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Items: 1 to 20 of 75

1.

Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies.

Fuchs H, Niesler N, Trautner A, Sama S, Jerz G, Panjideh H, Weng A.

Biomedicines. 2017 Mar 29;5(2). pii: E14. doi: 10.3390/biomedicines5020014. Review.

2.

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.

Gilabert-Oriol R, Furness SGB, Stringer BW, Weng A, Fuchs H, Day BW, Kourakis A, Boyd AW, Hare DL, Thakur M, Johns TG, Wookey PJ.

Cancer Immunol Immunother. 2017 Sep;66(9):1217-1228. doi: 10.1007/s00262-017-2013-z. Epub 2017 May 13.

PMID:
28501939
3.

Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin.

Gilabert-Oriol R, Thakur M, Haussmann K, Niesler N, Bhargava C, Görick C, Fuchs H, Weng A.

Planta Med. 2016 Dec;82(18):1525-1531. Epub 2016 Jul 8.

PMID:
27392242
4.

Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861.

Gilabert-Oriol R, Weng A, Trautner A, Weise C, Schmid D, Bhargava C, Niesler N, Wookey PJ, Fuchs H, Thakur M.

Biochem Pharmacol. 2015 Oct 1;97(3):247-55. doi: 10.1016/j.bcp.2015.07.040. Epub 2015 Aug 5.

PMID:
26253687
5.

Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina.

Gilabert-Oriol R, Weng A, von Mallinckrodt B, Stöshel A, Nissi L, Melzig MF, Fuchs H, Thakur M.

Int J Pharm. 2015 Jun 20;487(1-2):39-48. doi: 10.1016/j.ijpharm.2015.03.063. Epub 2015 Mar 31.

PMID:
25839418
6.

Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma.

von Mallinckrodt B, Thakur M, Weng A, Gilabert-Oriol R, Dürkop H, Brenner W, Lukas M, Beindorff N, Melzig MF, Fuchs H.

Future Oncol. 2014 Nov;10(14):2161-75. doi: 10.2217/fon.14.164.

PMID:
25471031
7.

Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent.

Holmes SE, Bachran C, Fuchs H, Weng A, Melzig MF, Flavell SU, Flavell DJ.

Immunopharmacol Immunotoxicol. 2015 Feb;37(1):42-55. doi: 10.3109/08923973.2014.971964. Epub 2014 Oct 27.

PMID:
25347443
8.

Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.

Gilabert-Oriol R, Weng A, Mallinckrodt Bv, Melzig MF, Fuchs H, Thakur M.

Curr Pharm Des. 2014;20(42):6584-643. Review.

9.

Reporter assay for endo/lysosomal escape of toxin-based therapeutics.

Gilabert-Oriol R, Thakur M, von Mallinckrodt B, Bhargava C, Wiesner B, Eichhorst J, Melzig MF, Fuchs H, Weng A.

Toxins (Basel). 2014 May 22;6(5):1644-66. doi: 10.3390/toxins6051644.

10.

High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins.

Thakur M, Jerz G, Tuwalska D, Gilabert-Oriol R, Wybraniec S, Winterhalter P, Fuchs H, Weng A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 1;955-956:1-9. doi: 10.1016/j.jchromb.2014.02.008. Epub 2014 Feb 19.

PMID:
24631804
11.

Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells.

Gilabert-Oriol R, Thakur M, von Mallinckrodt B, Hug T, Wiesner B, Eichhorst J, Melzig MF, Fuchs H, Weng A.

Mol Pharm. 2013 Nov 4;10(11):4347-57. doi: 10.1021/mp400444q. Epub 2013 Oct 7.

PMID:
24050452
12.

Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge.

Thakur M, Weng A, Pieper A, Mergel K, von Mallinckrodt B, Gilabert-Oriol R, Görick C, Wiesner B, Eichhorst J, Melzig MF, Fuchs H.

Int J Biol Macromol. 2013 Oct;61:285-94. doi: 10.1016/j.ijbiomac.2013.07.008. Epub 2013 Jul 22.

PMID:
23887142
13.

Small structural differences of targeted anti-tumor toxins result in strong variation of protein expression.

Gilabert-Oriol R, Thakur M, Weise C, Dernedde J, von Mallinckrodt B, Fuchs H, Weng A.

Protein Expr Purif. 2013 Sep;91(1):54-60. doi: 10.1016/j.pep.2013.07.004. Epub 2013 Jul 16.

PMID:
23867360
14.

Real-time analysis of membrane permeabilizing effects of oleanane saponins.

Gilabert-Oriol R, Mergel K, Thakur M, von Mallinckrodt B, Melzig MF, Fuchs H, Weng A.

Bioorg Med Chem. 2013 Apr 15;21(8):2387-2395. doi: 10.1016/j.bmc.2013.01.061. Epub 2013 Feb 8.

PMID:
23454223
15.

The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b.

Zahn C, Kaup M, Fluhrer R, Fuchs H.

FEBS J. 2013 Apr;280(7):1653-63. doi: 10.1111/febs.12176. Epub 2013 Mar 1.

16.

Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice.

Thakur M, Mergel K, Weng A, von Mallinckrodt B, Gilabert-Oriol R, Dürkop H, Melzig MF, Fuchs H.

Mol Oncol. 2013 Jun;7(3):475-83. doi: 10.1016/j.molonc.2012.12.004. Epub 2012 Dec 28.

17.

Saponins modulate the intracellular trafficking of protein toxins.

Weng A, Thakur M, von Mallinckrodt B, Beceren-Braun F, Gilabert-Oriol R, Wiesner B, Eichhorst J, Böttger S, Melzig MF, Fuchs H.

J Control Release. 2012 Nov 28;164(1):74-86. doi: 10.1016/j.jconrel.2012.10.002. Epub 2012 Oct 10.

PMID:
23063550
18.

Targeted tumor therapy with a fusion protein of an antiangiogenic human recombinant scFv and yeast cytosine deaminase.

Schellmann N, Panjideh H, Fasold P, Bachran D, Bachran C, Deckert PM, Fuchs H.

J Immunother. 2012 Sep;35(7):570-8.

PMID:
22892453
19.

Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement.

Thakur M, Mergel K, Weng A, Frech S, Gilabert-Oriol R, Bachran D, Melzig MF, Fuchs H.

Biosens Bioelectron. 2012 May 15;35(1):503-6. doi: 10.1016/j.bios.2012.03.024. Epub 2012 Mar 21.

PMID:
22498641
20.

The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins.

Weng A, Thakur M, Beceren-Braun F, Bachran D, Bachran C, Riese SB, Jenett-Siems K, Gilabert-Oriol R, Melzig MF, Fuchs H.

Mol Oncol. 2012 Jun;6(3):323-32. doi: 10.1016/j.molonc.2012.01.004. Epub 2012 Jan 24.

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