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North Clin Istanb. 2019 Oct 24;6(4):341-347. doi: 10.14744/nci.2019.95676. eCollection 2019.

An investigation of serum irisin levels and inflammatory markers in fibromyalgia syndrome.

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Department of Physical Medicine and Rehabilitation, University of Duzce Faculty of Medicine, Duzce, Turkey.
Department of Biostatistics and Medical Informatics, University of Istanbul Medeniyet Faculty of Medicine, Istanbul, Turkey.
Department of Biochemistry, University of Duzce Faculty of Medicine, Duzce, Turkey.



In the present study, we aimed to compare serum irisin levels in patients with fibromyalgia syndrome (FMS) and healthy control subjects and also investigate the relationship between irisin, disease activity and inflammation markers in patients.


A total of 84 women, including 48 patients who were diagnosed with FMS and 36 healthy controls, were included in this study. The demographic characteristics of the patients and control group were recorded. VAS for pain and the Fibromyalgia Impact Questionnaire for the assessment of the physical function of the patients, SF36 was used for quality of life, and accompanying Beck Depression Inventory to assess depression was used. Blood samples were taken for analysis that irisin, and inflammatory markers of the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), high-sensitivity C-reactive protein (hs-CRP) and neutrophil/lymphocyte ratio (NLO). Serum irisin levels were determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method.


Serum irisin level of the patients with FMS had no significant differences compared with the healthy control group. When we compared the values of ESR, CRP, hsCRP, NLO with FMS patients and healthy controls, there was no significant difference found between them (p>0.05). There was no significant correlation between inflammatory markers and level of serum irisin (p>0.05). In patients, there was no significant correlation between inflammatory markers and level of serum irisin (p>0.05).


Irisin, which is a myokine, was determined to have no significant role in the pathogenesis of FMS. Irisin had no association with disease activity and inflammatory markers. Also, the inflammation hypothesis was not supported, which suggested in FMS.


Disease activity; fibromyalgia syndrome; inflammation; irisin

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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