Format

Send to

Choose Destination
Ulus Travma Acil Cerrahi Derg. 2019 Jan;25(1):7-11. doi: 10.5505/tjtes.2018.83616.

Effect of curcumin on lung injury induced by skeletal muscle ischemia/reperfusion in rats.

Author information

1
Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran-Iran. dr_ashrafzadeh@yahoo.com.

Abstract

BACKGROUND:

The aim of the present study was to investigate the effects of curcumin on lung damage following ischemia/reperfusion (I/R) injury after hind limb ligation.

METHODS:

Forty Wistar rats were divided into four groups: sham (G1), I/R (G2), curcumin plus sham (G3), and curcumin plus I/R (G4). Curcumin was administered (200 mg/kg) daily for 2 weeks before the study. I/R was induced by placement of rubber tourniquets at the greater trochanters for 2 h, followed by reperfusion for 4 h.

RESULTS:

Curcumin pretreatment had significantly lower level of malondialdehydes and higher level of superoxide dismutase in the lung tissues (p<0.05) than the I/R group. Glutathione peroxidase activity was not significantly different among the groups (p>0.05). I/R caused severe histopathological injury (p<0.05), including inflammatory cell infiltration and intra-alveolar hemorrhage.

CONCLUSION:

These results suggest that curcumin pretreatment has protective effects against lung injury induced by muscle I/R.

PMID:
30742297
DOI:
10.5505/tjtes.2018.83616
Free full text

Supplemental Content

Full text links

Icon for LookUs Bilisim
Loading ...
Support Center