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J Gen Virol. 2018 Apr;99(4):549-557. doi: 10.1099/jgv.0.001028. Epub 2018 Feb 22.

Diverse papillomaviruses identified in Weddell seals.

Author information

1
1​The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, AZ 85287-5001, USA.
2
2​School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
3
3​Department of Biological Sciences, University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA.
4
4​School of Animal and Comparative Biomedical Sciences, Cancer Biology Graduate Interdisciplinary Program, Genetics Graduate Interdisciplinary Program, and Bio5, University of Arizona, 1657 E Helen St., Tucson, AZ 85721, USA.
5
5​Department of Biology and Wildlife, University of Alaska Fairbanks, PO Box 756100, Fairbanks, AK 99775, USA.
6
6​College of Fisheries and Ocean Sciences, University of Alaska Fairbanks, 17101 Point Lena Loop Rd Juneau, Alaska 99801, USA.
7
7​Bridge Veterinary Services, LLC, Juneau, AK 99801, USA.
8
8​Structural Biology Research Unit, Department of Clinical Laboratory Sciences, University of Cape Town, Rondebosch, 7701, Cape Town, South Africa.

Abstract

Papillomaviridae is a diverse family of circular, double-stranded DNA (dsDNA) viruses that infect a broad range of mammalian, avian and fish hosts. While papillomaviruses have been characterized most extensively in humans, the study of non-human papillomaviruses has contributed greatly to our understanding of their pathogenicity and evolution. Using high-throughput sequencing approaches, we identified 7 novel papillomaviruses from vaginal swabs collected from 81 adult female Weddell seals (Leptonychotes weddellii) in the Ross Sea of Antarctica between 2014-2017. These seven papillomavirus genomes were amplified from seven individual seals, and six of the seven genomes represented novel species with distinct evolutionary lineages. This highlights the diversity of papillomaviruses among the relatively small number of Weddell seal samples tested. Viruses associated with large vertebrates are poorly studied in Antarctica, and this study adds information about papillomaviruses associated with Weddell seals and contributes to our understanding of the evolutionary history of papillomaviruses.

KEYWORDS:

Antarctic; Carnivora; Leptonychotes weddellii; papillomavirus

PMID:
29469687
PMCID:
PMC5982131
[Available on 2019-04-01]
DOI:
10.1099/jgv.0.001028

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