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North Clin Istanb. 2018 Aug 8;6(3):254-259. doi: 10.14744/nci.2018.58219. eCollection 2019.

Nephrolithiasis in ankylosing spondylitis and its relationship with disease assessment scales.

Author information

1
Department of Physical Medicine and Rehabilitation, Bezmialem Vakif University, Istanbul, Turkey.
2
Department of Physical Medicine and Rehabilitation, Health Science University Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
3
Department of Physical Medicine and Rehabilitation, Trakya University Faculty of Medicine, Edirne, Turkey.
4
Department of Physical Medicine and Rehabilitation, Acibadem University Faculty of Medicine, Istanbul, Turkey.
5
Department of Physical Medicine and Rehabilitation, Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey.
6
Department of Physical Medicine and Rehabilitation, Kocaeli University Faculty of Medicine, Izmit, Turkey.
7
Department of Physical Medicine and Rehabilitation, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
8
Department of Physical Medicine and Rehabilitation, Uludag University Faculty of Medicine, Bursa, Turkey.
9
Department of Physical Medicine and Rehabilitation, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
10
Department of Biostatistics, Trakya University Faculty of Medicine, Edirne, Turkey.

Abstract

OBJECTIVE:

The aim of this study was to investigate the frequency of renal calculi in patients with ankylosing spondylitis (AS) and to determine its relationship with disease assessment variables.

METHODS:

The study was designed retrospectively, and it included a cohort of 320 patients with AS diagnosed using the Modified New York Criteria. A total of 119 patients who underwent renal ultrasonography (USG), in who the erythrocyte sedimentation rate, C-reactive protein, blood calcium, phosphorus, Vitamin D, parathormone, and urinary calcium excretion were measured, and who also had lateral cervical and lumbar radiography in the same time period were extracted from the cohort. All patients' demographic characteristics and the results of blood and urine tests were recorded. The Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Mobility Index (BASMI), and Modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) were evaluated in all patients.

RESULTS:

Thirteen of the 119 patients had renal calculi confirmed by USG data. The frequency of nephrolithiasis detected by USG was 10.9% in patients with AS. The disease lasted significantly longer in patients with renal calculi ([nephrolithiasis (+): 18.39±8.72 years; nephrolithiasis (-): 12.02±8.43 years, p=0.01]). The BASMI total score was significantly higher in the group of patients with renal calculi. There was not any significant difference in terms of blood samples, HLA-B27, BASDAI, BASFI, and mSASSS between groups.

CONCLUSION:

The frequency of renal stones is increased in patients with AS compared to healthy population. Especially patients who had AS for a long time and higher BASMI values are more susceptible to renal calculi. It is important to point out that the results of this type of studies would be more reliable if the study is conducted on large patient groups and population-based prevalence.

KEYWORDS:

Ankylosing spondylitis; BASDAI; BASFI; BASMI; mSASSS; nephroilitasiz; urolithiasis

Conflict of interest statement

Conflict of Interest: The authors declare no conflict of interest.

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