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Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

Webster CP, Smith EF, Shaw PJ, De Vos KJ.

Front Mol Neurosci. 2017 May 2;10:123. doi: 10.3389/fnmol.2017.00123. eCollection 2017. Review.


Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies.

Sarowar T, Grabrucker AM.

Neural Plast. 2016;2016:8051861. Epub 2016 Oct 4. Review.


The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.

Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ.

EMBO J. 2016 Aug 1;35(15):1656-76. doi: 10.15252/embj.201694401. Epub 2016 Jun 22.


Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.

Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Ă–zdinler PH.

Hum Mol Genet. 2016 Mar 15;25(6):1074-87. doi: 10.1093/hmg/ddv631. Epub 2016 Jan 10.


Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences.

Sundaramoorthy V, Sultana JM, Atkin JD.

Front Neurosci. 2015 Oct 27;9:400. doi: 10.3389/fnins.2015.00400. eCollection 2015. Review.


Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.

Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA.

J Biol Chem. 2015 Apr 10;290(15):9363-76. doi: 10.1074/jbc.M114.575217. Epub 2015 Feb 9.


Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration.

Stankiewicz TR, Linseman DA.

Front Cell Neurosci. 2014 Oct 7;8:314. doi: 10.3389/fncel.2014.00314. eCollection 2014. Review.


The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.

Droppelmann CA, Campos-Melo D, Volkening K, Strong MJ.

Front Cell Neurosci. 2014 Sep 10;8:282. doi: 10.3389/fncel.2014.00282. eCollection 2014. Review.


The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.

Bucci C, Alifano P, Cogli L.

Membranes (Basel). 2014 Oct 6;4(4):642-77. doi: 10.3390/membranes4040642. Review.


Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis.

D'Ambrosi N, Rossi S, Gerbino V, Cozzolino M.

Front Cell Neurosci. 2014 Sep 8;8:279. doi: 10.3389/fncel.2014.00279. eCollection 2014. Review.


C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

Farg MA, Sundaramoorthy V, Sultana JM, Yang S, Atkinson RA, Levina V, Halloran MA, Gleeson PA, Blair IP, Soo KY, King AE, Atkin JD.

Hum Mol Genet. 2014 Jul 1;23(13):3579-95. doi: 10.1093/hmg/ddu068. Epub 2014 Feb 18.


Vinculin and Rab5 complex is required [correction of requited]for uptake of Staphylococcus aureus and interleukin-6 expression.

Hagiwara M, Kokubu E, Sugiura S, Komatsu T, Tada H, Isoda R, Tanigawa N, Kato Y, Ishida N, Kobayashi K, Nakashima M, Ishihara K, Matsushita K.

PLoS One. 2014 Jan 23;9(1):e87373. doi: 10.1371/journal.pone.0087373. eCollection 2014.


Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease.

Cook DR, Rossman KL, Der CJ.

Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep 16. Review.


Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases.

Otomo A, Pan L, Hadano S.

Neurol Res Int. 2012;2012:498428. doi: 10.1155/2012/498428. Epub 2012 Jul 17.


Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity.

Li Q, Spencer NY, Pantazis NJ, Engelhardt JF.

J Biol Chem. 2011 Nov 18;286(46):40151-62. doi: 10.1074/jbc.M111.279711. Epub 2011 Sep 20.


A screen to identify cellular modulators of soluble levels of an amyotrophic lateral sclerosis (ALS)-causing mutant SOD1.

Somalinga BR, Miller GA, Malik HT, Wigley WC, Thomas PJ.

J Biomol Screen. 2011 Oct;16(9):974-85. doi: 10.1177/1087057111418505. Epub 2011 Aug 29.


Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.

Agola JO, Jim PA, Ward HH, Basuray S, Wandinger-Ness A.

Clin Genet. 2011 Oct;80(4):305-18. doi: 10.1111/j.1399-0004.2011.01724.x. Epub 2011 Jul 13. Review.


Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.

Kajiho H, Sakurai K, Minoda T, Yoshikawa M, Nakagawa S, Fukushima S, Kontani K, Katada T.

J Biol Chem. 2011 Jul 8;286(27):24364-73. doi: 10.1074/jbc.M110.172445. Epub 2011 May 17.


Rab GTPases implicated in inherited and acquired disorders.

Mitra S, Cheng KW, Mills GB.

Semin Cell Dev Biol. 2011 Feb;22(1):57-68. doi: 10.1016/j.semcdb.2010.12.005. Epub 2010 Dec 13. Review.


Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.

Liu W, Tundwal K, Liang Q, Goplen N, Rozario S, Quayum N, Gorska M, Wenzel S, Balzar S, Alam R.

Mol Cell Biol. 2010 Apr;30(7):1783-99. doi: 10.1128/MCB.01003-09. Epub 2010 Feb 1.

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