Format

Send to

Choose Destination
Ulus Travma Acil Cerrahi Derg. 2020 Mar;26(2):153-162. doi: 10.14744/tjtes.2019.32754.

Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study.

Author information

1
Department of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon-Turkey.
2
Department of Physiology, University of Health Science Faculty of Medicine, İstanbul-Turkey.
3
Department of Nutrition and Dietetics, Karadeniz Technical University Faculty of of Health Sciences, Trabzon-Turkey.
4
Department of Histology, Karadeniz Technical University Faculty of Medicine, Trabzon-Turkey.
5
Department of General Surgery, Karadeniz Technical University Faculty of Medicine, Trabzon-Turkey.
6
Department of Medical Laboratory Techniques, Karadeniz Technical University Faculty of of Health Sciences, Trabzon-Turkey.
7
Department of Emergency Medicine, Acıbadem University Faculty of Medicine, İstanbul-Turkey.
8
Department of General Surgery, Acıbadem University Faculty of Medicine, İstanbul-Turkey.

Abstract

BACKGROUND:

To determine the value of ischemia-modified albumin (IMA) and IMA/albumin ratio (IMAR) in the diagnosis and staging of hemorrhagic shock (HS).

METHODS:

A pressure-targeted HS model was established in this study. The control and shock groups were monitored for 30 min and 60 min to simulate varying durations of exposure to HS. All subjects underwent invasive arterial monitoring during the experiment and were further divided into mild and severe shock groups based on decreases in mean arterial pressure (MAP). Biochemical and histologic comparisons were performed between the groups.

RESULTS:

Our results revealed higher IMA, IMAR, lactate, total oxidant status (TOS) and oxidative stress index (OSI) levels in both the 30- and 60-min shock groups compared to the control group. Concerning MAP-based shock staging, IMA, IMAR, lactate, TOS and OSI levels in the 30-min and 60-min mild and severe shock groups were higher than those of the controls. However, there was no significant difference between the mild and severe shock groups. A significant correlation was determined between all the biomarkers evaluated and HS-induced damage in various organs. This correlation was highest in lactate and IMAR levels.

CONCLUSION:

IMA and IMAR levels may be used in the early diagnosis of HS and also have the potential for use in determining the severity of HS. IMA and IMAR measurement may also be considered as an alternative or in addition to lactate measurement in the diagnosis of HS.

PMID:
32185760
DOI:
10.14744/tjtes.2019.32754
Free full text

Supplemental Content

Full text links

Icon for LookUs Bilisim
Loading ...
Support Center