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Ulus Travma Acil Cerrahi Derg. 2019 Jul;25(4):343-349. doi: 10.5505/tjtes.2018.77246.

Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats.

Author information

1
Department of Oral and Maxillofacial Surgery, Ondokuz Mayis University Faculty of Dentistry, Samsun-Turkey.
2
Department of Histology and Embryology, Ondokuz Mayis University Faculty of Veterinary, Samsun-Turkey.

Abstract

BACKGROUND:

The present study investigated the therapeutic effect of resveratrol on cardiac injury resulting from blunt chest trauma and the utility of endocan as a biomarker of the inflammation process using rats.

METHODS:

The rats were randomly divided into the following four groups (n=7 in each group): a control group (no treatment or trauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg administered via the intraperitoneal [i.p.] route group); and resveratrol + trauma group (resveratrol 0.3 mg/kg administered via the i.p. route 1 hour prior to the induction of trauma).

RESULTS:

The immunoreactivity of tumor necrosis factor-α and inducible nitric oxide synthase in the trauma group was increased, whereas the reaction intensity in resveratrol + trauma group was deceased. The mean endocan values of the differed between the groups (p<0.001). The mean endocan value in the resveratrol + trauma group was higher than that of the other groups.

CONCLUSION:

Resveratrol exhibited anti-inflammatory and antioxidant effects in lung injury after blunt chest trauma and contributed favorably to the treatment process. We believe that there is a need for further studies on the clinical use of endocan as a biomarker of inflammation in cardiac injury after blunt chest trauma.

PMID:
31297782
DOI:
10.5505/tjtes.2018.77246
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