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North Clin Istanb. 2018 Aug 8;6(3):315-316. doi: 10.14744/nci.2018.36539. eCollection 2019.

Lansoprazole as an uncommon cause of anaphylaxis: What to give next?

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Department of Emergency Medicine, Acibadem Hospital, Istanbul, Turkey.
Department of Emergency Medicine, Gulhane Training and Research Hospital, Ankara, Turkey.
Department of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
Department of Internal Medicine, Koc University Hospital, Istanbul, Turkey.


Proton pump inhibitors (PPIs) are one of the most prescribed drugs worldwide. Anaphylactic reactions of PPIs are rare; however, several cases have been reported. Here, we report a rare case of anaphylaxis that occurred immediately following lansoprazole intake. Following the successful management in the emergency department, skin prick and oral controlled challenge tests were performed to evaluate cross-reactivity. Thereafter, lansoprazole was switched to pantoprazole, which was well tolerated. Skin prick and oral controlled challenge tests can be performed for determining the cross-reactivity of PPIs to prevent adverse reactions.


Anaphylaxis; cross-reactivity; lansoprazole; proton pump inhibitors

Conflict of interest statement

Conflict of Interest: We do not have conflict of interest.

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