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Items: 1 to 20 of 3408

1.

Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer.

Elie J, Vercouillie J, Arlicot N, Lemaire L, Bidault R, Bodard S, Hosselet C, Deloye JB, Chalon S, Emond P, Guilloteau D, Buron F, Routier S.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1-7. doi: 10.1080/14756366.2018.1501043.

2.

Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking.

El-Husseiny WM, El-Sayed MA, Abdel-Aziz NI, El-Azab AS, Asiri YA, Abdel-Aziz AA.

Eur J Med Chem. 2018 Oct 5;158:134-143. doi: 10.1016/j.ejmech.2018.09.007. Epub 2018 Sep 5.

PMID:
30216848
3.

Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy.

Ren SZ, Wang ZC, Zhu D, Zhu XH, Shen FQ, Wu SY, Chen JJ, Xu C, Zhu HL.

Eur J Med Chem. 2018 Sep 5;157:909-924. doi: 10.1016/j.ejmech.2018.08.048. Epub 2018 Aug 22.

PMID:
30149323
4.

Selective COX-2 inhibitor versus non-selective COX-2 inhibitor for the prevention of heterotopic ossification after total hip arthroplasty: A meta-analysis.

Zhu XT, Chen L, Lin JH.

Medicine (Baltimore). 2018 Aug;97(31):e11649. doi: 10.1097/MD.0000000000011649. Review.

5.

Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer.

Shimizu K, Okita R, Saisho S, Maeda AI, Nojima Y, Nakata M.

Anticancer Res. 2018 Aug;38(8):4637-4644. doi: 10.21873/anticanres.12768.

PMID:
30061230
6.

COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs.

Aisa MC, Datti A, Orlacchio A, Di Renzo GC.

Life Sci. 2018 Sep 1;208:10-19. doi: 10.1016/j.lfs.2018.07.011. Epub 2018 Jul 7.

PMID:
29990484
7.

Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities.

Qin FY, Yan YM, Tu ZC, Cheng YX.

Fitoterapia. 2018 Sep;129:167-172. doi: 10.1016/j.fitote.2018.06.019. Epub 2018 Jun 30.

PMID:
29969649
8.

Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity.

Lv JL, Zhang LB, Guo LM.

Fitoterapia. 2018 Sep;129:102-107. doi: 10.1016/j.fitote.2018.06.016. Epub 2018 Jun 21.

PMID:
29935258
9.

Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.

Merlos M, Portillo-Salido E, Brenchat A, Aubel B, Buxens J, Fisas A, Codony X, Romero L, Zamanillo D, Vela JM.

Eur J Pharmacol. 2018 Aug 15;833:370-378. doi: 10.1016/j.ejphar.2018.06.022. Epub 2018 Jun 19.

10.

Regulating the Golgi apparatus by co-delivery of a COX-2 inhibitor and Brefeldin A for suppression of tumor metastasis.

Yu RY, Xing L, Cui PF, Qiao JB, He YJ, Chang X, Zhou TJ, Jin QR, Jiang HL, Xiao Y.

Biomater Sci. 2018 Jul 24;6(8):2144-2155. doi: 10.1039/c8bm00381e.

PMID:
29923556
11.

Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum.

Ahmed AF, Chen YW, Huang CY, Tseng YJ, Lin CC, Dai CF, Wu YC, Sheu JH.

Mar Drugs. 2018 Jun 14;16(6). pii: E210. doi: 10.3390/md16060210.

12.

Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies.

Bhat MA, Al-Omar MA, Raish M, Ansari MA, Abuelizz HA, Bakheit AH, Naglah AM.

Molecules. 2018 May 24;23(6). pii: E1250. doi: 10.3390/molecules23061250.

13.

Synthesis and amelioration of inflammatory paw edema by novel benzophenone appended oxadiazole derivatives by exhibiting cyclooxygenase-2 antagonist activity.

Puttaswamy N, Malojiao VH, Mohammed YHE, Sherapura A, Prabhakar BT, Khanum SA.

Biomed Pharmacother. 2018 Jul;103:1446-1455. doi: 10.1016/j.biopha.2018.04.167. Epub 2018 May 7.

PMID:
29864929
14.

Indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 expression prediction for adverse prognosis in colorectal cancer.

Ma WJ, Wang X, Yan WT, Zhou ZG, Pan ZZ, Chen G, Zhang RX.

World J Gastroenterol. 2018 May 28;24(20):2181-2190. doi: 10.3748/wjg.v24.i20.2181.

15.

Design, Synthesis and In-vivo Anti-inflammatory Activity of New Celecoxib Analogues as NSAID.

Abdel Hafez NA, Ali KA, Ibrahim AA, Elnaggar DH, Sleem AA.

Mini Rev Med Chem. 2018;18(16):1398-1408. doi: 10.2174/1389557518666180530124509.

PMID:
29848275
16.

Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice.

Jin X, Zhou F, Liu Y, Cheng C, Yao L, Jia Y, Wang G, Zhang J.

J Pharm Biomed Anal. 2018 Sep 5;158:1-7. doi: 10.1016/j.jpba.2018.05.034. Epub 2018 May 22.

PMID:
29843006
17.

Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies.

El-Azab AS, Abdel-Aziz AA, Abou-Zeid LA, El-Husseiny WM, El Morsy AM, El-Gendy MA, El-Sayed MA.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):989-998. doi: 10.1080/14756366.2018.1474878.

18.

Design, Synthesis and Biological Evaluation of New 1,3-diphenyl-3- (phenylamino)propan-1-ones as Selective Cyclooxygenase (COX-2) Inhibitors.

Farzaneh S, Shahhosseini S, Arefi H, Daraei B, Esfahanizadeh M, Zarghi A.

Med Chem. 2018;14(7):652-659. doi: 10.2174/1573406414666180525133221.

PMID:
29804536
19.

Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents.

Kaur A, Pathak DP, Sharma V, Wakode S.

Arch Pharm (Weinheim). 2018 Jun;351(6):e1800008. doi: 10.1002/ardp.201800008. Epub 2018 May 9.

PMID:
29741797
20.

Silver-choline chloride modified graphene oxide: Novel nano-bioelectrochemical sensor for celecoxib detection and CCD-RSM model.

Parsaee Z, Karachi N, Abrishamifar SM, Kahkha MRR, Razavi R.

Ultrason Sonochem. 2018 Jul;45:106-115. doi: 10.1016/j.ultsonch.2018.03.009. Epub 2018 Mar 17.

PMID:
29705303

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