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Items: 1 to 20 of 1086

1.

ABCG2 rs2231142 (Q141K) and oxypurinol concentrations in people with gout receiving allopurinol.

Stamp LK, Wallace M, Roberts RL, Frampton C, Miner JN, Merriman TR, Dalbeth N.

Drug Metab Pharmacokinet. 2018 Sep 18. pii: S1347-4367(18)30109-5. doi: 10.1016/j.dmpk.2018.09.002. [Epub ahead of print] No abstract available.

PMID:
30274827
2.

Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS).

Kumondai M, Ito A, Hishinuma E, Kikuchi A, Saito T, Takahashi M, Tsukada C, Saito S, Yasuda J, Nagasaki M, Minegishi N, Yamamoto M, Kaneko A, Teramoto I, Kimura M, Hirasawa N, Hiratsuka M.

Drug Metab Pharmacokinet. 2018 Aug 22. pii: S1347-4367(18)30064-8. doi: 10.1016/j.dmpk.2018.08.003. [Epub ahead of print]

PMID:
30269962
3.

Uptake and metabolism of mizoribine, an immunosuppressant, in L5178Y-R mouse lymphoma cells in vitro and peripheral blood mononuclear cells of rats and kidney transplant recipients in vivo.

Oda K, Mori N, Okumi M, Furusawa M, Ishiguro M, Inoue K, Shuto S, Unagami K, Ishida H, Tanabe K, Murakami T.

Drug Metab Pharmacokinet. 2018 Oct;33(5):232-239. doi: 10.1016/j.dmpk.2018.08.007. Epub 2018 Aug 25.

PMID:
30241694
4.

Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants.

Siu YA, Hao MH, Dixit V, Lai WG.

Drug Metab Pharmacokinet. 2018 Oct;33(5):219-227. doi: 10.1016/j.dmpk.2018.06.001. Epub 2018 Jun 19.

PMID:
30219715
5.

HLA-B*58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population.

Dou Y, Peng P, Cai C, Ye A, Kong L, Zhang R.

Drug Metab Pharmacokinet. 2018 Oct;33(5):228-231. doi: 10.1016/j.dmpk.2018.08.001. Epub 2018 Aug 14.

PMID:
30193812
6.

Genetic variations in the monocarboxylate transporter genes (SLC16A1, SLC16A3, and SLC16A11) in the Japanese population.

Kimura Y, Kobayashi M, Asari M, Higuchi I, Narumi K, Furugen A, Iseki K.

Drug Metab Pharmacokinet. 2018 Oct;33(5):215-218. doi: 10.1016/j.dmpk.2018.05.001. Epub 2018 Jun 1.

PMID:
30177396
7.

miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms.

Tatsumi N, Tokumitsu S, Nakano M, Fukami T, Nakajima M.

Drug Metab Pharmacokinet. 2018 Aug;33(4):203-210. doi: 10.1016/j.dmpk.2018.05.002. Epub 2018 May 16.

PMID:
30001838
8.

Bisphenol A induces Nrf2-dependent drug-metabolizing enzymes through nitrosylation of Keap1.

Nakamura M, Yamanaka H, Oguro A, Imaoka S.

Drug Metab Pharmacokinet. 2018 Aug;33(4):194-202. doi: 10.1016/j.dmpk.2018.04.003. Epub 2018 Apr 22.

PMID:
29960846
9.

The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.

Terashima J, Jimma Y, Jimma K, Hakata S, Yachi M, Habano W, Ozawa S.

Drug Metab Pharmacokinet. 2018 Aug;33(4):211-214. doi: 10.1016/j.dmpk.2018.04.002. Epub 2018 Apr 24.

PMID:
29921510
10.

Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach.

Chan CYS, Roberts O, Rajoli RKR, Liptrott NJ, Siccardi M, Almond L, Owen A.

Drug Metab Pharmacokinet. 2018 Aug;33(4):179-187. doi: 10.1016/j.dmpk.2018.01.004. Epub 2018 Mar 16.

11.

An analysis on distribution and inter-relationships of biomarkers under rivaroxaban in Japanese patients with non-valvular atrial fibrillation (CVI ARO 1).

Suzuki S, Yamashita T, Kasai H, Otsuka T, Sagara K.

Drug Metab Pharmacokinet. 2018 Aug;33(4):188-193. doi: 10.1016/j.dmpk.2018.02.002. Epub 2018 Mar 15.

PMID:
29773500
12.

Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes.

Lee E, Kim JH, Shon JC, Wu Z, Kim HJ, Gim M, Lee T, Liu KH.

Drug Metab Pharmacokinet. 2018 Jun;33(3):159-163. doi: 10.1016/j.dmpk.2018.02.001. Epub 2018 Mar 15.

PMID:
29759885
13.

Assessment of induced CYP3A activity in pregnant women using 4β-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker.

Kim AH, Kim B, Rhee SJ, Lee Y, Park JS, Lee SM, Kim SM, Lee S, Yu KS, Jang IJ, Cho JY.

Drug Metab Pharmacokinet. 2018 Jun;33(3):173-178. doi: 10.1016/j.dmpk.2018.04.004. Epub 2018 Apr 25.

PMID:
29759884
14.

Total hepatocellular disposition profiling of rosuvastatin and pitavastatin in sandwich-cultured human hepatocytes.

Kanda K, Takahashi R, Yoshikado T, Sugiyama Y.

Drug Metab Pharmacokinet. 2018 Jun;33(3):164-172. doi: 10.1016/j.dmpk.2018.04.001. Epub 2018 Apr 9.

15.

Points-to-consider documents: Scientific information on the evaluation of genetic polymorphisms during non-clinical studies and phase I clinical trials in the Japanese population.

Hiratsuka M, Hirasawa N, Oshima Y, Kodama S, Miyata T, Dan T, Takatoku H, Kuribayashi H, Nakamura R, Saito Y.

Drug Metab Pharmacokinet. 2018 Jun;33(3):141-149. doi: 10.1016/j.dmpk.2018.01.005. Epub 2018 Mar 15. Review.

PMID:
29703433
16.

Importance of cynomolgus monkeys in development of monoclonal antibody drugs.

Iwasaki K, Uno Y, Utoh M, Yamazaki H.

Drug Metab Pharmacokinet. 2018 Mar 20. pii: S1347-4367(17)30074-5. doi: 10.1016/j.dmpk.2018.02.003. [Epub ahead of print] Review.

PMID:
29655914
17.

A randomized, placebo-controlled, single ascending-dose study to assess the safety, tolerability, pharmacokinetics, and immunogenicity of subcutaneous tralokinumab in Japanese healthy volunteers.

Baverel P, She D, Piper E, Ueda S, Yoshioka T, Faggioni R, Gevorkyan H.

Drug Metab Pharmacokinet. 2018 Jun;33(3):150-158. doi: 10.1016/j.dmpk.2017.12.001. Epub 2017 Dec 12.

18.

Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes.

Shi J, Wang X, Lyu L, Jiang H, Zhu HJ.

Drug Metab Pharmacokinet. 2018 Apr;33(2):133-140. doi: 10.1016/j.dmpk.2018.03.003. Epub 2018 Mar 10.

PMID:
29610054
19.

Collaborative study using common samples to evaluate the performance of anti-drug antibody assays constructed by different companies.

Niimi S, Nishimiya K, Nishidate M, Saito T, Minoura K, Kadotsuji K, Shimakura J, Shigemizu H, Hosogi J, Adachi M, Hashimoto T, Mori T, Harada H, Yamamoto KI, Nakamura T, Nomura T, Yamaguchi I, Sonehara K, Ishii-Watabe A, Kawasaki N.

Drug Metab Pharmacokinet. 2018 Apr;33(2):125-132. doi: 10.1016/j.dmpk.2018.03.002. Epub 2018 Mar 8.

PMID:
29610053
20.

A phase I, open-label, single-dose micro tracer mass balance study of 14C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry.

Miyatake D, Nakada N, Takada A, Kato K, Taniuchi Y, Katashima M, Sawamoto T.

Drug Metab Pharmacokinet. 2018 Apr;33(2):118-124. doi: 10.1016/j.dmpk.2018.03.001. Epub 2018 Mar 7.

PMID:
29606543

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