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Items: 1 to 20 of 1987

1.

Azithromycin-Induced Changes to Bacterial Membrane Properties Monitored in Vitro by Second-Harmonic Light Scattering.

Gh MS, Wilhelm MJ, Dai HL.

ACS Med Chem Lett. 2018 Mar 9;9(6):569-574. doi: 10.1021/acsmedchemlett.7b00499. eCollection 2018 Jun 14.

PMID:
29937984
2.

Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.

Suciu RM, Cognetta AB 3rd, Potter ZE, Cravatt BF.

ACS Med Chem Lett. 2018 May 26;9(6):563-568. doi: 10.1021/acsmedchemlett.8b00191. eCollection 2018 Jun 14.

3.

Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor.

Wijeratne A, Xiao J, Reutter C, Furness KW, Leon R, Zia-Ebrahimi M, Cavitt RN, Strelow JM, Van Horn RD, Peng SB, Barda DA, Engler TA, Chalmers MJ.

ACS Med Chem Lett. 2018 May 21;9(6):557-562. doi: 10.1021/acsmedchemlett.8b00110. eCollection 2018 Jun 14.

PMID:
29937982
4.

Riluzole-Triazole Hybrids as Novel Chemical Probes for Neuroprotection in Amyotrophic Lateral Sclerosis.

Sweeney JB, Rattray M, Pugh V, Powell LA.

ACS Med Chem Lett. 2018 May 30;9(6):552-556. doi: 10.1021/acsmedchemlett.8b00103. eCollection 2018 Jun 14.

PMID:
29937981
5.

Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.

Dart ML, Machleidt T, Jost E, Schwinn MK, Robers MB, Shi C, Kirkland TA, Killoran MP, Wilkinson JM, Hartnett JR, Zimmerman K, Wood KV.

ACS Med Chem Lett. 2018 Apr 16;9(6):546-551. doi: 10.1021/acsmedchemlett.8b00081. eCollection 2018 Jun 14.

6.

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.

Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS.

ACS Med Chem Lett. 2018 Mar 18;9(6):540-545. doi: 10.1021/acsmedchemlett.8b00011. eCollection 2018 Jun 14.

PMID:
29937979
7.

Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.

Fröhlich T, Reiter C, Saeed MEM, Hutterer C, Hahn F, Leidenberger M, Friedrich O, Kappes B, Marschall M, Efferth T, Tsogoeva SB.

ACS Med Chem Lett. 2017 Dec 21;9(6):534-539. doi: 10.1021/acsmedchemlett.7b00412. eCollection 2018 Jun 14.

PMID:
29937978
8.

Strategy for Extending Half-life in Drug Design and Its Significance.

Gunaydin H, Altman MD, Ellis JM, Fuller P, Johnson SA, Lahue B, Lapointe B.

ACS Med Chem Lett. 2018 Apr 2;9(6):528-533. doi: 10.1021/acsmedchemlett.8b00018. eCollection 2018 Jun 14.

PMID:
29937977
9.

Why Decreasing Lipophilicity Alone Is Often Not a Reliable Strategy for Extending IV Half-life.

Broccatelli F, Aliagas I, Zheng H.

ACS Med Chem Lett. 2018 Apr 19;9(6):522-527. doi: 10.1021/acsmedchemlett.8b00047. eCollection 2018 Jun 14.

PMID:
29937976
10.

Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction.

Lorenz DA, Kaur T, Kerk SA, Gallagher EE, Sandoval J, Garner AL.

ACS Med Chem Lett. 2018 May 16;9(6):517-521. doi: 10.1021/acsmedchemlett.8b00126. eCollection 2018 Jun 14.

11.

Current Innovations in Medicinal Chemistry and Chemical Biology.

Djuric SW, Vasudevan A.

ACS Med Chem Lett. 2018 Jun 14;9(6):513-514. doi: 10.1021/acsmedchemlett.8b00252. eCollection 2018 Jun 14. No abstract available.

PMID:
29937974
12.

Correction to "Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure".

Deshmukh MS, Jain N.

ACS Med Chem Lett. 2018 Apr 19;9(5):512. doi: 10.1021/acsmedchemlett.8b00164. eCollection 2018 May 10.

13.

Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction.

Chen X, Liu L, Chen Y, Yang Y, Yang CY, Guo T, Lei M, Sun H, Wang S.

ACS Med Chem Lett. 2018 Apr 25;9(5):507-511. doi: 10.1021/acsmedchemlett.8b00152. eCollection 2018 May 10.

PMID:
29795768
14.

Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents.

Guo Y, Wang Y, Li H, Wang K, Wan Q, Li J, Zhou Y, Chen Y.

ACS Med Chem Lett. 2018 Apr 20;9(5):502-506. doi: 10.1021/acsmedchemlett.8b00125. eCollection 2018 May 10.

PMID:
29795767
15.

Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

De Prins A, Martin C, Van Wanseele Y, Tömböly C, Tourwé D, Caveliers V, Holst B, Van Eeckhaut A, Rosenkilde MM, Smolders I, Ballet S.

ACS Med Chem Lett. 2018 Apr 23;9(5):496-501. doi: 10.1021/acsmedchemlett.8b00105. eCollection 2018 May 10.

PMID:
29795766
16.

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.

Vulpetti A, Ostermann N, Randl S, Yoon T, Mac Sweeney A, Cumin F, Lorthiois E, Rüdisser S, Erbel P, Maibaum J.

ACS Med Chem Lett. 2018 Apr 24;9(5):490-495. doi: 10.1021/acsmedchemlett.8b00104. eCollection 2018 May 10.

PMID:
29795765
17.

Discovery and Development of 8-Substituted Cycloberberine Derivatives as Novel Antibacterial Agents against MRSA.

Fan T, Hu X, Tang S, Liu X, Wang Y, Deng H, You X, Jiang J, Li Y, Song D.

ACS Med Chem Lett. 2018 Apr 16;9(5):484-489. doi: 10.1021/acsmedchemlett.8b00094. eCollection 2018 May 10.

PMID:
29795764
18.

Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology.

Kaide S, Ono M, Watanabe H, Kitada A, Yoshimura M, Shimizu Y, Ihara M, Saji H.

ACS Med Chem Lett. 2018 Apr 10;9(5):478-483. doi: 10.1021/acsmedchemlett.8b00092. eCollection 2018 May 10.

PMID:
29795763
19.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

Marcin LR, Warrier J, Thangathirupathy S, Shi J, Karageorge GN, Pearce BC, Ng A, Park H, Kempson J, Li J, Zhang H, Mathur A, Reddy AB, Nagaraju G, Tonukunuru G, Gupta GVRKM, Kamble M, Mannoori R, Cheruku S, Jogi S, Gulia J, Bastia T, Sanmathi C, Aher J, Kallem R, Srikumar BN, Vijaya KK, Naidu PS, Paschapur M, Kalidindi N, Vikramadithyan R, Ramarao M, Denton R, Molski T, Shields E, Subramanian M, Zhuo X, Nophsker M, Simmermacher J, Sinz M, Albright C, Bristow LJ, Islam I, Bronson JJ, Olson RE, King D, Thompson LA, Macor JE.

ACS Med Chem Lett. 2018 Apr 13;9(5):472-477. doi: 10.1021/acsmedchemlett.8b00080. eCollection 2018 May 10.

PMID:
29795762
20.

Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates To Overcome Cancer Resistance.

Fumagalli G, Giorgi G, Vágvölgyi M, Colombo E, Christodoulou MS, Collico V, Prosperi D, Dosio F, Hunyadi A, Montopoli M, Hyeraci M, Silvani A, Lesma G, Via LD, Passarella D.

ACS Med Chem Lett. 2018 Apr 17;9(5):468-471. doi: 10.1021/acsmedchemlett.8b00078. eCollection 2018 May 10.

PMID:
29795761

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