is reduced in allergic asthma.

Papapetropoulos A, Simoes DC, Xanthou G, Roussos C, Gratziou C.

Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L179-84. Epub 2005 Sep 2.

108.

Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding.

Papapetropoulos A, Zhou Z, Gerassimou C, Yetik G, Venema RC, Roussos C, Sessa WC, Catravas JD.

Mol Pharmacol. 2005 Oct;68(4):1133-41. Epub 2005 Jul 15.

109.

Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage.

Roviezzo F, Tsigkos S, Kotanidou A, Bucci M, Brancaleone V, Cirino G, Papapetropoulos A.

J Pharmacol Exp Ther. 2005 Aug;314(2):738-44. Epub 2005 May 3.

110.

Soluble guanylyl cyclase: more secrets revealed.

Pyriochou A, Papapetropoulos A.

Cell Signal. 2005 Apr;17(4):407-13. Review.

PMID:
15601619
111.

Effects of modulation of the NO/cGMP pathway in tumor cell lines derived from the upper airway tract.

Papapetropoulos N, Zhou Z, Roussos C, Goumas P, Papapetropoulos A.

Pharmacology. 2004 Nov;72(3):167-76.

PMID:
15452365
112.

Perillyl alcohol is an angiogenesis inhibitor.

Loutrari H, Hatziapostolou M, Skouridou V, Papadimitriou E, Roussos C, Kolisis FN, Papapetropoulos A.

J Pharmacol Exp Ther. 2004 Nov;311(2):568-75. Epub 2004 Jun 21.

113.

Structural and functional characterization of the dimerization region of soluble guanylyl cyclase.

Zhou Z, Gross S, Roussos C, Meurer S, Müller-Esterl W, Papapetropoulos A.

J Biol Chem. 2004 Jun 11;279(24):24935-43. Epub 2004 Mar 22.

114.

Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein.

Papapetropoulos A, Fulton D, Lin MI, Fontana J, McCabe TJ, Zoellner S, García-Cardeña G, Zhou Z, Gratton JP, Sessa WC.

Mol Pharmacol. 2004 Feb;65(2):407-15.

115.

Angiopoietins in angiogenesis and beyond.

Tsigkos S, Koutsilieris M, Papapetropoulos A.

Expert Opin Investig Drugs. 2003 Jun;12(6):933-41. Review.

PMID:
12783598
116.

Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production.

Pizurki L, Zhou Z, Glynos K, Roussos C, Papapetropoulos A.

Br J Pharmacol. 2003 May;139(2):329-36.

117.

Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin.

Xagorari A, Roussos C, Papapetropoulos A.

Br J Pharmacol. 2002 Aug;136(7):1058-64.

118.

Production of interleukin-6 by skeletal myotubes: role of reactive oxygen species.

Kosmidou I, Vassilakopoulos T, Xagorari A, Zakynthinos S, Papapetropoulos A, Roussos C.

Am J Respir Cell Mol Biol. 2002 May;26(5):587-93.

PMID:
11970911
119.

Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice.

Kotanidou A, Xagorari A, Bagli E, Kitsanta P, Fotsis T, Papapetropoulos A, Roussos C.

Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23.

PMID:
11897650
120.

Regulation of the nitric oxide synthase-nitric oxide-cGMP pathway in rat mesenteric endothelial cells.

Papapetropoulos A, Andreopoulos S, Go CY, Hoque A, Fuchs LC, Catravas JD.

J Appl Physiol (1985). 2001 Dec;91(6):2553-60.

121.

Reactive oxygen species stimulate VEGF production from C(2)C(12) skeletal myotubes through a PI3K/Akt pathway.

Kosmidou I, Xagorari A, Roussos C, Papapetropoulos A.

Am J Physiol Lung Cell Mol Physiol. 2001 Apr;280(4):L585-92.

122.

Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.

Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T, Roussos C.

J Pharmacol Exp Ther. 2001 Jan;296(1):181-7.

123.

Molecular aspects of soluble guanylyl cyclase regulation.

Andreopoulos S, Papapetropoulos A.

Gen Pharmacol. 2000 Mar;34(3):147-57. Review.

PMID:
11120376
124.

Reduced lung endothelial angiotensin-converting enzyme activity in Watanabe hyperlipidemic rabbits in vivo.

Orfanos SE, Parkerson JB, Chen X, Fisher EL, Glynos C, Papapetropoulos A, Gerrity RG, Catravas JD.

Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1280-8.

125.

Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway.

Papapetropoulos A, Fulton D, Mahboubi K, Kalb RG, O'Connor DS, Li F, Altieri DC, Sessa WC.

J Biol Chem. 2000 Mar 31;275(13):9102-5.

126.

Molecular control of nitric oxide synthases in the cardiovascular system.

Papapetropoulos A, Rudic RD, Sessa WC.

Cardiovasc Res. 1999 Aug 15;43(3):509-20. Review.

PMID:
10690323
127.

Quantification of eNOS mRNA in the canine cardiac vasculature by competitive PCR.

Fulton D, Papapetropoulos A, Zhang X, Catravas JD, Hintze TH, Sessa WC.

Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H658-65.

128.

Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat.

Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, Sessa WC, Groszmann RJ.

Gastroenterology. 1999 Nov;117(5):1222-8.

PMID:
10535886
129.
130.

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.

Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC.

Nature. 1999 Jun 10;399(6736):597-601. Erratum in: Nature 1999 Aug 19;400(6746):792.

131.

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

Papapetropoulos A, García-Cardeña G, Dengler TJ, Maisonpierre PC, Yancopoulos GD, Sessa WC.

Lab Invest. 1999 Feb;79(2):213-23.

PMID:
10068209
132.

Biological action of leptin as an angiogenic factor.

Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR.

Science. 1998 Sep 11;281(5383):1683-6.

133.

Neuronal nitric oxide synthase is expressed in principal cell of collecting duct.

Wang X, Lu M, Gao Y, Papapetropoulos A, Sessa WC, Wang W.

Am J Physiol. 1998 Sep;275(3 Pt 2):F395-9.

PMID:
9729512
134.

Effects of antisense oligonucleotide to iNOS on hemodynamic and vascular changes induced by LPS.

Hoque AM, Papapetropoulos A, Venema RC, Catravas JD, Fuchs LC.

Am J Physiol. 1998 Sep;275(3 Pt 2):H1078-83.

PMID:
9724316
135.

Cross-tolerance between endogenous nitric oxide and exogenous nitric oxide donors.

Papapetropoulos A, Marczin N, Catravas JD.

Eur J Pharmacol. 1998 Mar 5;344(2-3):313-21.

PMID:
9600668
136.

Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: implication in its anti-inflammatory activity.

Abou-Mohamed G, Papapetropoulos A, Catravas JD, Caldwell RW.

Eur J Pharmacol. 1998 Jan 12;341(2-3):265-72.

PMID:
9543248
137.

Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling.

Papapetropoulos A, Piccardoni P, Cirino G, Bucci M, Sorrentino R, Cicala C, Johnson K, Zachariou V, Sessa WC, Altieri DC.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4738-42.

138.

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC.

Nature. 1998 Apr 23;392(6678):821-4.

PMID:
9580552
139.

Induction of nitric oxide synthase by protein synthesis inhibition in aortic smooth muscle cells.

Marczin N, Go CY, Papapetropoulos A, Catravas JD.

Br J Pharmacol. 1998 Mar;123(5):1000-8.

140.

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC.

J Clin Invest. 1997 Dec 15;100(12):3131-9.

141.

Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro.

Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC.

Am J Pathol. 1997 May;150(5):1835-44.

142.

Relationship between volume of bathing medium and ectoenzyme activity in monolayers of cultured BPAEC.

Papapetropoulos A, Elmore LA, Catravas JD.

Am J Physiol. 1996 Sep;271(3 Pt 1):L464-9.

PMID:
8843796
143.

Monocyte-induced downregulation of nitric oxide synthase in cultured aortic endothelial cells.

Marczin N, Antonov A, Papapetropoulos A, Munn DH, Virmani R, Kolodgie FD, Gerrity R, Catravas JD.

Arterioscler Thromb Vasc Biol. 1996 Sep;16(9):1095-103.

PMID:
8792762
144.

Monocyte- and cytokine-induced downregulation of angiotensin-converting enzyme in cultured human and porcine endothelial cells.

Papapetropoulos A, Antonov A, Virmani R, Kolodgie FD, Munn DH, Marczin N, Ryan JW, Gerrity RG, Catravas JD.

Circ Res. 1996 Sep;79(3):512-23.

PMID:
8781484
145.

Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta.

Papapetropoulos A, Abou-Mohamed G, Marczin N, Murad F, Caldwell RW, Catravas JD.

Br J Pharmacol. 1996 Jul;118(6):1359-66.

146.

Cytoskeleton-dependent activation of the inducible nitric oxide synthase in cultured aortic smooth muscle cells.

Marczin N, Jilling T, Papapetropoulos A, Go C, Catravas JD.

Br J Pharmacol. 1996 Jul;118(5):1085-94.

147.

Human aortic endothelial cell aminopeptidase N.

Papapetropoulos A, Ryan JW, Antonov A, Virmani R, Kolodgie FD, Gerrity RG, Catravas JD.

Immunopharmacology. 1996 May;32(1-3):153-6. No abstract available.

PMID:
8796295
148.

Aminopeptidase P is disposed on human endothelial cells.

Ryan JW, Papapetropoulos A, Ju H, Denslow ND, Antonov A, Virmani R, Kolodgie FD, Gerrity RG, Catravas JD.

Immunopharmacology. 1996 May;32(1-3):149-52. No abstract available.

PMID:
8796294
149.

cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.

Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD.

J Cell Physiol. 1996 May;167(2):213-21.

PMID:
8613461
150.

Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells.

Papapetropoulos A, Go CY, Murad F, Catravas JD.

Br J Pharmacol. 1996 Jan;117(1):147-55.

151.

HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro.

Abou-Mohamed G, Papapetropoulos A, Ulrich D, Catravas JD, Tuttle RR, Caldwell RW.

J Pharmacol Exp Ther. 1995 Nov;275(2):584-91.

PMID:
7473142
152.

Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA, and protein levels by cAMP-elevating agents.

Papapetropoulos A, Marczin N, Mora G, Milici A, Murad F, Catravas JD.

Hypertension. 1995 Oct;26(4):696-704.

PMID:
7558233
153.

Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporine in choriocarcinoma cells.

Ramamoorthy JD, Ramamoorthy S, Papapetropoulos A, Catravas JD, Leibach FH, Ganapathy V.

J Biol Chem. 1995 Jul 21;270(29):17189-95.

154.

Smooth muscle cell responsiveness to nitrovasodilators in hypertensive and normotensive rats.

Papapetropoulos A, Marczin N, Snead MD, Cheng C, Milici A, Catravas JD.

Hypertension. 1994 Apr;23(4):476-84.

PMID:
7511569
155.

Tyrosine kinase inhibitors suppress endotoxin- and IL-1 beta-induced NO synthesis in aortic smooth muscle cells.

Marczin N, Papapetropoulos A, Catravas JD.

Am J Physiol. 1993 Sep;265(3 Pt 2):H1014-8.

PMID:
8214107
156.

Prevention of nitric oxide synthase induction in vascular smooth muscle cells by microtubule depolymerizing agents.

Marczin N, Papapetropoulos A, Jilling T, Catravas JD.

Br J Pharmacol. 1993 Jul;109(3):603-5.

157.

Radiation-induced alterations in angiotensin converting enzyme activity in cultured bovine pulmonary arterial endothelial cell monolayers.

Papapetropoulos A, Burch SE, Topouzis S, Catravas JD.

Toxicol Appl Pharmacol. 1993 May;120(1):96-105.

PMID:
8390115

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