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Items: 1 to 20 of 1094

1.

Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques.

Uno Y, Shimizu M, Yoda H, Origuchi Y, Yamazaki H.

Drug Metab Pharmacokinet. 2018 Sep 7. pii: S1347-4367(18)30138-1. doi: 10.1016/j.dmpk.2018.09.001. [Epub ahead of print]

PMID:
30420260
2.

The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats.

Imaoka A, Seki K, Akiyoshi T, Ohtani H.

Drug Metab Pharmacokinet. 2018 Aug 28. pii: S1347-4367(18)30079-X. doi: 10.1016/j.dmpk.2018.08.008. [Epub ahead of print]

PMID:
30415897
3.

Regulated LC-MS/MS bioanalysis technology for therapeutic antibodies and Fc-fusion proteins using structure-indicated approach.

Iwamoto N, Shimada T.

Drug Metab Pharmacokinet. 2018 Oct 19. pii: S1347-4367(18)30139-3. doi: 10.1016/j.dmpk.2018.10.002. [Epub ahead of print] Review.

PMID:
30392772
4.

A spatial-temporal model for zonal hepatotoxicity of acetaminophen.

Means SA, Ho H.

Drug Metab Pharmacokinet. 2018 Oct 8. pii: S1347-4367(18)30043-0. doi: 10.1016/j.dmpk.2018.09.266. [Epub ahead of print]

PMID:
30377056
5.

Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation.

Saito T, Gutiérrez Rico EM, Kikuchi A, Kaneko A, Kumondai M, Akai F, Saigusa D, Oda A, Hirasawa N, Hiratsuka M.

Drug Metab Pharmacokinet. 2018 Aug 25. pii: S1347-4367(18)30073-9. doi: 10.1016/j.dmpk.2018.08.004. [Epub ahead of print]

PMID:
30366777
6.

Gap between the US and Japan in coverage of pharmacogenomic biomarkers by health insurance programs: More coverage is needed in Japan.

Hikino K, Fukunaga K, Mushiroda T.

Drug Metab Pharmacokinet. 2018 Sep 1. pii: S1347-4367(18)30050-8. doi: 10.1016/j.dmpk.2018.08.006. [Epub ahead of print]

PMID:
30360950
7.

Characterization of changes in HbA1c in patients with and without secondary failure after metformin treatments by a population pharmacodynamic analysis using mixture models.

Tamaki Y, Maema K, Kakara M, Fukae M, Kinoshita R, Kashihara Y, Muraki S, Hirota T, Ieiri I.

Drug Metab Pharmacokinet. 2018 Aug 16. pii: S1347-4367(17)30232-X. doi: 10.1016/j.dmpk.2018.08.002. [Epub ahead of print]

PMID:
30360949
8.

Valproic acid transport in the choriocarcinoma placenta cell line JEG-3 proceeds independently of the proton-dependent transporters MCT1 and MCT4.

Ishiguro Y, Furugen A, Narumi K, Nishimura A, Hirano T, Kobayashi M, Iseki K.

Drug Metab Pharmacokinet. 2018 Apr 5. pii: S1347-4367(17)30550-5. doi: 10.1016/j.dmpk.2018.03.004. [Epub ahead of print]

PMID:
30341000
9.

ABCG2 rs2231142 (Q141K) and oxypurinol concentrations in people with gout receiving allopurinol.

Stamp LK, Wallace M, Roberts RL, Frampton C, Miner JN, Merriman TR, Dalbeth N.

Drug Metab Pharmacokinet. 2018 Sep 18. pii: S1347-4367(18)30109-5. doi: 10.1016/j.dmpk.2018.09.002. [Epub ahead of print] No abstract available.

PMID:
30274827
10.

Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS).

Kumondai M, Ito A, Hishinuma E, Kikuchi A, Saito T, Takahashi M, Tsukada C, Saito S, Yasuda J, Nagasaki M, Minegishi N, Yamamoto M, Kaneko A, Teramoto I, Kimura M, Hirasawa N, Hiratsuka M.

Drug Metab Pharmacokinet. 2018 Aug 22. pii: S1347-4367(18)30064-8. doi: 10.1016/j.dmpk.2018.08.003. [Epub ahead of print]

PMID:
30269962
11.

Uptake and metabolism of mizoribine, an immunosuppressant, in L5178Y-R mouse lymphoma cells in vitro and peripheral blood mononuclear cells of rats and kidney transplant recipients in vivo.

Oda K, Mori N, Okumi M, Furusawa M, Ishiguro M, Inoue K, Shuto S, Unagami K, Ishida H, Tanabe K, Murakami T.

Drug Metab Pharmacokinet. 2018 Oct;33(5):232-239. doi: 10.1016/j.dmpk.2018.08.007. Epub 2018 Aug 25.

PMID:
30241694
12.

Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants.

Siu YA, Hao MH, Dixit V, Lai WG.

Drug Metab Pharmacokinet. 2018 Oct;33(5):219-227. doi: 10.1016/j.dmpk.2018.06.001. Epub 2018 Jun 19.

PMID:
30219715
13.

HLA-B*58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population.

Dou Y, Peng P, Cai C, Ye A, Kong L, Zhang R.

Drug Metab Pharmacokinet. 2018 Oct;33(5):228-231. doi: 10.1016/j.dmpk.2018.08.001. Epub 2018 Aug 14.

14.

Genetic variations in the monocarboxylate transporter genes (SLC16A1, SLC16A3, and SLC16A11) in the Japanese population.

Kimura Y, Kobayashi M, Asari M, Higuchi I, Narumi K, Furugen A, Iseki K.

Drug Metab Pharmacokinet. 2018 Oct;33(5):215-218. doi: 10.1016/j.dmpk.2018.05.001. Epub 2018 Jun 1.

PMID:
30177396
15.

miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms.

Tatsumi N, Tokumitsu S, Nakano M, Fukami T, Nakajima M.

Drug Metab Pharmacokinet. 2018 Aug;33(4):203-210. doi: 10.1016/j.dmpk.2018.05.002. Epub 2018 May 16.

PMID:
30001838
16.

Bisphenol A induces Nrf2-dependent drug-metabolizing enzymes through nitrosylation of Keap1.

Nakamura M, Yamanaka H, Oguro A, Imaoka S.

Drug Metab Pharmacokinet. 2018 Aug;33(4):194-202. doi: 10.1016/j.dmpk.2018.04.003. Epub 2018 Apr 22.

PMID:
29960846
17.

The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.

Terashima J, Jimma Y, Jimma K, Hakata S, Yachi M, Habano W, Ozawa S.

Drug Metab Pharmacokinet. 2018 Aug;33(4):211-214. doi: 10.1016/j.dmpk.2018.04.002. Epub 2018 Apr 24.

PMID:
29921510
18.

Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach.

Chan CYS, Roberts O, Rajoli RKR, Liptrott NJ, Siccardi M, Almond L, Owen A.

Drug Metab Pharmacokinet. 2018 Aug;33(4):179-187. doi: 10.1016/j.dmpk.2018.01.004. Epub 2018 Mar 16.

19.

An analysis on distribution and inter-relationships of biomarkers under rivaroxaban in Japanese patients with non-valvular atrial fibrillation (CVI ARO 1).

Suzuki S, Yamashita T, Kasai H, Otsuka T, Sagara K.

Drug Metab Pharmacokinet. 2018 Aug;33(4):188-193. doi: 10.1016/j.dmpk.2018.02.002. Epub 2018 Mar 15.

PMID:
29773500
20.

Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes.

Lee E, Kim JH, Shon JC, Wu Z, Kim HJ, Gim M, Lee T, Liu KH.

Drug Metab Pharmacokinet. 2018 Jun;33(3):159-163. doi: 10.1016/j.dmpk.2018.02.001. Epub 2018 Mar 15.

PMID:
29759885

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