Format

Send to

Choose Destination
PLoS Pathog. 2016 Apr 19;12(4):e1005574. doi: 10.1371/journal.ppat.1005574. eCollection 2016 Apr.

The Ancient Evolutionary History of Polyomaviruses.

Author information

1
Lab of Cellular Oncology, NCI, NIH, Bethesda, Maryland, United States of America.
2
Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, United States of America.
3
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
4
Department of Pathology, University of Georgia, Athens, Georgia, United States of America.
5
Animal Health Department, Georgia Aquarium, Inc., Atlanta, Georgia, United States of America.
6
Blood Systems Research Institute, San Francisco, California, United States of America.
7
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America.
8
School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
9
Structural Biology Research Unit, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa.
10
Department of Plant Pathology and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.

Abstract

Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billion years. Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages. The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae.

PMID:
27093155
PMCID:
PMC4836724
DOI:
10.1371/journal.ppat.1005574
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center