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Ulus Travma Acil Cerrahi Derg. 2019 Jul;25(4):350-354. doi: 10.5505/tjtes.2018.14894.

Role of angiotensin-converting enzyme as prognostic marker in thoracic trauma: A prospective observational study.

Author information

1
Department of Surgery, King George's Medical University, Lucknow-India.
2
Department of Biochemistry, King George's Medical University, Lucknow-India.

Abstract

BACKGROUND:

Chest injuries, accounting for 25% of all trauma-related deaths, are one of the main causes of death in young adults. Our priority is the early identification of life-threatening injuries both immediate and delayed. The role of various biomarkers, such as Clara cell protein 16, von Willebrand factor, interleukin-6, tumor necrosis factor, and angiopoietin, has been studied in trauma-related acute respiratory distress syndrome (ARDS). Serum angiotensin-converting enzyme (ACE) levels have been studied in non-trauma-related ARDS. The aim of this prospective observational study was to evaluate the role of ACE levels as a prognostic marker in thoracic trauma.

METHODS:

A prospective observational study was conducted to evaluate serum ACE levels in thoracic trauma patients and to explore its prognostic potential with regard to clinical outcome. A total of 48 thoracic trauma patients were included in the study.

RESULTS:

The mean ACE level in the study population was 66.54+-11.18. A strong positive correlation was found among serum ACE levels and Thoracic Trauma Severity Score (TTSS).

CONCLUSION:

Our study demonstrates that serum ACE levels are increased in thoracic trauma patients with higher levels, indicating the severe nature of trauma in concordance with increased TTSS scores.

PMID:
31297773
DOI:
10.5505/tjtes.2018.14894
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