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1.

Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside.

Seely AJ, Kauffman SA, Bates JH, Macklem PT, Suki B, Marshall JC, Batchinsky AI, Perez-Velazquez JL, Seiver A, McGregor C, Maksym G, Kamath MV, Similowski T, Buchman TG, Letellier C, Filoche M, Frasch MG, Straus C, Glass L, Godin PJ, Morris JA, Sow D, Nenadovic V, Arnold RC, Norris P, Moorman JR.

J Crit Care. 2011 Jun;26(3):325-7. doi: 10.1016/j.jcrc.2011.04.002. No abstract available.

PMID:
21616298
2.

Susceptibility to exacerbation in COPD.

Macklem PT.

N Engl J Med. 2010 Dec 30;363(27):2670; author reply 2671. doi: 10.1056/NEJMc1011871. No abstract available.

PMID:
21190466
3.

[Open letter to the members of the GOLD committee].

Le groupe Pulmonaria, Quanjer PH, Enright PL, Stocks J, Ruppel G, Swanney MP, Crapo RO, Pedersen OF, Falaschetti E, Schouten JP, Jensen RL; ANZSRS : Australian and New Zealand Society of Respiratory; ARTP : Association for Respiratory Technology and Physiology; CAHAG : COPD and Astma Huisartsen Advies Groep (COPD and Asthma GP Advisory Group); SKL : Dutch Paediatric Repiratory Society; Education for Health, Warwick, UK; National Respiratory Training Center, Virginia, US; NHG : Nederlands Huisartsen Genootschap (Dutch Society of GPs); NVALT : Nederlandse Vereniging van Artsen voor Longziekten en Tuberculose (Dutch Thoracic Society); NVLA : Nederlandse Vereniging Longfunctie Analisten (Dutch Society of Respiratory Technicians); PCRS-UK : Primary Care Respiratory Society UK; Société de Physiologie; SPLF : Société de pneumologie de langue franc¸aise; SSMG : Société scientifique de médecine générale; WONCA: World Organization of Family Doctors.

Rev Mal Respir. 2010 Nov;27(9):1003-7. doi: 10.1016/j.rmr.2010.09.007. Epub 2010 Oct 8. French. No abstract available.

PMID:
21111268
4.

Concomitant ventilatory and circulatory functions of the diaphragm and abdominal muscles.

Aliverti A, Uva B, Laviola M, Bovio D, Lo Mauro A, Tarperi C, Colombo E, Loomas B, Pedotti A, Similowski T, Macklem PT.

J Appl Physiol (1985). 2010 Nov;109(5):1432-40. doi: 10.1152/japplphysiol.00576.2010. Epub 2010 Sep 2.

5.

Towards a definition of life.

Macklem PT, Seely A.

Perspect Biol Med. 2010 Summer;53(3):330-40. doi: 10.1353/pbm.0.0167.

PMID:
20639603
6.

Therapeutic implications of the pathophysiology of COPD.

Macklem PT.

Eur Respir J. 2010 Mar;35(3):676-80. doi: 10.1183/09031936.00120609. Review.

7.

Stephen Hales, an unrecognized giant of medicine.

Macklem PT.

Osler Libr Newsl. 2010;(114):1-4. No abstract available.

PMID:
21542394
8.

In memoriam: Jere Mead (1920-2009).

Macklem PT.

J Appl Physiol (1985). 2009 Dec;107(6):1679. doi: 10.1152/japplphysiol.01125.2009. Epub 2009 Oct 8. No abstract available.

9.

Quantification of trapped gas with CT and 3 He MR imaging in a porcine model of isolated airway obstruction.

Salito C, Aliverti A, Gierada DS, Deslée G, Pierce RA, Macklem PT, Woods JC.

Radiology. 2009 Nov;253(2):380-9. doi: 10.1148/radiol.2532081941. Epub 2009 Jul 31.

10.

The abdominal circulatory pump.

Aliverti A, Bovio D, Fullin I, Dellacà RL, Lo Mauro A, Pedotti A, Macklem PT.

PLoS One. 2009;4(5):e5550. doi: 10.1371/journal.pone.0005550. Epub 2009 May 14.

11.
12.

The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles.

Aliverti A, Macklem PT.

J Appl Physiol (1985). 2008 Aug;105(2):749-51; discussion 755-7. doi: 10.1152/japplphysiol.90336.2008. Epub 2008 Mar 20. No abstract available.

13.

Airway bypass improves the mechanical properties of explanted emphysematous lungs.

Choong CK, Macklem PT, Pierce JA, Das N, Lutey BA, Martinez CO, Cooper JD.

Am J Respir Crit Care Med. 2008 Nov 1;178(9):902-5. doi: 10.1164/rccm.200712-1832OC. Epub 2008 Jul 31.

14.

Dividing the FEV1 into its component parts.

Macklem PT, Irvin CG.

J Appl Physiol (1985). 2008 Jul;105(1):392; author reply 393. doi: 10.1152/japplphysiol.90489.2008. No abstract available.

15.

At Last! A Realistic Animal Model of Severe Asthma.

Macklem PT.

Am J Respir Crit Care Med. 2008 Feb 1;177(3):245-6. No abstract available.

PMID:
18246600
16.

Emergent phenomena and the secrets of life.

Macklem PT.

J Appl Physiol (1985). 2008 Jun;104(6):1844-6. doi: 10.1152/japplphysiol.00942.2007. Epub 2008 Jan 17. No abstract available.

17.

Chest wall dynamics and muscle recruitment during professional flute playing.

Cossette I, Monaco P, Aliverti A, Macklem PT.

Respir Physiol Neurobiol. 2008 Feb 1;160(2):187-95. Epub 2007 Sep 21.

PMID:
17977805
18.

Canada's contribution to respiratory physiology and pathophysiology.

Macklem PT.

Can Respir J. 2007 Oct;14(7):383-92. No abstract available.

19.

Percolation and phase transitions.

Fessler HE, Macklem PT.

Am J Respir Crit Care Med. 2007 Sep 15;176(6):530-1. No abstract available.

PMID:
17823359
20.

Bronchial thermoplasty.

Macklem PT.

N Engl J Med. 2007 Jun 28;356(26):2744; author reply 2745. No abstract available.

PMID:
17596611
21.

A human model of the pathophysiology of chronic obstructive pulmonary disease.

Aliverti A, Kayser B, Macklem PT.

Respirology. 2007 Jul;12(4):478-85. Review.

PMID:
17587412
22.

Transpleural ventilation of explanted human lungs.

Choong CK, Macklem PT, Pierce JA, Lefrak SS, Woods JC, Conradi MS, Yablonskiy DA, Hogg JC, Chino K, Cooper JD.

Thorax. 2007 Jul;62(7):623-30. Epub 2007 Apr 5.

23.

Oxygen kinetics and debt during recovery from expiratory flow-limited exercise in healthy humans.

Vogiatzis I, Zakynthinos S, Georgiadou O, Golemati S, Pedotti A, Macklem PT, Roussos C, Aliverti A.

Eur J Appl Physiol. 2007 Feb;99(3):265-74. Epub 2006 Dec 6.

24.

Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema.

Woods JC, Choong CK, Yablonskiy DA, Bentley J, Wong J, Pierce JA, Cooper JD, Macklem PT, Conradi MS, Hogg JC.

Magn Reson Med. 2006 Dec;56(6):1293-300.

25.

Exercise in COPD: damned if you do and damned if you don't.

Macklem PT.

Thorax. 2005 Nov;60(11):887-8. No abstract available.

26.

Influence of expiratory flow-limitation during exercise on systemic oxygen delivery in humans.

Aliverti A, Dellacà RL, Lotti P, Bertini S, Duranti R, Scano G, Heyman J, Lo Mauro A, Pedotti A, Macklem PT.

Eur J Appl Physiol. 2005 Oct;95(2-3):229-42. Epub 2005 Aug 5.

PMID:
16086145
27.

Long-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging.

Woods JC, Yablonskiy DA, Choong CK, Chino K, Pierce JA, Hogg JC, Bentley J, Cooper JD, Conradi MS, Macklem PT.

J Appl Physiol (1985). 2005 Nov;99(5):1992-7. Epub 2005 Jul 14.

28.

Complex systems and the technology of variability analysis.

Seely AJ, Macklem PT.

Crit Care. 2004 Dec;8(6):R367-84. Epub 2004 Sep 22. Review.

29.

Cell and molecular biology is not the only way to a better understanding of pathogenesis of lung disease.

Macklem PT.

Am J Respir Crit Care Med. 2004 Jul 1;170(1):ii-iii; author reply iv. No abstract available.

PMID:
15220132
30.

A century of the mechanics of breathing.

Macklem PT.

Am J Respir Crit Care Med. 2004 Jul 1;170(1):10-5. No abstract available.

PMID:
15220122
31.

Detection of expiratory flow limitation in COPD using the forced oscillation technique.

Dellacà RL, Santus P, Aliverti A, Stevenson N, Centanni S, Macklem PT, Pedotti A, Calverley PM.

Eur Respir J. 2004 Feb;23(2):232-40.

32.

Con: Greater funding of cell and molecular biology has not delivered what was promised to respiratory medicine.

Macklem PT.

Am J Respir Crit Care Med. 2004 Feb 15;169(4):438-9; discussion 439-40. No abstract available.

PMID:
14766660
33.

Breath-by-breath assessment of alveolar gas stores and exchange.

Aliverti A, Kayser B, Macklem PT.

J Appl Physiol (1985). 2004 Apr;96(4):1464-9. Epub 2003 Dec 2.

34.

The molecular-clinical divorce.

Macklem PT.

Am J Respir Crit Care Med. 2003 Aug 15;168(4):500. No abstract available.

PMID:
12912736
35.

Airway wall remodeling: friend or foe?

McParland BE, Macklem PT, Pare PD.

J Appl Physiol (1985). 2003 Jul;95(1):426-34. Review.

36.

Effects of rapid saline infusion on lung mechanics and airway responsiveness in humans.

Pellegrino R, Dellaca R, Macklem PT, Aliverti A, Bertini S, Lotti P, Agostoni P, Locatelli A, Brusasco V.

J Appl Physiol (1985). 2003 Aug;95(2):728-34. Epub 2003 May 2.

37.

Is cell and molecular biology divorcing from clinical practice?

Macklem PT.

Am J Respir Crit Care Med. 2003 May 1;167(9):1164-5. No abstract available.

PMID:
12714338
38.

Chest wall kinematic determinants of diaphragm length by optoelectronic plethysmography and ultrasonography.

Aliverti A, Ghidoli G, Dellacà RL, Pedotti A, Macklem PT.

J Appl Physiol (1985). 2003 Feb;94(2):621-30. Epub 2002 Oct 4.

39.

Phonospirometry for noninvasive measurement of ventilation: methodology and preliminary results.

Que CL, Kolmaga C, Durand LG, Kelly SM, Macklem PT.

J Appl Physiol (1985). 2002 Oct;93(4):1515-26.

40.

[A matter of life and death].

Macklem PT.

Rev Mal Respir. 2002 Apr;19(2 Pt1):135-9. French. No abstract available.

PMID:
12040310
41.

Respiratory muscle dynamics and control during exercise with externally imposed expiratory flow limitation.

Aliverti A, Iandelli I, Duranti R, Cala SJ, Kayser B, Kelly S, Misuri G, Pedotti A, Scano G, Sliwinski P, Yan S, Macklem PT.

J Appl Physiol (1985). 2002 May;92(5):1953-63.

42.

Determinants of exercise performance in normal men with externally imposed expiratory flow limitation.

Iandelli I, Aliverti A, Kayser B, Dellacà R, Cala SJ, Duranti R, Kelly S, Scano G, Sliwinski P, Yan S, Macklem PT, Pedotti A.

J Appl Physiol (1985). 2002 May;92(5):1943-52.

43.

Homeokinesis and short-term variability of human airway caliber.

Que CL, Kenyon CM, Olivenstein R, Macklem PT, Maksym GN.

J Appl Physiol (1985). 2001 Sep;91(3):1131-41.

44.

How and why exercise is impaired in COPD.

Aliverti A, Macklem PT.

Respiration. 2001;68(3):229-39. Review.

PMID:
11416240
45.

Respiratory parameters during professional flute playing.

Cossette I, Sliwinski P, Macklem PT.

Respir Physiol. 2000 Jun;121(1):33-44.

PMID:
10854621
46.

Deciphering the homeokinetic code of airway smooth muscle.

Que CL, Maksym G, Macklem PT.

Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 2):S161-3. Review. No abstract available.

PMID:
10712366
47.

Twitch transdiaphragmatic pressure depends critically on thoracoabdominal configuration.

Chen R, Kayser B, Yan S, Macklem PT.

J Appl Physiol (1985). 2000 Jan;88(1):54-60.

48.

Modified Campbell diagram to assess respiratory muscle action in speech.

Johnston S, Yan S, Sliwinski P, Macklem PT.

Respirology. 1999 Sep;4(3):213-22.

PMID:
10489662
49.

Assessment of abdominal muscle contractility, strength, and fatigue.

Suzuki J, Tanaka R, Yan S, Chen R, Macklem PT, Kayser B.

Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1052-60.

PMID:
10194145
50.

Prevalence of exercise induced bronchospasm in Kenyan school children: an urban-rural comparison.

Ng'ang'a LW, Odhiambo JA, Mungai MW, Gicheha CM, Nderitu P, Maingi B, Macklem PT, Becklake MR.

Thorax. 1998 Nov;53(11):919-26. Review.

51.

Urban-rural differences in questionnaire-derived markers of asthma in Kenyan school children.

Odhiambo JA, Ng'ang'a LW, Mungai MW, Gicheha CM, Nyamwaya JK, Karimi F, Macklem PT, Becklake MR.

Eur Respir J. 1998 Nov;12(5):1105-12.

52.

New methods of imaging the respiratory system.

Macklem PT.

Respirology. 1998 Jun;3(2):101-2. No abstract available.

PMID:
9692517
53.

Relationship between airway smooth muscle dysfunction and airway inflammation in asthma.

Macklem PT.

Can Respir J. 1998 Jan-Feb;5(1):40. No abstract available.

PMID:
9556509
54.

The physiology of small airways.

Macklem PT.

Am J Respir Crit Care Med. 1998 May;157(5 Pt 2):S181-3. Review. No abstract available.

PMID:
9606316
55.

Respiratory ultrasonography of human parasternal intercostal muscle in vivo.

Cala SJ, Kenyon CM, Lee A, Watkin K, Macklem PT, Rochester DF.

Ultrasound Med Biol. 1998 Mar;24(3):313-26.

PMID:
9587987
56.

The mechanics of breathing.

Macklem PT.

Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 2):S88-94. No abstract available.

PMID:
9563766
57.

Exercise-induced bronchospasm: a pilot survey in Nairobi school children.

Ng'ang'a LW, Odhiambo JA, Omwega MJ, Gicheha CM, Becklake MR, Menzies R, Mohammed N, Macklem PT.

East Afr Med J. 1997 Nov;74(11):694-8.

PMID:
9557438
58.

Measurement of elastic properties of Xenopus oocytes.

Kelly SM, Jia YL, Macklem PT.

Comp Biochem Physiol A Physiol. 1997 Nov;118(3):607-13.

PMID:
9406437
59.

Human respiratory muscle actions and control during exercise.

Aliverti A, Cala SJ, Duranti R, Ferrigno G, Kenyon CM, Pedotti A, Scano G, Sliwinski P, Macklem PT, Yan S.

J Appl Physiol (1985). 1997 Oct;83(4):1256-69.

60.

Rib cage mechanics during quiet breathing and exercise in humans.

Kenyon CM, Cala SJ, Yan S, Aliverti A, Scano G, Duranti R, Pedotti A, Macklem PT.

J Appl Physiol (1985). 1997 Oct;83(4):1242-55.

61.

Respiratory effort sensation during exercise with induced expiratory-flow limitation in healthy humans.

Kayser B, Sliwinski P, Yan S, Tobiasz M, Macklem PT.

J Appl Physiol (1985). 1997 Sep;83(3):936-47.

62.

Inspiratory muscle dysfunction as a cause of death in COPD patients.

Sliwinski P, Macklem PT.

Monaldi Arch Chest Dis. 1997 Aug;52(4):380-3. Review.

PMID:
9401371
63.

Chest wall and lung volume estimation by optical reflectance motion analysis.

Cala SJ, Kenyon CM, Ferrigno G, Carnevali P, Aliverti A, Pedotti A, Macklem PT, Rochester DF.

J Appl Physiol (1985). 1996 Dec;81(6):2680-9.

64.

Association of chest wall motion and tidal volume responses during CO2 rebreathing.

Yan S, Sliwinski P, Macklem PT.

J Appl Physiol (1985). 1996 Oct;81(4):1528-34.

65.

Science: the broader context.

Macklem PT.

Science. 1996 Aug 30;273(5279):1158b. No abstract available.

PMID:
17842600
66.

Human rib cage distortability.

Chihara K, Kenyon CM, Macklem PT.

J Appl Physiol (1985). 1996 Jul;81(1):437-47.

PMID:
8828696
67.

Can airway function be predicted?

Macklem PT.

Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 2):S19-20. Review. No abstract available.

PMID:
8646376
68.

Influence of global inspiratory muscle fatigue on breathing during exercise.

Sliwiński P, Yan S, Gauthier AP, Macklem PT.

J Appl Physiol (1985). 1996 Apr;80(4):1270-8.

PMID:
8926256
69.

Respirology.

Macklem PT.

Respirology. 1996 Mar;1(1):4. No abstract available.

PMID:
9432404
70.

Nutritional status and mortality in chronic obstructive pulmonary disease.

Gray-Donald K, Gibbons L, Shapiro SH, Macklem PT, Martin JG.

Am J Respir Crit Care Med. 1996 Mar;153(3):961-6.

PMID:
8630580
71.

Detection of excessive bronchoconstriction in asthma.

Gibbons WJ, Sharma A, Lougheed D, Macklem PT.

Am J Respir Crit Care Med. 1996 Feb;153(2):582-9.

PMID:
8564102
72.

[Effect of respiratory muscle fatigue on their function during exercise].

Sliwiński P, Yan S, Gauthier AP, Macklem PT.

Pneumonol Alergol Pol. 1996;64(9-10):590-603. Polish.

PMID:
8991554
73.

[Function of the diaphragm during exercise].

Sliwiński P, Yan S, Gauthier AP, Macklem PT.

Pneumonol Alergol Pol. 1996;64(9-10):577-89. Polish.

PMID:
8991553
74.

Invited editorial on "airflow effects on amplitude and spectral content of normal breath sounds".

Macklem PT.

J Appl Physiol (1985). 1996 Jan;80(1):3-4. No abstract available.

PMID:
8847319
75.

Intracellular pressure is a motive force for cell motion in Amoeba proteus.

Yanai M, Kenyon CM, Butler JP, Macklem PT, Kelly SM.

Cell Motil Cytoskeleton. 1996;33(1):22-9.

PMID:
8824731
76.

A theoretical analysis of the effect of airway smooth muscle load on airway narrowing.

Macklem PT.

Am J Respir Crit Care Med. 1996 Jan;153(1):83-9.

PMID:
8542167
77.

Control of cell volume in oocytes and eggs from Xenopus laevis.

Kelly SM, Butler JP, Macklem PT.

Comp Biochem Physiol A Physiol. 1995 Aug;111(4):681-91.

PMID:
7671156
78.

Effects of fatigue, fiber length, and aminophylline on human diaphragm contractility.

Gauthier AP, Yan S, Sliwinski P, Macklem PT.

Am J Respir Crit Care Med. 1995 Jul;152(1):204-10.

PMID:
7599825
79.

Density dependence of pulmonary resistance: correlation with small airway pathology.

Guillemi S, Wright JL, Hogg JC, Wiggs BR, Macklem PT, Paré PD.

Eur Respir J. 1995 May;8(5):789-94.

80.

Theoretical basis of airway instability. Roger S. Mitchell Lecture.

Macklem PT.

Chest. 1995 Mar;107(3 Suppl):87S-88S. No abstract available.

PMID:
7875009
81.

Three-dimensional reconstruction of the in vivo human diaphragm shape at different lung volumes.

Gauthier AP, Verbanck S, Estenne M, Segebarth C, Macklem PT, Paiva M.

J Appl Physiol (1985). 1994 Feb;76(2):495-506.

PMID:
8175555
82.

Effect of diaphragmatic and global inspiratory muscle fatigue on chemical control of breathing.

Yan S, Macklem PT.

Monaldi Arch Chest Dis. 1993 Oct;48(5):386-8. No abstract available.

PMID:
8312885
83.

Effect of global inspiratory muscle fatigue on ventilatory and respiratory muscle responses to CO2.

Yan S, Sliwinski P, Gauthier AP, Lichros I, Zakynthinos S, Macklem PT.

J Appl Physiol (1985). 1993 Sep;75(3):1371-7.

PMID:
8226553
84.

Effect of diaphragmatic fatigue on control of respiratory muscles and ventilation during CO2 rebreathing.

Yan S, Lichros I, Zakynthinos S, Macklem PT.

J Appl Physiol (1985). 1993 Sep;75(3):1364-70.

PMID:
8226552
85.

Lung volume changes during relatively fluent speech in stutterers.

Johnston SJ, Watkin KL, Macklem PT.

J Appl Physiol (1985). 1993 Aug;75(2):696-703.

PMID:
8226471
86.

Assessment of diaphragm function using mouth pressure twitches in chronic obstructive pulmonary disease patients.

Similowski T, Gauthier AP, Yan S, Macklem PT, Bellemare F.

Am Rev Respir Dis. 1993 Apr;147(4):850-6.

PMID:
8466119
87.

Force-frequency relationships of in vivo human and in vitro rat diaphragm using paired stimuli.

Yan S, Gauthier AP, Similowski T, Faltus R, Macklem PT, Bellemare F.

Eur Respir J. 1993 Feb;6(2):211-8.

PMID:
8444292
88.

Effects of fatigue on the length-tetanic force relationship of the rat diaphragm.

Gauthier AP, Faltus RE, Macklem PT, Bellemare F.

J Appl Physiol (1985). 1993 Jan;74(1):326-32.

PMID:
8444710
89.

Effect of negative pressure ventilation in severe chronic obstructive pulmonary disease.

Shapiro SH, Ernst P, Gray-Donald K, Martin JG, Wood-Dauphinee S, Beaupré A, Spitzer WO, Macklem PT.

Lancet. 1992 Dec 12;340(8833):1425-9.

PMID:
1360558
90.

Effect of lung volume on plateau response of airways and tissue to methacholine in dogs.

Robatto FM, Simard S, Orana H, Macklem PT, Ludwig MS.

J Appl Physiol (1985). 1992 Nov;73(5):1908-13.

PMID:
1474068
91.

Induction of sleep apnoea with negative pressure ventilation in patients with chronic obstructive lung disease.

Levy RD, Cosio MG, Gibbons L, Macklem PT, Martin JG.

Thorax. 1992 Aug;47(8):612-5.

92.

The influence of governmental decision-making on academic medicine: Part II.

Macklem PT.

Clin Invest Med. 1992 Jun;15(3):276-81. No abstract available.

PMID:
1638807
93.

Evaluation of human diaphragm contractility using mouth pressure twitches.

Yan S, Gauthier AP, Similowski T, Macklem PT, Bellemare F.

Am Rev Respir Dis. 1992 May;145(5):1064-9.

PMID:
1586048
94.

Mechanical implications of in vivo human diaphragm shape.

Paiva M, Verbanck S, Estenne M, Poncelet B, Segebarth C, Macklem PT.

J Appl Physiol (1985). 1992 Apr;72(4):1407-12.

PMID:
1592732
95.

Analysis of human chest wall motion using a two-compartment rib cage model.

Ward ME, Ward JW, Macklem PT.

J Appl Physiol (1985). 1992 Apr;72(4):1338-47.

PMID:
1592724
96.

Effect of fatigue on diaphragmatic function at different lung volumes.

Yan S, Similowski T, Gauthier AP, Macklem PT, Bellemare F.

J Appl Physiol (1985). 1992 Mar;72(3):1064-7.

PMID:
1568961
97.

Vector analysis in partitioning of inspiratory muscle action in dogs.

Ward ME, Paiva M, Macklem PT.

Eur Respir J. 1992 Feb;5(2):219-27.

PMID:
1559587
98.

Contractile properties of the human diaphragm during chronic hyperinflation.

Similowski T, Yan S, Gauthier AP, Macklem PT, Bellemare F.

N Engl J Med. 1991 Sep 26;325(13):917-23.

99.

Factors determining bronchial smooth muscle shortening.

Macklem PT.

Am Rev Respir Dis. 1991 Mar;143(3 Pt 2):S47-8. No abstract available.

PMID:
2003689
100.

Direct measurement of intracellular pressure.

Kelly SM, Macklem PT.

Am J Physiol. 1991 Mar;260(3 Pt 1):C652-7.

PMID:
2003586
101.

A randomized clinical trial of negative pressure ventilation in severe chronic obstructive pulmonary disease: design and methods.

Shapiro SH, Macklem PT, Gray-Donald K, Martin JG, Ernst PP, Wood-Dauphinee S, Hutchinson TA, Spitzer WO.

J Clin Epidemiol. 1991;44(6):483-96.

PMID:
2037853
102.

The importance of defining respiratory muscle fatigue.

Macklem PT.

Am Rev Respir Dis. 1990 Aug;142(2):274. No abstract available.

PMID:
2382889
103.
104.

Respiratory muscle incoordination in stuttering speech.

Zocchi L, Estenne M, Johnston S, Del Ferro L, Ward ME, Macklem PT.

Am Rev Respir Dis. 1990 Jun;141(6):1510-5.

PMID:
2350093
105.

Chest wall motion and expiratory muscle use during phonation in normal humans.

Estenne M, Zocchi L, Ward M, Macklem PT.

J Appl Physiol (1985). 1990 May;68(5):2075-82.

PMID:
2361909
106.

Peripheral bronchographic morphology in the normal human lung 1971.

Gamsu G, Thurlbeck WM, Macklem PT, Fraser RG.

Invest Radiol. 1990 Apr;25(4):392-401. No abstract available.

PMID:
2185190
107.

The act of breathing and how it fails.

Ward M, Macklem PT.

Chest. 1990 Mar;97(3 Suppl):36S-39S. Review. No abstract available.

PMID:
2407460
108.

A hypothesis linking bronchial hyperreactivity and airway inflammation: implications for therapy.

Macklem PT.

Ann Allergy. 1990 Feb;64(2 Pt 1):113-6. Review. No abstract available.

PMID:
2407159
109.

Reexamination of the elastic properties of emphysematous lungs.

Macklem PT, Eidelman D.

Respiration. 1990;57(3):187-92.

PMID:
2274717
110.

Lung border sweep upon phrenic stimulation: dynamic fall in pleural liquid pressure.

Agostoni E, Zocchi L, Macklem PT.

Respir Physiol. 1989 Sep;77(3):379-94.

PMID:
2781172
111.

Risk factors and prevention strategies for asthma.

Macklem PT.

Chest. 1989 Sep;96(3 Suppl):361S-362S. No abstract available.

PMID:
2766854
112.

Mechanical factors determining maximum bronchoconstriction.

Macklem PT.

Eur Respir J Suppl. 1989 Jun;6:516s-519s.

PMID:
2803407
113.

Effects of elastase-induced emphysema on airway responsiveness to methacholine in rats.

Bellofiore S, Eidelman DH, Macklem PT, Martin JG.

J Appl Physiol (1985). 1989 Feb;66(2):606-12.

PMID:
2651383
114.

Negative pressure ventilation. Effects on ventilation during sleep in normal subjects.

Levy RD, Bradley TD, Newman SL, Macklem PT, Martin JG.

Chest. 1989 Jan;95(1):95-9.

PMID:
2909361
115.

Pleural pressure from abdominal to pulmonary rib cage: sweep of the lung border.

Agostoni E, Zocchi L, Agostoni PG, Macklem PT.

Respir Physiol. 1989 Jan;75(1):105-15.

PMID:
2717809
116.

The control of cell volume: frog eggs face an extreme challenge.

Macklem PT, Kelly S.

Trans Am Clin Climatol Assoc. 1990;101:114-20; discussion 120-1. No abstract available.

117.

Respiratory sensation and pattern of respiratory muscle activation during diaphragm fatigue.

Ward ME, Eidelman D, Stubbing DG, Bellemare F, Macklem PT.

J Appl Physiol (1985). 1988 Nov;65(5):2181-9.

PMID:
3209561
118.

Transdiaphragmatic pressure and rib motion in area of apposition during paralysis.

Agostoni E, Zocchi L, Macklem PT.

J Appl Physiol (1985). 1988 Sep;65(3):1296-300.

PMID:
3182499
119.

Pleural pressure between diaphragm and rib cage during inspiratory muscle activity.

Macklem PT, Zocchi L, Agostoni E.

J Appl Physiol (1985). 1988 Sep;65(3):1286-95.

PMID:
3182498
120.

Optimization of respiratory muscle relaxation during mechanical ventilation.

Ward ME, Corbeil C, Gibbons W, Newman S, Macklem PT.

Anesthesiology. 1988 Jul;69(1):29-35.

PMID:
3389564
121.

Clinical assessment of the respiratory muscles.

Macklem PT.

Pneumonol Pol. 1988 Jun;56(6):249-53. No abstract available.

PMID:
3226941
122.

Effect of lung volume on interrupter resistance in cats challenged with methacholine.

Sly PD, Brown KA, Bates JH, Macklem PT, Milic-Emili J, Martin JG.

J Appl Physiol (1985). 1988 Jan;64(1):360-6.

PMID:
3281928
123.

Bronchial hyporesponsiveness.

Macklem PT.

Chest. 1987 Jun;91(6 Suppl):189S-191S.

PMID:
3581958
124.

Effect of hyperinflation and equalization of abdominal pressure on diaphragmatic action.

Zocchi L, Garzaniti N, Newman S, Macklem PT.

J Appl Physiol (1985). 1987 Apr;62(4):1655-64.

PMID:
3597237
125.

Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans.

Ding DJ, Martin JG, Macklem PT.

J Appl Physiol (1985). 1987 Mar;62(3):1324-30.

PMID:
3553143
126.

(T)he(o)retical ideas of diaphragmatic action.

Macklem PT.

Clin Invest Med. 1987 Jan;10(1):21-5.

PMID:
3815931
127.

Airway responses to aerosolized methacholine in the cat. Effects of partial or complete vagosympathectomy.

Bai TR, Macklem PT, Martin JG.

Am Rev Respir Dis. 1987 Jan;135(1):190-3.

PMID:
3541716
128.

Relationship between diaphragm length and abdominal dimensions.

Decramer M, Xi JT, Reid MB, Kelly S, Macklem PT, Demedts M.

J Appl Physiol (1985). 1986 Nov;61(5):1815-20.

PMID:
3781990
129.

The clinical relevance of respiratory muscle research. J. Burns Amberson lecture.

Macklem PT.

Am Rev Respir Dis. 1986 Oct;134(4):812-5. No abstract available.

PMID:
2945504
130.

Muscular weakness and respiratory function.

Macklem PT.

N Engl J Med. 1986 Mar 20;314(12):775-6. No abstract available.

PMID:
3951507
131.

Respiratory muscle dysfunction.

Macklem PT.

Hosp Pract (Off Ed). 1986 Mar 15;21(3):83-90, 95-6. No abstract available.

PMID:
3081555
132.

The effects of parasympathectomy on serotonin-induced bronchoconstriction in the cat.

Bai TR, Macklem PT, Martin JG.

Am Rev Respir Dis. 1986 Jan;133(1):110-5.

PMID:
3942367
133.

Ventilatory muscle function during exercise in air and oxygen in patients with chronic air-flow limitation.

Bye PT, Esau SA, Levy RD, Shiner RJ, Macklem PT, Martin JG, Pardy RL.

Am Rev Respir Dis. 1985 Aug;132(2):236-40.

PMID:
4026048
134.

Effects of separate rib cage and abdominal restriction on exercise performance in normal humans.

Hussain SN, Rabinovitch B, Macklem PT, Pardy RL.

J Appl Physiol (1985). 1985 Jun;58(6):2020-6.

PMID:
3159716
135.

Mechanics of intercostal space and actions of external and internal intercostal muscles.

De Troyer A, Kelly S, Macklem PT, Zin WA.

J Clin Invest. 1985 Mar;75(3):850-7.

136.

The assessment of diaphragmatic contractility.

Macklem PT.

Anesthesiology. 1985 Mar;62(3):229-30. No abstract available.

PMID:
3977109
137.

Trouble in academe.

Macklem PT.

Clin Invest Med. 1985;8(1):85-8. No abstract available.

PMID:
3987122
138.

Regional differences in abdominal pressure swings in dogs.

Decramer M, De Troyer A, Kelly S, Zocchi L, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1984 Dec;57(6):1682-7.

PMID:
6511543
139.

Inspiratory muscle strength and body composition in patients receiving total parenteral nutrition therapy.

Kelly SM, Rosa A, Field S, Coughlin M, Shizgal HM, Macklem PT.

Am Rev Respir Dis. 1984 Jul;130(1):33-7.

PMID:
6430137
140.

Mechanical arrangement of costal and crural diaphragms in dogs.

Decramer M, De Troyer A, Kelly S, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1984 Jun;56(6):1484-90.

PMID:
6735807
141.

The ventilatory pump in exercise.

Pardy RL, Hussain SN, Macklem PT.

Clin Chest Med. 1984 Mar;5(1):35-49.

PMID:
6233083
142.

Ventilatory muscles during exercise in air and oxygen in normal men.

Bye PT, Esau SA, Walley KR, Macklem PT, Pardy RL.

J Appl Physiol Respir Environ Exerc Physiol. 1984 Feb;56(2):464-71.

PMID:
6706758
143.

Dyspnea, fatigue, and second wind.

Scharf S, Bye P, Pardy R, Macklem PT.

Am Rev Respir Dis. 1984 Feb;129(2 Pt 2):S88-9. No abstract available.

PMID:
6696350
144.

"Second wind" during inspiratory loading.

Scharf SM, Bark H, Heimer D, Cohen A, Macklem PT.

Med Sci Sports Exerc. 1984;16(1):87-91.

PMID:
6708787
145.

Hyperinflation.

Macklem PT.

Am Rev Respir Dis. 1984 Jan;129(1):1-2. No abstract available.

PMID:
6703469
146.

Medicare in Canada: a biased view.

Macklem PT.

Clin Invest Med. 1984;7(3):133-4. No abstract available.

PMID:
6518680
147.

Respiratory muscle fatigue and ventilatory failure.

Grassino A, Macklem PT.

Annu Rev Med. 1984;35:625-47. Review.

PMID:
6372673
148.

The geometry of the microvascular bed of the diaphragm: comparison to intercostals and triceps.

Schraufnagel DE, Roussos C, Macklem PT, Wang NS.

Microvasc Res. 1983 Nov;26(3):291-306.

PMID:
6656665
149.

A model of inspiratory muscle mechanics.

Macklem PT, Macklem DM, De Troyer A.

J Appl Physiol Respir Environ Exerc Physiol. 1983 Aug;55(2):547-57.

PMID:
6618947
150.

Effect of caffeine on skeletal muscle function before and after fatigue.

Lopes JM, Aubier M, Jardim J, Aranda JV, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1983 May;54(5):1303-5.

PMID:
6863091
151.

Radiology of the diaphragm as two muscles.

Stewart ME, Hanson RE, De Troyer A, Macklem PT.

Invest Radiol. 1983 Mar-Apr;18(2):155-9.

PMID:
6862807
152.

[Relationship between reduced pulmonary elasticity in smokers and peripheral airway obstruction and pulmonary emphysema].

Macklem PT.

Kokyu To Junkan. 1983 Feb;31(2):118-26. Japanese. No abstract available.

PMID:
6867481
153.

Non-adrenergic inhibitory nerves.

Irvin C, Martin R, Macklem PT.

Eur J Respir Dis Suppl. 1983;128 (Pt 1):133-8. No abstract available.

PMID:
6578064
154.

Changes in EMG power spectrum (high-to-low ratio) with force fatigue in humans.

Moxham J, Edwards RH, Aubier M, De Troyer A, Farkas G, Macklem PT, Roussos C.

J Appl Physiol Respir Environ Exerc Physiol. 1982 Nov;53(5):1094-9.

PMID:
7174404
155.

The effects of inspiratory muscle training in patients with cystic fibrosis.

Asher MI, Pardy RL, Coates AL, Thomas E, Macklem PT.

Am Rev Respir Dis. 1982 Nov;126(5):855-9.

PMID:
7149451
156.

The respiratory muscles.

Roussos C, Macklem PT.

N Engl J Med. 1982 Sep 23;307(13):786-97. Review. No abstract available.

PMID:
7050712
157.

Correlation of regional breath sound with regional ventilation in emphysema.

Ploysongsang Y, Paré JA, Macklem PT.

Am Rev Respir Dis. 1982 Sep;126(3):526-9.

PMID:
7125339
158.

Clinical manifestations of inspiratory muscle fatigue.

Cohen CA, Zagelbaum G, Gross D, Roussos C, Macklem PT.

Am J Med. 1982 Sep;73(3):308-16.

PMID:
6812417
159.

Action of costal and crural parts of the diaphragm on the rib cage in dog.

De Troyer A, Sampson M, Sigrist S, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul;53(1):30-9.

PMID:
7118646
160.

The oxygen cost of breathing in patients with cardiorespiratory disease.

Field S, Kelly SM, Macklem PT.

Am Rev Respir Dis. 1982 Jul;126(1):9-13.

PMID:
7091914
161.

The diaphragm in health and disease.

Macklem PT.

J Lab Clin Med. 1982 May;99(5):601-10.

PMID:
7069265
162.

Nonpurinergic nature and efficacy of nonadrenergic bronchodilation.

Irvin CG, Martin RR, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1982 Mar;52(3):562-9.

PMID:
6121785
163.

The failing inspiratory muscles under normoxic and hypoxic conditions.

Jardim J, Farkas G, Prefaut C, Thomas D, Macklem PT, Roussos C.

Am Rev Respir Dis. 1981 Sep;124(3):274-9.

PMID:
7283260
164.

Aminophylline improves diaphragmatic contractility.

Aubier M, De Troyer A, Sampson M, Macklem PT, Roussos C.

N Engl J Med. 1981 Jul 30;305(5):249-52.

PMID:
7242614
165.

The diaphragm: two muscles.

De Troyer A, Sampson M, Sigrist S, Macklem PT.

Science. 1981 Jul 10;213(4504):237-8.

PMID:
7244632
166.

Weight loss, weakness and an abnormal roentgenogram of the chest in a 72-year-old woman.

Macklem PT, Sheldon H.

Can Med Assoc J. 1981 Jul 1;125(1):30-6. No abstract available.

167.

Lung sounds in patients with emphysema.

Ploysongsang Y, Pare JA, Macklem PT.

Am Rev Respir Dis. 1981 Jul;124(1):45-9.

PMID:
7258819
168.

The effects of inspiratory muscle training on exercise performance in chronic airflow limitation.

Pardy RL, Rivington RN, Despas PJ, Macklem PT.

Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):426-33.

PMID:
7224355
169.

Inspiratory muscle training compared with physiotherapy in patients with chronic airflow limitation.

Pardy RL, Rivington RN, Despas PJ, Macklem PT.

Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):421-5.

PMID:
7224354
170.

Normal and abnormal function of the diaphragm.

Macklem PT.

Thorax. 1981 Mar;36(3):161-3. No abstract available.

171.

[Small airways disease (author's transl)].

Préfaut C, Macklem PT.

Rev Fr Mal Respir. 1981;9(6):433-44. Review. French.

PMID:
7036267
172.

The pathophysiology of inspiratory muscle fatigue.

Macklem PT, Cohen C, Zagelbaum G, Roussos C.

Ciba Found Symp. 1981;82:249-63.

PMID:
6913474
173.

Respiratory muscles: the vital pump.

Macklem PT.

Chest. 1980 Nov;78(5):753-8. No abstract available.

PMID:
7428459
174.

The paradoxical nature of pulmonary pressure-flow relationships.

Macklem PT.

Fed Proc. 1980 Aug;39(10):2755-8.

PMID:
7409200
175.

Is extrathoracic airway obstruction important in asthma?

Lisboa C, Jardim J, Angus E, Macklem PT.

Am Rev Respir Dis. 1980 Jul;122(1):115-21. No abstract available.

PMID:
7406332
176.

Inspiratory muscle fatigue and acute respiratory failure.

Roussos C, Grassino A, Macklem PT.

Can Med Assoc J. 1980 Jun 21;122(12):1375-7. No abstract available.

177.

Relation between flow, curvilinearity, and density dependence of pulmonary pressure-flow curves.

Lisboa C, Wood LD, Jardim J, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1980 May;48(5):878-85.

PMID:
7451298
178.

Bronchodilatation: noncholinergic, nonadrenergic mediation demonstrated in vivo in the cat.

Irvin CG, Boileau R, Tremblay J, Martin RR, Macklem PT.

Science. 1980 Feb 15;207(4432):791-2.

PMID:
7352292
179.

The effect of training on strength and endurance of the diaphragm in quadriplegia.

Gross D, Ladd HW, Riley EJ, Macklem PT, Grassino A.

Am J Med. 1980 Jan;68(1):27-35.

PMID:
7350802
180.

A mathematical and graphical analysis of inspiratory muscle action.

Macklem PT.

Respir Physiol. 1979 Oct;38(2):153-71.

PMID:
504828
181.

The interaction between the diaphragm, intercostal/accessory muscles of inspiration and the rib cage.

Macklem PT, Roussos C, Derenne JP, Delhez L.

Respir Physiol. 1979 Oct;38(2):141-52.

PMID:
504827
182.

Pulmonary pressure-flow curves measured by a data-averaging circuit.

Lisboa C, Ross WR, Jardim J, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1979 Sep;47(3):621-7.

PMID:
533757
183.

Measurement of the distensibility of the parabronchi in duck lungs.

Macklem PT, Bouverot P, Scheid P.

Respir Physiol. 1979 Sep;38(1):23-35.

PMID:
515560
184.

Influence of immersion to the neck in water on airway closure and distribution of perfusion in man.

Prefaut C, Dubois F, Roussos C, Amaral-Marques R, Macklem PT, Ruff F.

Respir Physiol. 1979 Aug;37(3):313-23.

PMID:
493752
185.

Relationship between the single-breath N test and age, sex, and smoking habit in three North American cities.

Buist AS, Ghezzo H, Anthonisen NR, Cherniack RM, Ducic S, Macklem PT, Manfreda J, Martin RR, McCarthy D, Ross BB.

Am Rev Respir Dis. 1979 Aug;120(2):305-18.

PMID:
475152
186.

A four-year follow-up study of lung mechanics in smokers.

Corbin RP, Loveland M, Martin RR, Macklem PT.

Am Rev Respir Dis. 1979 Aug;120(2):293-304.

PMID:
475151
187.

Fatigue of inspiratory muscles and their synergic behavior.

Roussos C, Fixley M, Gross D, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1979 May;46(5):897-904.

PMID:
468606
188.

Effect of pentobarbital anesthesia on rheology and transport of canine tracheal mucus.

King M, Engel LA, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):504-9.

PMID:
438019
189.

Diaphragmatic fatigue [proceedings].

Macklem PT, Roussos C, Gross D, Ladd H, Riley E, Grassino A, Jardim J, Plante F.

Am Rev Respir Dis. 1979 Feb;119(2 Pt 2):93. No abstract available.

PMID:
426363
190.

Demonstration of regional phase differences in ventilation by breath sounds.

Ploy-Song-Sang Y, Dosman J, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1979 Feb;46(2):361-8.

PMID:
422453
191.

Rib cage-diaphragm interaction. Montreal view.

Macklem PT.

Am Rev Respir Dis. 1979 Feb;119(2 Pt 2):27-9. No abstract available.

PMID:
154867
192.

Inspiratory muscle fatigue as a factor limiting exercise.

Grassino A, Gross D, Macklem PT, Roussos C, Zagelbaum G.

Bull Eur Physiopathol Respir. 1979 Jan-Feb;15(1):105-15. No abstract available.

PMID:
465811
193.

Electromyogram pattern of diaphragmatic fatigue.

Gross D, Grassino A, Ross WR, Macklem PT.

J Appl Physiol Respir Environ Exerc Physiol. 1979 Jan;46(1):1-7.

PMID:
457515
194.

Smooth muscle constriction and mechanisms of gas trapping.

Amyot R, Sergysels R, Delaunois L, Boileau R, Macklem PT, Martin RR.

Scand J Respir Dis Suppl. 1979;103:19-24. No abstract available.

PMID:
285464
195.

[Initiatives which the IUAT could take regarding smoking].

Woolcock AJ, Macklem PT.

Bull Int Union Tuberc. 1978 Dec;53(4):359-62. French. No abstract available.

PMID:
756314
196.

Is screening for chronic limitation of airflow desirable.

Macklem PT, Becklake MR.

Chest. 1978 Dec;74(6):607-8. No abstract available.

PMID:
738114
197.

[Physiopathology of the limitation of airflow].

Macklem PT.

Bull Int Union Tuberc. 1978 Sep;53(3):167-71. French. No abstract available.

PMID:
719208
198.

The respiratory muscles: mechanics, control, and pathophysiology. Part III.

Derenne JP, Macklem PT, Roussos C.

Am Rev Respir Dis. 1978 Sep;118(3):581-601. Review. No abstract available.

PMID:
360894
199.

The respiratory muscles: Mechanics, control, and pathophysiology. Part 2.

Derenne JP, Macklem PT, Roussos C.

Am Rev Respir Dis. 1978 Aug;118(2):373-90. Review. No abstract available.

PMID:
358878
200.

The respiratory muscles: mechanics, control, and pathophysiology.

Derenne JP, Macklem PT, Roussos C.

Am Rev Respir Dis. 1978 Jul;118(1):119-33. Review. No abstract available.

PMID:
150242

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