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Items: 1 to 20 of 8534

1.

Metabolism of anethole dithiolethione by rat and human liver microsomes: formation of various products deriving from its O-demethylation and S-oxidation. Involvement of cytochromes P450 and flavin monooxygenases in these pathways.

Dulac M, Sassi A, Nagarathinan C, Christen MO, Dansette PM, Mansuy D, Boucher JL.

Drug Metab Dispos. 2018 Jul 17. pii: dmd.118.082545. doi: 10.1124/dmd.118.082545. [Epub ahead of print]

PMID:
30018103
2.

Cryopreserved human intestinal mucosal epithelium: a novel in vitro experimental system for the evaluation of enteric drug metabolism, P450 induction, and enterotoxicity.

Li AP, Alam N, Amaral K, Ho MD, Loretz C, Mitchell W, Yang Q.

Drug Metab Dispos. 2018 Jul 13. pii: dmd.118.082875. doi: 10.1124/dmd.118.082875. [Epub ahead of print]

PMID:
30006371
3.

Biotransformation of ilaprazole in human liver microsomes and human: role of CYP3A4 in ilaprazole clearance and drug-drug interaction.

Pu J, Wang F, Tang W, Zhu M.

Drug Metab Dispos. 2018 Jul 12. pii: dmd.118.081570. doi: 10.1124/dmd.118.081570. [Epub ahead of print]

PMID:
30002078
4.

Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis.

Wollmann BM, Syversen SW, Vistnes M, Lie E, Mehus LL, Molden E.

Drug Metab Dispos. 2018 Jul 10. pii: dmd.118.082065. doi: 10.1124/dmd.118.082065. [Epub ahead of print]

PMID:
29991576
5.

Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 vs. Neonatal Cytochrome P450 3A7.

Godamudunage MP, Grech AM, Scott EE.

Drug Metab Dispos. 2018 Jul 10. pii: dmd.118.082032. doi: 10.1124/dmd.118.082032. [Epub ahead of print]

PMID:
29991575
6.

Differences of the in vivo and in vitro metabolism of imrecoxib in humans: formation of rate-limiting aldehyde intermediate.

Hou X, Zhou J, Yu S, Zhou L, Zhang Y, Zhong D, Chen X.

Drug Metab Dispos. 2018 Jul 6. pii: dmd.118.081182. doi: 10.1124/dmd.118.081182. [Epub ahead of print]

PMID:
29980580
7.

Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction.

Liu D, Qin S, Ray B, Kalari KR, Wang L, Weinshilboum RM.

Drug Metab Dispos. 2018 Jul 6. pii: dmd.118.082164. doi: 10.1124/dmd.118.082164. [Epub ahead of print]

PMID:
29980579
8.

Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening.

Fedecostante M, Westphal K, Buono M, Sanchez Romero N, Wilmer MJ, Kerkering J, Baptista PM, Hoenderop JG, Masereeuw R.

Drug Metab Dispos. 2018 Jul 6. pii: dmd.118.080721. doi: 10.1124/dmd.118.080721. [Epub ahead of print]

PMID:
29980578
9.
10.

Glycyrrhizin alleviates non-alcoholic steatohepatitis via modulating bile acids and meta-inflammation.

Yan T, Wang H, Cao L, Wang Q, Takahashi S, Yagai T, Li G, Krausz KW, Wang G, Gonzalez FJ, Hao H.

Drug Metab Dispos. 2018 Jun 29. pii: dmd.118.082008. doi: 10.1124/dmd.118.082008. [Epub ahead of print]

PMID:
29959134
11.

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance.

Kenny JR, Ramsden D, Buckley DB, Dallas S, Fung C, Mohutsky M, Einolf HJ, Chen L, Dekeyser JG, Fitzgerald M, Goosen TC, Siu YA, Walsky RL, Zhang G, Tweedie D, Hariparsad N.

Drug Metab Dispos. 2018 Jun 29. pii: dmd.118.081927. doi: 10.1124/dmd.118.081927. [Epub ahead of print]

PMID:
29959133
12.

Content and activities of UGT2B7 in human liver in vitro and predicted in vivo: a bottom-up approach.

Xu C, Gao J, Zhang HF, Gao N, Guo YY, Fang Y, Wen Q, Qiao HL.

Drug Metab Dispos. 2018 Jun 21. pii: dmd.118.082024. doi: 10.1124/dmd.118.082024. [Epub ahead of print]

PMID:
29929994
13.

Complete substrate inhibition of cytochrome P450 2C8 by AZD9496, an oral selective estrogen receptor degrader.

Bapiro TE, Sykes A, Martin S, Davies M, Yates JW, Hoch M, Rollison HE, Jones B.

Drug Metab Dispos. 2018 Jun 19. pii: dmd.118.081539. doi: 10.1124/dmd.118.081539. [Epub ahead of print]

PMID:
29921707
14.

Decreased Kidney Function is Associated with Enhanced Hepatic Flavin Monooxygenase Activity and Increased Circulating Trimethylamine N-oxide Concentrations in Mice.

Johnson C, Prokopienko AJ, West RE 3rd, Nolin TD, Stubbs JR.

Drug Metab Dispos. 2018 Jun 18. pii: dmd.118.081646. doi: 10.1124/dmd.118.081646. [Epub ahead of print]

PMID:
29915157
15.

Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 (Oct3) in Tissue Selective Accumulation of para-hydroxymethamphetamine.

Wagner DJ, Shireman LM, Ahn S, Shen DD, Wang J.

Drug Metab Dispos. 2018 Jun 18. pii: dmd.118.082131. doi: 10.1124/dmd.118.082131. [Epub ahead of print]

PMID:
29915156
16.

An investigation into the prediction of the plasma concentration-time profile and its inter-individual variability for a range of flavin-containing monooxygenase substrates using a mechanistic physiologically based pharmacokinetic modelling approach.

Pilla Reddy V, Jones BC, Colclough N, Srivastava A, Wilson J, Li D.

Drug Metab Dispos. 2018 Jun 12. pii: dmd.118.080648. doi: 10.1124/dmd.118.080648. [Epub ahead of print]

PMID:
29895591
17.

Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Oatps.

Ishida K, Ullah M, Toth B, Juhasz V, Unadkat JD.

Drug Metab Dispos. 2018 Jun 11. pii: dmd.118.080770. doi: 10.1124/dmd.118.080770. [Epub ahead of print]

PMID:
29891589
18.

Consequences of Phenytoin Exposure on Hepatic Cytochrome P450 Expression during Postnatal Liver Maturation in Mice.

Piekos SC, Chen L, Wang P, Shi J, Yaqoob S, Zhu HJ, Ma X, Zhong XB.

Drug Metab Dispos. 2018 Aug;46(8):1241-1250. doi: 10.1124/dmd.118.080861. Epub 2018 Jun 8.

PMID:
29884652
19.

Three Faces of Mercaptopurine Cytotoxicity In Vitro: Methylation, Nucleotide Homeostasis, and Deoxythioguanosine in DNA.

Coulthard SA, McGarrity S, Sahota K, Berry P, Redfern CPF.

Drug Metab Dispos. 2018 Aug;46(8):1191-1199. doi: 10.1124/dmd.118.081844. Epub 2018 Jun 8.

PMID:
29884651
20.

Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.

Kosa RE, Lazzaro S, Bi YA, Tierney B, Gates D, Modi S, Costales C, Rodrigues AD, Tremaine LM, Varma MV.

Drug Metab Dispos. 2018 Aug;46(8):1179-1189. doi: 10.1124/dmd.118.081794. Epub 2018 Jun 7.

PMID:
29880631

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