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Turk Kardiyol Dern Ars. 2016 Jan;44(1):53-64. doi: 10.5543/tkda.2015.47041.

Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study).

Author information

1
Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey. lalet@hacettepe.edu.tr.
2
Department of Cardiology, İnonü University Faculty of Medicine, Malatya, Turkey.
3
Department of Cardiology, Diyarbakır Training and Research Hospital, Diyarbakır, Turkey.
4
Department of Cardiology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey.
5
Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
6
Department of Cardiology, Kahramanmaraş Pazarcık Private Middle East Health Center, Kahramanmaraş, Turkey.
7
Department of Endocrinology and Metabolism, Erciyes University Faculty of Medicine, Kayseri, Turkey.
8
Department of Endocrinology and Metabolism, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
9
Department of Cardiology, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
10
Department of Cardiology, Bağcılar Training and Research Hospital, İstanbul, Turkey.
11
Department of Cardiology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey.
12
Department of Cardiology, Akademi Hospital, İstanbul, Turkey.
13
Department of Cardiology, Turkish High Specialty Training and Research Hospital, Ankara, Turkey.
14
Department of Cardiology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.
15
Department of Cardiology, Ataşehir Memorial Hospital, İstanbul, Turkey.

Abstract

OBJECTIVE:

The purpose of this study was to identify patient characteristics and statin discontinuation-related factors in patients with hypercholesterolemia.

METHODS:

A total of 532 patients (age mean±SD: 57.4±11.5 years; 52.4% women, 47.6% men) with hypercholesterolemia and statin discontinuation were included in this national cross-sectional non-interventional observational study. Data on socio-demographic characteristics of patients, cardiovascular risk factors, past treatment with and discontinuation of statin treatment were collected in one visit.

RESULTS:

Mean±SD duration of hypercholesterolemia was 4.9±4.2 years at time of discontinuation of statin treatment. Statin treatment was initiated by cardiologists in the majority of cases (55.8%), whereas discontinuation of statin treatment was decided by patients in the majority of cases (73.7%), with patients with higher (at least secondary education, 80.4%) more likely than those with lower (only primary education, 69.7%) to decide to discontinue treatment (p=0.022). Negative information about statin treatment disseminated by TV programs-mostly regarding coverage of hepatic (38.0%), renal (33.8%), and muscular (32.9%) side effects (32.9%)-was the most common reason for treatment discontinuation.

CONCLUSION:

The decision to discontinue statin treatment was made at the patient's discretion in 74% of cases, with higher likelihood of patients with higher educational status deciding to discontinue treatment and switch to non-drug lipid-lowering alternatives. Cardiologists were the physicians most frequently responsible for the initiation of the statin treatment; coverage of several non-life-threatening statin side effects by TV programs and patients' lack of information regarding high cholesterol and related risks were the leading factors predisposing to treatment discontinuation.

PMID:
26875131
[Indexed for MEDLINE]
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